Assessment of Kupffer cells by ferumoxides-enhanced MR imaging is beneficial for diagnosis of hepatocellular carcinoma: comparison of pathological diagnosis and perfusion patterns assessed by CT hepatic arteriography and CT arterioportography

Asahina, Yasuhiro; Izumi, Namiki; Uchihara, Masakatsu; Noguchi, Osamu; Ueda, Ken; Inoue, Kazunari; Nishimura, Yuki; Tsuchiya, Kaoru; Hamano, Kenzo; Itakura, Jun; Himeno, Yoshiro; Koike, Masato; Miyake, Shozo

doi:10.1016/s1386-6346(03)00261-4

Cited by 26 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most sensitive modality capable of objectively depicting the early carcinogenesis process among currently available imaging systems is (1) CTAP, followed by (2) CTHA [239,240], (3) CEUS [241][242][243], and (4) SPIO-enhanced MRI [225,244]. Portal blood flow may be maintained in some cases of DN and early HCC but reduced in other nodules, although the pathology remains because of early HCC, in which arterial blood flow has not yet increased.…”

Section: Diagnostic Algorithm Of Hypovascular Hccmentioning

confidence: 99%

See 1 more Smart Citation

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

View full text Add to dashboard Cite

Introduction The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the management of hepatocellular carcinoma (HCC) in December 2008 to develop consensus recommendations. Methods The working party consisted of expert hepatologist, hepatobiliary surgeon, radiologist, and oncologist from Asian-Pacific region, who were requested to make drafts prior to the consensus meeting held at Bali, Indonesia on 4 December 2008. The quality of existing evidence and strength of recommendations were ranked from 1 (highest) to 5 (lowest) and from A (strongest) to D (weakest), respectively, according to the Oxford system of evidence-based approach for developing the consensus statements. 123Hepatol Int (2010) 4: 439-474 DOI 10.1007/s12072-010-9165-7 Results Participants of the consensus meeting assessed the quality of cited studies and assigned grades to the recommendation statements. Finalized recommendations were presented at the fourth APASL single topic conference on viral-related HCC at Bali, Indonesia and approved by the participants of the conference.

show abstract

Section: Diagnostic Algorithm Of Hypovascular Hccmentioning

confidence: 99%

“…Addition of the postvascular phase (Kupffer phase) allows an assumption of the degree of malignancy based on Kupffer function [189,225,244].…”

Section: Diagnostic Algorithm Of Hypovascular Hccmentioning

confidence: 99%

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Signal intensity changes in SPIO-enhanced MRI reflect a change in Kupffer cell numbers in HCCs and dysplastic nodules, and are useful for estimation of histological grading in HCCs [4,6]. Several authors have reported the presence of Kupffer cells in HCCs, especially in wHCC, but these can be confused with benign nodules in SPIO-enhanced MRI [2,4]. The characterisation of focal liver lesions by means of PSIL is considered problematic because the PSILs from several lesion types show an overlap [7,[11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…The signal intensity of each lesion by using a ROI was measured three times by the same radiologist with 1 week intervals, and the results were averaged. The ROIs of adjacent liver parenchyma of at least 200 mm 2 were placed in line with the lesion along the phase-encoding axis that is devoid of large vessels. The signal intensities on both T2WI/FS-T2WI of the lesions before and 10 min after contrast injection were recorded.…”

Section: Quantitative Imaging Analysismentioning

confidence: 99%

See 1 more Smart Citation

Percentage of signal intensity loss for characterisation of focal liver lesions in patients with chronic liver disease using ferucarbotran-enhanced MRI

Ct¹,

Rc²,

Chen³

et al. 2010

BJR

View full text Add to dashboard Cite

ABSTRACT. The purpose of this study was to determine the percentage of signal intensity loss (PSIL) threshold for the characterisation of focal liver lesions among patients with chronic liver disease. 55 nodules in 49 patients with chronic liver disease who underwent ferucarbotran-enhanced MR studies were included. Among the 49 patients, 40 had liver cirrhosis and 9 had chronic hepatitis. 8 haemangiomas, 3 focal nodular hyperplasia, 9 dysplastic nodules and 12 well, 19 moderately and 4 poorly differentiated hepatocellular carcinomas (HCCs) were revealed. The PSIL, signal-to-noise ratio and contrast-to-noise ratio of each lesion type were calculated. The diagnostic performance of PSIL on ferucarbotran-enhanced T 2 weighted images (PSIL T2WI ) and T 2 weighted fat-suppression images (PSIL FS-T2WI ) that characterised hepatic tumours was compared with receiver operating characteristic (ROC) analysis. Using ROC analysis, the diagnostic performance of PSIL FS-T2WI was superior to that of PSIL T2WI (p50.01). The mean PSIL FS-T2WI of the benign lesions was significantly higher than that of HCC (p,0.001), and the mean PSIL FS-T2WI of well-differentiated HCC was significantly higher than that of moderately/poorly differentiated HCCs (p50.001). With a PSIL FS-T2WI threshold of 40% in lesions characterising ferucarbotran-enhanced FS-T2WI, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 88.6%, 95%, 90.9%, 96.9% and 82.6%, respectively. In conclusion, with ferucarbotran-enhanced FS-T2WI, a PSIL FS-T2WI threshold of 40% for characterising focal liver nodules among patients with chronic liver disease is recommended. It is useful for distinguishing HCC from benign nodules.

show abstract

Dynamic Contrast-Enhanced MRI in the Liver

Jackson

Nicholson

Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology

View full text Add to dashboard Cite

Assessment of Kupffer cells by ferumoxides-enhanced MR imaging is beneficial for diagnosis of hepatocellular carcinoma: comparison of pathological diagnosis and perfusion patterns assessed by CT hepatic arteriography and CT arterioportography

Cited by 26 publications

References 30 publications

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Percentage of signal intensity loss for characterisation of focal liver lesions in patients with chronic liver disease using ferucarbotran-enhanced MRI

Dynamic Contrast-Enhanced MRI in the Liver

Contact Info

Product

Resources

About