Assessment of insulin like growth factor-1 and IGF binding protein-3 in healthy Indian girls from Delhi and their correlation with age, pubertal status, obesity and thyroid hormonal status

Marwaha, Raman K.; Garg, MK; Gupta, Sushil K.; Khurana, Abhilasha; Narang, Amit; Shukla, Manoj Kumar; Arora, Preeti; Chadha, Aditi; Nayak, Deb Datta; Manchanda, Rajkumar

doi:10.1515/jpem-2016-0359

Cited by 10 publications

(6 citation statements)

References 27 publications

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“…IGF-1 is a potential suppressor for GH. In addition, diet has been implicated as a regulator of IGF-1 levels so higher calorie intake and obesity can increase the level of IGF-1 [25,26]. Hyperinsulinemia, as a result of insulin resistance in central obesity, has a direct inhibitory effect on pituitary GH synthesis and release [24].…”

Section: Discussionmentioning

confidence: 99%

The association between obesity and height in adolescents

Mehrdad¹,

Hassanbeigi²,

Sedaghat³

et al. 2021

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Background. The prevalence of childhood obesity is increasing worldwide and can affect their linear growth through various mechanisms. Objectives. We aimed to investigate the association between obesity-related traits and height in adolescents. Material and methods. This was a categorized cross-sectional study carried out on 186 students (93 case and 93 control) 15 to 18 years of age who were randomly selected from three schools in Shiraz, Iran. Anthropometric indices including height, weight, body mass index (BMI), body fat percentage (BF) and body muscle percentage (BM) were measured. Statistical analysis was done by SPSS software (Version 16). A significance level was considered as being less than 0.05. Results. We found an inverse association for waist circumference (WC) and fat mass with height. In addition, there was a direct relationship between fat-free mass and trunk fat with height. The mean height of participants in the obesity group was significantly lower than the control group (p = 0.04). Participants in the obesity group had significant higher FM percentage (p < 0.001) and WC (p < 0.001) than the control group. There was a significant correlation between height and WC (p = 0.003), as well as between height and fat percentage (p < 0.001). We also found a direct relationship between fast-free mass and height (p < 0.001), as well as between trunk fat percentage and height (p = 0.026). We have suggested an equation to estimate adolescents' height based on the anthropometric indices. Conclusions. Adiposity, especially central adiposity, is adversely associated with height. However, muscle percentage might reinforce linear growth. Further studies are warranted to confirm this finding.

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Section: Discussionmentioning

confidence: 99%

The association between obesity and height in adolescents

Mehrdad¹,

Hassanbeigi²,

Sedaghat³

et al. 2021

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“…In addition, the plasma IGF-1 concentration increased with the increasing age. Recently, it was reported that IGF-1 was a good marker of bone maturity in humans (Masoud et al 2009;Sinha et al 2016;Jain et al 2017;Marwaha et al 2017;Tripathi et al 2017) as the concentration of IGF-1 had a positive correlation with the cervical vertebral maturation index stages. The pattern of IGF-1 in the serum and plasma were low in early life and peaked at puberty and declined afterward.…”

Section: Plasma Hormones Metabolites and Bone Metabolism Markersmentioning

confidence: 99%

Skeletal growth in cattle in response to nutritional and hormonal manipulation

Antari¹

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“…Data on the relationship between IGF-1 levels and weight in children are inconsistent. There are studies describing comparable [2], lower [29][30][31][32][33], or higher [3,20,[34][35][36][37][38][39][40][41] IGF-1 levels and higher IGF-2 levels [4] in obese children compared to their normal-weight peers. However, IGF-1 shows a tendency to drop in children with extremely high BMI values [39].…”

Section: Children's Weightmentioning

confidence: 99%

“…Higher insulin and IGF-1 levels in mid-childhood are associated with earlier puberty onset [20,50]-thelarche and menarche in girls and gonadarche in boys [34,52,56]-though there are reports describing no association [57]. The level of serum IGF-1 rises until about pubertal age, reaching a peak that is up to nine times higher than in 3-month-old babies [34] at about 11-16 years for girls, depending on the origin [29], with the mean level being slightly higher for boys [34] and eventually starting to decline [29,34]. This supports the statement of a correlation between the IGF-1 level and the onset of puberty, which is the main inhibitor of IGF-1 quantity.…”

Section: Impact Of Igf-1 and Igf-2 On Puberty In Childrenmentioning

confidence: 99%

IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review

Szydlowska-Gladysz,

Gorecka,

Stepien

et al. 2024

IJMS

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This study examines the impact of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor 2 (IGF-2) on various aspects of children’s health—from the realms of growth and puberty to the nuanced characteristics of metabolic syndrome, diabetes, liver pathology, carcinogenic potential, and cardiovascular disorders. A comprehensive literature review was conducted using PubMed, with a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method employing specific keywords related to child health, obesity, and insulin-like growth factors. This study reveals associations between insulin-like growth factor 1 and birth weight, early growth, and adiposity. Moreover, insulin-like growth factors play a pivotal role in regulating bone development and height during childhood, with potential implications for puberty onset. This research uncovers insulin-like growth factor 1 and insulin-like growth factor 2 as potential biomarkers and therapeutic targets for metabolic dysfunction-associated liver disease and hepatocellular carcinoma, and it also highlights the association between insulin-like growth factors (IGFs) and cancer. Additionally, this research explores the impact of insulin-like growth factors on cardiovascular health, noting their role in cardiomyocyte hypertrophy. Insulin-like growth factors play vital roles in human physiology, influencing growth and development from fetal stages to adulthood. The impact of maternal obesity on children’s IGF levels is complex, influencing growth and carrying potential metabolic consequences. Imbalances in IGF levels are linked to a range of health conditions (e.g., insulin resistance, glucose intolerance, metabolic syndrome, and diabetes), prompting researchers to seek novel therapies and preventive strategies, offering challenges and opportunities in healthcare.

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Assessment of insulin like growth factor-1 and IGF binding protein-3 in healthy Indian girls from Delhi and their correlation with age, pubertal status, obesity and thyroid hormonal status

Cited by 10 publications

References 27 publications

The association between obesity and height in adolescents

The association between obesity and height in adolescents

Skeletal growth in cattle in response to nutritional and hormonal manipulation

IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review

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