Assessment of Human Herpes Virus 8 Infection among Breast Cancer Patients

Mohamed, Amira S.; Gomaa, Hanaa H. A.; Attia, Fadia M.

doi:10.20546/ijcmas.2017.610.081

Cited by 3 publications

(7 citation statements)

References 18 publications

(23 reference statements)

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“…Various studies have shown that the prevalence of viral infections in breast cancer patients is higher compared to the control group. A study by Amira S. Mohamed and colleagues showed that the HHV-8 virus genome was found in the blood of 28.8% of breast cancer patients [10]. While our results showed that the frequency of HHV-8 virus genome in breast cancer tissue samples was 12.38%.…”

Section: Discussioncontrasting

confidence: 66%

“…Studies have also shown that the HHV-8 has the ability to immortalize and transform breast cells by inhibiting apoptosis, inducing cell proliferation, cell survival, increasing angiogenesis, and modulating the immune system. In addition, the virus can induce tumor genesis by producing interleukin homologs [10].…”

Section: Discussionmentioning

confidence: 99%

“…The study by Tsai showed that the prevalence of HHV-8 in breast cancer patients is higher than other viruses [9]. Also, the Amira S. Mohamed study showed, 28.8% blood samples of breast cancer cases were positive for HHV-8 DNA [10].…”

Section: Introductionmentioning

confidence: 97%

“…Previous studies have shown that papillomavirus [5], Epstein-Barr virus (EBV) [2], mouse mammary tumor virus (MMTV) [6,7], and bovine leukemia virus (BLV) [8] are associated with an increased risk of breast cancer. Moreover, several recent studies have suggested a possible relationship between Human Herpes Virus-8 (HHV-8) and breast cancer [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation frequency of Human Herpes Virus type 8 in Patients with Breast Cancer

Fozuni

Arabzadeh

Mollaie

et al. 2020

Preprint

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Background Breast cancer is one of the most common malignancies and the most common cause of death women around worldwide. Recently, viral etiology theory has been proposed on physiopathology of the breast cancer. Method: In a retrospective study, to study of non-familial agents and a viral factors breast cancer, the Real time PCR were used to detect Kaposi Herpes virus or Human herpes virus type8(HHV8) in 138 patients with breast cancer. Result Out of the 138 embedded paraffin breast cancer tissues, 17(12.3%) were positive for HHV8. Among the viral positive breast cancer samples, 8 samples (10.95%) were positive in intermediate grade and 10 samples (11.9%) were positive in 40–60 years old age group. There was no significant relation between grades of tumors and there was a significant relation between age and breast cancer. Conclusion Out of 17 positive samples 15 samples (88.23%) and 2 samples (11.77%) had more than 5 and less than 3 infected lymph node. In this study, there was a significant relation between infected lymph node and positive samples with HHV-8. Therefore, it is likely that the lymphocytes infected with HHV-8 virus may be the source of cancer cells and may also cause infected cells to spread to other organs, as well as the treatment of these patients is difficult.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation frequency of Human Herpes Virus type 8 in Patients with Breast Cancer

Fozuni

Arabzadeh

Mollaie

et al. 2020

Preprint

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show abstract

“…Besides, according to the literature, HHV-8 can immortalize and transform breast cells by inhibiting apoptosis, inducing cell proliferation, enhancing cell survival, increasing angiogenesis, and modulating the immune system. Moreover, the virus can induce tumor genesis by producing interleukin homologs (8,9). Therefore, fighting against viruses is of particular importance in the body.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Herpes Virus 8 Infection and Pattern of TLR4 rs4986791 Polymorphism in Women with Breast Cancer

Hamta

Komijani

Hezaveh

2020

Jentashapir J Cell Mol Biol

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Background: Breast cancer is a major cause of female death worldwide. Several factors contribute to cancer development, one of the most important of which is viruses identified by the host immune system and Toll-like receptors (TLRs). Human herpes virus 8 (HHV-8) is one of the viruses with a proven role in Kaposi’s sarcoma development. Objectives: This study aimed to investigate the correlation between HHV-8 infection and breast cancer, as well as the role of rs4986791 polymorphism in women’s health. Methods: Blood samples of 80 healthy subjects and 80 patients suffering from breast cancer were collected (from May-September 2018). The presence of HHV-8 in the samples was examined by PCR. Also, the rs4986791 polymorphism was evaluated by nested PCR-RFLP. Results: The results showed a significant relationship between age and breast cancer. Of 80 cancer patients and 80 healthy subjects, 17 (21.3%) and 15 (18.8%) were carriers of HHV-8, respectively. Also, there was no significant relationship between HHV-8 infection and breast cancer (P = 0.693). We found no significant relationship between the presence of virus and cancer grade (P = 0.618). Conclusions: The results of rs498679 polymorphism analysis indicated that the T allele was associated with increased health phenotype and decreased risk of cancer development. Also, women with TT genotype exhibited significantly lower HHV-8 infection than the other genotypes.

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In situ Molecular Hybridization of Kaposi, s Sarcoma Associated Virus (Human Herpes Virus 8) in Nasopharyngeal Carcinoma Tissues

2021

IJFMT

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Background: Viral, dietary and genetic factors are implicated in the etiology ofnasopharyngeal cancer, a rare type of head and neck cancers. Unlike other viruses, HHV-8 encodes several human cytokines homologues and regulatory genes that play important roles in the viral pathogenesis.Objective: To analyze the rates of HHV-8 infection in tissues obtained from a group of patients with nasopharyngeal carcinoma and inflammatory nasal polyps (INP) . Patients and Method:One hundred-thirty formalin-fixed, paraffin-embedded nasopharyngeal carcinoma and nasal inflammatory polyps tissues enrolled in this study; 65 nasopharyngeal tissue biopsies from nasopharyngeal carcinoma; 35 tissue biopsies from nasal inflammatory polyps and 30 nasopharyngeal tissues with unremarkable pathological changes, as apparently healthy tissuecontrol. Detection of HHV-8 was done by chromogenic in situ hybridization (CISH) technique detection system.Results: In nasopharyngeal carcinoma tissues, the HHV-8-DNA positive CISH reactions were detected in 23.1% while in nasal inflammatory polyps tissues HHV-8-positive CISH reactions were found in 8.6% of the examined tissues. The correlation between HHV-8 and NPC & INP was highly significant (P= 0.001). Conclusion:Significant HHV-8 detection in nasopharyngeal carcinoma & inflammatory nasal polypstissues could point for their possible role in either pathogenesis or carcinogenesis of both these lesions.

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Assessment of Human Herpes Virus 8 Infection among Breast Cancer Patients

Cited by 3 publications

References 18 publications

Evaluation frequency of Human Herpes Virus type 8 in Patients with Breast Cancer

Evaluation frequency of Human Herpes Virus type 8 in Patients with Breast Cancer

Prevalence of Human Herpes Virus 8 Infection and Pattern of TLR4 rs4986791 Polymorphism in Women with Breast Cancer

In situ Molecular Hybridization of Kaposi, s Sarcoma Associated Virus (Human Herpes Virus 8) in Nasopharyngeal Carcinoma Tissues

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