Dynamic Contrast-Enhanced MRI in the Liver

Jackson, Alan; Nicholson, D A

doi:10.1007/3-540-26420-5_14

Cited by 9 publications

(10 citation statements)

References 75 publications

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“…In recent years, the combination of PET with magnetic resonance imaging (MRI) gains interest since MRI has several advantages over CT such as a better soft tissue contrast, the lack of ionizing radiation as well as the possibility to apply the entire range of all different contrast mechanism developed in the field of MRI (e.g. dynamic contrast enhancement (DCE) MRI (Jackson et al 2005), functional MRI (fMRI), BOLD (Ogawa et al 1990), CEST (Walker-Samuel et al 2013), IRON (Stuber et al 2007), chemical shift imaging (Brateman 1986)). To benefit from this combination to the highest extent, both imaging devices have to work simultaneously to facilitate e.g.…”

Section: Introductionmentioning

confidence: 99%

MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers

et al. 2015

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PET (positron emission tomography) with its high sensitivity in combination with MRI (magnetic resonance imaging) providing anatomic information with good soft-tissue contrast is considered to be a promising hybrid imaging modality. However, the integration of a PET detector into an MRI system is a challenging task since the MRI system is a sensitive device for external disturbances and provides a harsh environment for electronic devices. Consequently, the PET detector has to be transparent for the MRI system and insensitive to electromagnetic disturbances. Due to the variety of MRI protocols imposing a wide range of requirements regarding the MR-compatibility, an extensive study is mandatory to reliably assess worst-case interference phenomena between the PET detector and the MRI scanner. We have built the first preclinical PET insert, designed for a clinical 3 T MRI, using digital silicon photomultipliers (digital SiPM, type DPC 3200-22, Philips Digital Photon Counting). Since no thorough interference investigation with this new digital sensor has been reported so far, we present in this work such a comprehensive MR-compatibility study. Acceptable distortion of the B0 field homogeneity (volume RMS = 0.08 ppm, peak-to-peak value = 0.71 ppm) has been found for the PET detector installed. The signal-to-noise ratio degradation stays between 2-15% for activities up to 21 MBq. Ghosting artifacts were only found for demanding EPI (echo planar imaging) sequences with read-out gradients in Z direction caused by additional eddy currents originated from the PET detector. On the PET side, interference mainly between the gradient system and the PET detector occurred: extreme gradient tests were executed using synthetic sequences with triangular pulse shape and maximum slew rate. Under this condition, a relative degradation of the energy (⩽10%) and timing (⩽15%) resolution was noticed. However, barely measurable performance deterioration occurred when morphological MRI protocols are conducted certifying that the overall PET performance parameters remain unharmed.

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Section: Introductionmentioning

confidence: 99%

MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers

et al. 2015

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“…T 1 -weighted dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has been used in the assessment of a wide variety of tumors. A number of researchers have shown its potential in grading of gliomas (2)(3)(4)(5)(6). However, the quantification of perfusion metrics using DCE-MRI is not straightforward.…”

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confidence: 99%

Subcompartmentalization of extracellular extravascular space (EES) into permeability and leaky space with local arterial input function (AIF) results in improved discrimination between high‐ and low‐grade glioma using dynamic contrast‐enhanced (DCE) MRI

Sahoo

Rathore

Awasthi

et al. 2013

Magnetic Resonance Imaging

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“…In general terms, DCE-derived quantitative parameters reflect microcirculatory structure and function ( 19 ) , Ktrans correlating with vascularity markers such as vascular endothelial growth factor ( 4 ) and Ve correlating with histological estimates of EES volume ( 5 , 6 , 18 ) . The Ktrans depends on vascular surface area and flow ( 20 , 21 ) . Therefore, when there is high permeability, the influx of contrast is limited only by flow, whereas low permeability impedes the passage of contrast into the EES ( 22 ) .…”

Section: Discussionmentioning

confidence: 99%

Perfusion-weighted imaging in vestibular schwannoma: the influence that cystic status and tumor size have on perfusion profiles

et al. 2023

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Objective: The perfusion profile of vestibular schwannomas (VSs) and the factors that influence it have yet to be determined. Materials and Methods: Twenty patients with sporadic VS were analyzed by calculating parameters related to the extravascular extracellular space (EES)—the volume transfer constant between a vessel and the EES (Ktrans); the EES volume per unit of tissue volume (Ve); and the rate transfer constant between EES and blood plasma (Kep)—as well as the relative cerebral blood volume (rCBV), and by correlating those parameters with the size of the tumor and its structure (solid, cystic, or heterogeneous). Results: Although Ktrans, Ve, and Kep were measurable in all tumors, rCBV was measurable only in large tumors. We detected a positive correlation between Ktrans and rCBV (r = 0.62, p = 0.031), a negative correlation between Ve and Kep (r = –0.51, p = 0.021), and a positive correlation between Ktrans and Ve only in solid VSs (r = 0.64, p = 0.048). Comparing the means for small and large VSs, we found that the former showed lower Ktrans (0.13 vs. 0.029, p < 0.001), higher Kep (0.68 vs. 0.46, p = 0.037), and lower Ve (0.45 vs. 0.83, p < 0.001). The mean Ktrans was lower in the cystic portions of cystic VSs than in their solid portions (0.14 vs. 0.32, p < 0.001), as was the mean Ve (0.37 vs. 0.78, p < 0.001). There were positive correlations between the solid and cystic portions for Ktrans (r = 0.71, p = 0.048) and Kep (r = 0.74, p = 0.037). Conclusion: In VS, tumor size appears to be consistently associated with perfusion values. In cystic VS, the cystic portions seem to have lower Ktrans and Ve than do the solid portions.

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Dynamic Contrast-Enhanced MRI in the Liver

Cited by 9 publications

References 75 publications

MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers

MR-compatibility assessment of the first preclinical PET-MRI insert equipped with digital silicon photomultipliers

Subcompartmentalization of extracellular extravascular space (EES) into permeability and leaky space with local arterial input function (AIF) results in improved discrimination between high‐ and low‐grade glioma using dynamic contrast‐enhanced (DCE) MRI

Perfusion-weighted imaging in vestibular schwannoma: the influence that cystic status and tumor size have on perfusion profiles

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