Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy

Arri, S. J.; Muehlemann, Thomas; Biallas, Martin; Bucher, Hans Ulrich; Wolf, M.

doi:10.1117/1.3570303

Cited by 46 publications

(40 citation statements)

References 24 publications

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“…[56][57][58][59] However, these studies failed to match infants according to postconceptional or term-equivalent age, so age-related differences were likely to be obscured by the range of developmental stages. [56][57][58][59] Lower cerebral TOI in preterm infants compared with term infants may be due to inadequate cerebral oxygen delivery relative to consumption. 22 Impaired oxygen carrying capacity because of anemia, which is likely to be more severe in preterm infants, as mentioned previously, may contribute to this mismatch.…”

Section: Effects Of Preterm Birthmentioning

confidence: 99%

Cerebral Oxygenation in Preterm Infants

et al. 2014

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BACKGROUND AND OBJECTIVE: Prone sleeping is a major risk factor for sudden infant death syndrome (SIDS) and preterm infants are at significantly increased risk. In term infants, prone sleeping is associated with reduced mean arterial pressure (MAP) and cerebral tissue oxygenation index (TOI). However, little is known about the effects of sleeping position on TOI and MAP in preterm infants. We aimed to examine TOI and MAP in preterm infants after term-equivalent age, during the period of greatest SIDS risk. METHODS: Thirty-five preterm and 17 term infants underwent daytime polysomnography, including measurement of TOI (NIRO-200 spectrophotometer, Hamamatsu Photonics KK, Japan) and MAP (Finapress Medical Systems, Amsterdam, Netherlands) at 2 to 4 weeks, 2 to 3 months, and 5 to 6 months postterm age. Infants slept prone and supine in active and quiet sleep. The effects of sleep state and position were determined by using 2-way repeated measures analysis of variance and of preterm birth by using 2-way analysis of variance. RESULTS: In preterm infants, TOI was significantly lower when prone compared with supine in both sleep states at all ages (P < .05). Notably, TOI was significantly lower in preterm compared with term infants at 2 to 4 weeks, in both positions (P < .05), and at 2 to 3 months when prone (P < .001), in both sleep states. MAP was also lower in preterm infants in the prone position at 2 to 3 months (P < .01). CONCLUSIONS: Cerebral oxygenation is reduced in the prone position in preterm infants and is lower compared with age-matched term infants, predominantly in the prone position when MAP is also reduced. This may contribute to their increased SIDS risk.

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Section: Effects Of Preterm Birthmentioning

confidence: 99%

Cerebral Oxygenation in Preterm Infants

et al. 2014

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“…Thus this symmetrical geometry is indeed selfcalibrating and at the same time reduces the influence of superficial inhomogeneities and light coupling. 8 In a first step to obtain the StO 2 , according to the diffusion approximation S is converted into the product of light absorption (μ a ) and scattering (μ s ): 5 We also corrected for the absorption of water by assuming that the concentration of water is 90%. The algorithm was implemented in a MATLAB R script and used offline to calculate StO 2 .…”

Section: Nirs Measurementmentioning

confidence: 99%

“…This was considered as insufficient for clinical purposes. 4 Arri et al 5 obtained a reproducibility of 4.6% for the OxiplexTS (ISS, Champaign, Illinois) and determined that low reproducibility is associated with inhomogeneous tissue.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants

et al. 2011

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Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO(2)) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO(2) measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO(2) measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO(2) was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., 5% reproducibility for the NIRO 300. The novel StO (2) Abstract. Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO 2 ) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO 2 measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO 2 measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO 2 was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300.

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“…We used the absorption coefficients from Matcher et al [12], averaged over the measured intensity spectrum of each light source. Coefficients for scattering were taken from Matcher et al [13] for the adult arm and from ISS OxyPlex measurements on 36 term infants [14] for the neonates, extrapolated to 750nm, 800nm and 875nm (3.81, 3.49 and 3.01[cm …”

Section: Methodsmentioning

confidence: 99%

The Effect of Basic Assumptions on the Tissue Oxygen Saturation Value of Near Infrared Spectroscopy

Metz

Biallas

Jenny

et al. 2012

Advances in Experimental Medicine and Biology

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Tissue oxygen saturation (StO(2)), a potentially important parameter in clinical practice, can be measured by near infrared spectroscopy (NIRS). Various devices use the multi-distance approach based on the diffusion approximation of the radiative transport equation [1,2]. When determining the absorption coefficient ( (a)) by the slope over multiple distances a common assumption is to neglect (a) in the diffusion constant, or to assume the scattering coefficient [Formula: see text] to be constant over the wavelength. Also the water influence can be modeled by simply subtracting a water term from the absorption. This gives five approaches A1-A5. The aim was to test how these different methods influence the StO(2) values. One data set of 30 newborn infants measured on the head and another of eight adults measured on the nondominant forearm were analyzed. The calculated average StO (2) Abstract Tissue oxygen saturation (StO 2 ), a potentially important parameter in clinical practice, can be measured by near infrared spectroscopy (NIRS). Various devices use the multi-distance approach based on the diffusion approximation of the radiative transport equation [1,2]. When determining the absorption coefficient (µ a ) by the slope over multiple distances a common assumption is to neglect µ a in the diffusion constant, or to assume the scattering coefficient (µ s ') to be constant over the wavelength. Also the water influence can be modelled by simply subtracting a water term from the absorption. This gives five approaches A1 to A5. The aim was to test how these different methods influence the StO 2 values. One data set of 30 newborn infants measured on the head and another of eight adults measured on the non-dominant forearm were analysed.

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Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy

Cited by 46 publications

References 24 publications

Cerebral Oxygenation in Preterm Infants

Cerebral Oxygenation in Preterm Infants

Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants

The Effect of Basic Assumptions on the Tissue Oxygen Saturation Value of Near Infrared Spectroscopy

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