Assessment of inhibitory properties of flavonoid-rich fig (Ficus carica L.) peel extracts against tyrosinase, α-glucosidase, urease and cholinesterases enzymes, and relationship with antioxidant activity

Meziant, Leila; Bachir‐bey, Mostapha; Bensouici, Chawki; Saci, Fairouz; Boutiche, Malika; Louailèche, Hayette

doi:10.1016/j.eujim.2020.101272

Cited by 40 publications

(37 citation statements)

References 82 publications

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“…The extracts also had antibacterial properties along with antioxidant activity and were effective against methicillinsensitive Staphylococcus aureus, methicillin-resistant S. aureus and Escherichia coli. Fig peels have also shown high antioxidant activities in a recent study by Meziant et al (2021) using the DPPH and ABTS assay. They reported that the lowest IC 50 value was for the Azenjer cultivar extract, while Bakor Noir showed the highest IC 50 value (four times higher than Azenjer).…”

Section: Antioxidant Activity and Health Benefitsmentioning

confidence: 85%

“…Fig peels have also shown high antioxidant activities in a recent study by Meziant et al . (2021) using the DPPH and ABTS assay. They reported that the lowest IC 50 value was for the Azenjer cultivar extract, while Bakor Noir showed the highest IC 50 value (four times higher than Azenjer ).…”

Section: Antioxidant Activity and Health Benefitsmentioning

confidence: 99%

“…Fig flavonoid extracts possess antihyperglycaemic activities as they inhibit the activity of enzymes such as α‐amylase and α‐glucosidase enzymes (Meziant et al ., 2021). This inhibition lowers the postprandial hyperglycaemia which is a crucial step in the treating diabetes as well as its complications (Hssaini et al ., 2020).…”

Section: Antioxidant Activity and Health Benefitsmentioning

confidence: 99%

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Polyphenols in fig: a review on their characterisation, biochemistry during ripening, antioxidant activity and health benefits

Singh

Kaur

2022

Int J of Food Sci Tech

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Fig fruit (consumed either fresh or dried) is a rich source of polyphenols distributed throughout its peel and pulp. However, the peel part is superior in diversity of these compounds in comparison to the pulp. Fig polyphenols have been extracted both by conventional solid-liquid extraction and novel assisted methods (mainly ultrasound-assisted and microwave-assisted procedures). These can be characterised primarily into flavonoids (anthocyanins, flavan-3-ols and various flavonol glycosides) and phenolic acids. Figs contain good levels of anthocyanins (such as cyanidin-3-O-glucoside, cyanidin-3,5-diglucoside and cyanidin-3-O-rutinoside) which impart different colouring hues to these fruits during the ripening process. Moreover, fig polyphenols have associated antioxidant activities and impart many health benefits such as antihyperglycaemic, hepatoprotective and antispasmodic activities. This review provides a thorough information on the fig polyphenols, stressing on their extraction, characterisation as well as quantification, the biochemical changes during the ripening process, associated antioxidant activity and health benefits.

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Section: Antioxidant Activity and Health Benefitsmentioning

confidence: 85%

Section: Antioxidant Activity and Health Benefitsmentioning

confidence: 99%

Section: Antioxidant Activity and Health Benefitsmentioning

confidence: 99%

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Polyphenols in fig: a review on their characterisation, biochemistry during ripening, antioxidant activity and health benefits

Singh

Kaur

2022

Int J of Food Sci Tech

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“…Our study shows evidence of AChE inhibition activity by VGSE in vitro, which agrees with previous studies 35 – 37 . The mechanism(s) of inhibition can be due to the interaction of phenolic compounds with the active site of the enzyme as discussed above for tyrosinase and α-amylase 38 .…”

Section: Resultsmentioning

confidence: 99%

Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities

Habib

El‐Fakharany

Kheadr

et al. 2022

Sci Rep

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Grape seed extract from (Vitis vinifera) (VGSE) is an excellent source of various polyphenols that exhibit highly potent antioxidant and disease prevention properties. Although numerous biological activities, with potential for improving human health, have been reported for VGSE, there is a lack of data relating to the health benefits of VGSE on DNA damage, protein damage, labile iron activity, and enzyme inhibitory effects. This investigation demonstrated, for the first time, that VGSE inhibits DNA and BSA damage and labile iron activity in-vitro. Moreover, VGSE also inhibited in-vitro activities of AChE, tyrosinase, and α-amylase. VGSE treatment significantly reduced viability of MCF-7, Hep-G2, Caco-2, and Huh-7 cells after 48-h treatments. The results obtained provide additional support for the purported health benefits of VGSE and reinforce its potential in disease prevention and therapy, especially in relation to cancer.

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“…Melanin has primarily a photoprotective role in human skin while its accumulation may result in skin hyperpigmentation. Therefore, the tyrosinase activity inhibition is considered as an interesting way to regulate melanogenesis [9]. Most drugs contain sulfur [10], oxygen and nitrogen [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Predictions of Drug-Likeness and Pharmacokinetic Properties of Some Chiral Thioureas as Potent Enzyme Inhibition Agents

2021

Turk J Chem

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A series of chiral thioureas (1-17) were synthesized from and tested for their anticholinesterase, tyrosinase and urease enzyme inhibitor activities. Various phenylisothiocyanates were added to solution of ʟ-cysteine in methanol:water (1:1 v/v) at room temperature and stirred for 24h. Precipitated solid was recrystallized from nbutanol. Pure compounds were characterized by NMR ( 1 H and 13 C), FTIR and CHNS. Tertiary amine containing N-(4-(diethylamino)phenyl)-N'-(2-mercapto-1carboxyethanyl)thiourea 17, N-(4-(dimethylamino)phenyl)-N'-(2-mercapto-1carboxyethanyl)thiourea 16 and trimethoxy containing N-(3,4,5-trimethoxyphenyl)-N'-(2-mercapto-1-carboxyethanyl)thiourea 14 were more active than galantamine against AChE and BChE enzymes. In tyrosinase enzyme inhibition activity, compound 14, 10, 12, 6, 13, and 11 exhibited higher tyrosinase inhibitory activity showing IC50 values of 1.1±0.1, 1.5±0.3, 1.6±0.6, 1.9±0.5, 2.2±0.9 and 2.9±0.2 mM, respectively. In urease enzyme inhibition activity assay, 17 showed higher activity. This work demonstrates the pharmacological significance of chiral thiourea derivatives synthesized from ʟ-cysteine and showing their potential. There is a need to perform more in vitro and in vivo biological activities followed by clinical trials to bring such thiourea to the market.

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Assessment of inhibitory properties of flavonoid-rich fig (Ficus carica L.) peel extracts against tyrosinase, α-glucosidase, urease and cholinesterases enzymes, and relationship with antioxidant activity

Cited by 40 publications

References 82 publications

Polyphenols in fig: a review on their characterisation, biochemistry during ripening, antioxidant activity and health benefits

Polyphenols in fig: a review on their characterisation, biochemistry during ripening, antioxidant activity and health benefits

Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities

Synthesis, Predictions of Drug-Likeness and Pharmacokinetic Properties of Some Chiral Thioureas as Potent Enzyme Inhibition Agents

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