Assessment of insulin resistance in normoglycemic young adults

Preethi, B.; Jaisri, G; Kumar, K M Prasanna; Sharma, Rajeev

doi:10.1134/s0362119711010154

Cited by 7 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, significantly increased T3 in the PCOS patients compared with the control we studied exclude iodine insufficiency as a probable cause of thyroid over activity in the first group. Moreover, fasting insulin and glucose levels, if assessed among the studied groups, could have indicated the state of insulin sensitivity/resistance among PCOS patients we evaluated [21]. …”

Section: Discussionmentioning

confidence: 99%

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS).MethodsA case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered using a questionnaire. Thyroid hormones (thyroid-stimulating hormone, free tri-iodothyronine, and free thyroxine), anti-thyroid peroxidase, and anti-thyroglobulin antibodies were measured.ResultsWhile there were no significant differences in the age and haemoglobin levels of the two studied groups (55 women in each arm), body mass index was significantly higher in women with PCOS. There were no significant differences in the levels of thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone, luteinizing hormone/follicle stimulating hormone, anti-thyroid peroxidase, anti-thyroglobulin antibodies, cholesterol, triglycerides and low-density lipoprotein cholesterol between the cases and the controls. The mean±standard deviation of free tri-iodothyronine (3.50±0.2 vs. 3.38±0.3 pg/mL, P=0.040) and median (interquartile) high-density lipoprotein cholesterol (37.0 [34.0 to 42.0] vs. 35.80 [29.0 to 41.0] mg/dL, P=0.015) were significantly higher in PCOS patients compared with the control group. In linear regression, PCOS (0.151 pg/mL, P=0.023) and anti-thyroid peroxidase levels (-0.078 pg/mL, P=0.031) were significantly associated with free tri-iodothyronine.ConclusionFree tri-iodothyronine was a significantly higher among PCOS patients compared with the control group.

show abstract

Section: Discussionmentioning

confidence: 99%

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

et al. 2017

View full text Add to dashboard Cite

show abstract

“…A rapid and reliable laboratory test for detection of insulin levels in serum can be helpful to diagnose diabetes in its early stages. 1,2 …”

mentioning

confidence: 99%

Insulin-binding aptamer-conjugated graphene oxide for insulin detection

Zhu

Han

et al. 2011

Analyst

113

View full text Add to dashboard Cite

show abstract

“…This result indicates that although T3 of HOMA-IR was categorized as insulin sensitive due to its normal glucose level, it was somewhat closer to insulin resistance condition than T1. Therefore, T3 of HOMA-IR can be referred to as the early condition of insulin resistance (Preethi et al 2011). These results suggest that galnt2 and sirt1 expression can be used as markers of the early condition of insulin resistance.…”

Section: Resultsmentioning

confidence: 83%

“…In people with a normal BMI, NAFLD is more commonly found in Asian populations and is referred to as a "metabolically obese" condition (Wong and Ahmed 2014). Therefore, the early detection of insulin resistance and NAFLD prior to diagnosis is important to prevent the future risk of developing chronic diseases (Preethi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population

Limantara

Kartawidjajaputra

Suwanto

2018

Indones. J. Biotechnol.

View full text Add to dashboard Cite

Early detection of insulin resistance (IR) or non-alcoholic fatty liver disease (NAFLD) is crucial to preventing future risks of developing chronic diseases. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Liver Fat Score (LFS), and Fatty Liver Index (FLI) are generally employed to measure severity stages of IR and NAFLD. The study of gene expressions could explain the molecular mechanisms that occur early on in IR and NAFLD; thus providing potential early markers for both diseases. This study was conducted to evaluate the gene expressions that could potentially be early markers of IR and NAFLD. All participants (n = 21) had normal blood glucose and were categorized as without hepatosteatosis (n = 10), at higher risk of hepatosteatosis (n = 6), and hepatosteatosis (n = 5). Gene expression analysis was performed using the 2-∆∆CT relative quantification method. There were significant differences in galnt2 (p < 0.002) and sirt1 (p < 0.010) expression between the first and the third tertiles of HOMA-IR; and in ptpn1 (p < 0.012) expression between the first and the second tertiles of LFS. In conclusion, the expressions of galnt2 and sirt1 could be used as early markers of IR, while the expression of ptpn1 could be employed as an early marker of NAFLD.

show abstract

Assessment of insulin resistance in normoglycemic young adults

Cited by 7 publications

References 28 publications

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

Thyroid function/antibodies in sudanese women with polycystic ovarian disease

Insulin-binding aptamer-conjugated graphene oxide for insulin detection

Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population

Contact Info

Product

Resources

About