Assessment of intrarenal perfusion with radioxenon:A critical review of analytical factors and their implications in man

Hollenberg, Norman K.; Mangel, R; Fung, H.

doi:10.1016/s0001-2998(76)80004-9

Cited by 42 publications

(15 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 Because blood flow is registered as milliliters per 100 grams per minute with this method, no further adjustment for kidney size or body size is necessary. This method requires injection of the tracer directly into the renal artery, which we accomplished in potential kidney donors at the time of the renal arteriogram that is required for kidney donation.…”

mentioning

confidence: 99%

Obesity, Salt Intake, and Renal Perfusion in Healthy Humans

Porter

Hollenberg

1998

Hypertension

View full text Add to dashboard Cite

Abstract-Renal perfusion rises as obesity develops during short-term overfeeding in animal studies. In humans, the assessment is complicated by the need to normalize renal perfusion for body size. We made use of the fact that radioactive xenon washout measures renal perfusion per unit of tissue mass to address this issue by comparing 45 moderately obese and 147 lean healthy potential kidney donors. All were disease free. The rationale for involving kidney donors reflects the fact that the xenon method for measuring renal perfusion demands injection of the xenon directly into the renal artery, which can be accomplished during the arteriogram that is a necessary part of potential kidney donor evaluation. In 21 obese subjects (body mass index [BMI], 29.1Ϯ0.9) in balance on a 10-mmol sodium intake, renal perfusion (352Ϯ16 mL ⅐ 100 g Ϫ1 ⅐ min Ϫ1) was significantly higher than predicted from findings in the 95 lean control subjects (313Ϯ3 mL ⅐ 100 g Ϫ1 ⅐ min Ϫ1 ; Pϭ0.035) after adjustment for age. With a high sodium intake (200 mmol), however, renal perfusion was not significantly different in 24 obese subjects (BMI, 28.8Ϯ0.7; 323Ϯ13 mL ⅐ 100 g Ϫ1 ⅐ min Ϫ1) in comparison to 52 lean controls (341Ϯ10 mL ⅐ 100 g Ϫ1 ⅐ min Ϫ1 ) after adjustment for age. Systolic and diastolic blood pressures were similar in obese and age-and gender-matched lean control subjects. Renal vasodilation was seen in association with sustained obesity in humans. While the mechanisms of obesity-related vasodilation are unclear, the dependence on sodium intake in this study is consistent with a role for the renin-angiotensin system. The findings are not in accordance with a reduction in renal perfusion reported in healthy obese humans in whom measured renal perfusion was indexed for body size. (Hypertension. 1998;32:144-148.)

show abstract

mentioning

confidence: 99%

Obesity, Salt Intake, and Renal Perfusion in Healthy Humans

Porter

Hollenberg

1998

Hypertension

View full text Add to dashboard Cite

show abstract

“…There are, however, further objections to justifying the technique even on empirical grounds. The interlobular artery supplies branches to glomeruli in the juxtamedullary region before supplying the glomeruli of the outer cortex, yet auto radiographic studies in animals using 85krypton imply that the outer cortex is perfused first and then the juxtaglomerular region (Thorburn, Kopald, Herd, Hollenberg, O'Marchoe & Barger, 1963;Hollenberg, Mangel & Fung, 1976 (Glass & de Garetta, 1971). Measurements derived from the second component vary inversely with those derived from the first component in results from normal kidneys and measurements from the first component correlate with cortical flow as assessed by a technique using microspheres (Slotkoff, Logan, Jose, D'Avella & Eisner, 1971).…”

Section: Gas Washout Methodsmentioning

confidence: 99%

Methods for the assessment of the effects of drugs on renal blood flow.

Pearson

1979

Brit J Clinical Pharma

View full text Add to dashboard Cite

“…15 The 133 Xenon washout curves were analyzed as described earlier. [15][16][17][18] In brief, after subtraction of background radiation, the disappearance of 133 Xenon from the kidney, measured by an extracorporeal gamma-probe, is analyzed mathematically by means of a 2-phase exponential decay. Occasionally, a monophasic decline in activity is observed and the curve analyzed accordingly.…”

Section: Intra-arterial 133 Xenon Washout Techniquementioning

confidence: 99%

“…The MRBF is calculated as the weighted average of the fast and the slow components. 18 All analyses were performed with the use of Prism 3.0 software.…”

Section: Intra-arterial 133 Xenon Washout Techniquementioning

confidence: 99%

Phase-Contrast Magnetic Resonance Flow Quantification in Renal Arteries

et al. 2003

View full text Add to dashboard Cite

Abstract-To assess the accuracy of 2D phase-contrast magnetic resonance (2D PC MR) renal artery flow measurements, data obtained with this technique were compared with those acquired with the 133 Xenon-washout procedure. In addition, the 2D PC MR flow data were related to functional renal information as derived from selective arterial and venous renin sampling. In 53 patients suspected of having renovascular hypertension, MR angiography of the renal arteries was performed, followed by a 3-step angiographic procedure: (1) selective venous and arterial renin sampling; (2) assessment of the renal blood flow by means of the 133 Xenon washout technique, and (3) conventional renal angiography. After initial assessment, 71 kidneys were left for analysis. The overall prevalence of renovascular disease Ն50% stenosis was 18%. Mean renal blood flow as assessed with the 2D PC MR technique showed a significant correlation with the 133 Xenon washout flow measurements, with a Pearson correlation coefficient of 0.69 (2-tailed; PϽ0.01). PC MR blood flow measurements correlated poorly with the presence and/or severity of renovascular disease on conventional angiography (rϭ0.1, Pϭ0.36). Likewise, no statistically significant correlation with either renal venous renin levels or the renin ratio could be identified. Measurement of renal artery blood flow with the use of a 2D PC MR technique is technically feasible. However, the mean renal artery blood flow correlates poorly with either the presence of renovascular disease on angiography or with renin levels. Further improvement of this technique is necessary before it can be applied on a larger scale.

show abstract

Assessment of intrarenal perfusion with radioxenon:A critical review of analytical factors and their implications in man

Cited by 42 publications

References 48 publications

Obesity, Salt Intake, and Renal Perfusion in Healthy Humans

Obesity, Salt Intake, and Renal Perfusion in Healthy Humans

Methods for the assessment of the effects of drugs on renal blood flow.

Phase-Contrast Magnetic Resonance Flow Quantification in Renal Arteries

Contact Info

Product

Resources

About