“…For brain imaging, the robust assessment of cerebral blood volume (CBV) and oxygenation, derived from the measure of hemoglobin concentrations in the brain, is essential for reliable cross-sectional and longitudinal studies of health, disease, and disease progression. 8,9,[19][20][21][22] Continuous-wave methods, such as broadband or hyperspectral approaches originally proposed more than 15 years ago, 2 require spatially 1 or spectrally [2][3][4][5] resolved information in order to disentangle the contributions from tissue absorption and scattering. The frequency-domain multidistance (FDMD) approach based on a homogeneous model 6 has been extensively validated with Monte Carlo simulations, 14 phantoms, 6,12 and animal models.…”