Assessment of genetically modified maize MON 87427 × MON 87460 × MON 89034 × 1507 × MON 87411 × 59122 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2017‐139)

Abstract

Maize MON 87427 × MON 87460 × MON 89034 × 1507 × MON 87411 × 59122 (six‐event stack maize) was produced by conventional crossing to combine six single events: MON 87427, MON 87460, MON 89034, 1507, MON 87411 and 59122. The GMO Panel previously assessed the six single maize events and 17 of the subcombinations and did not identify safety concerns. No new data on the single maize events or the 17 subcombinations were identified that could lead to modification of the original conclusions on their safety. The molecular characterisation, comparative analysis (agronomic, phenotypic and compositional characteristics) and the outcome of the toxicological, allergenicity and nutritional assessment indicate that the combination of the single maize events and of the newly expressed proteins and dsRNA in the six‐event stack maize does not give rise to food and feed safety and nutritional concerns. The GMO Panel concludes that the six‐event stack maize, as described in this application, is as safe as its non‐GM comparator and the selected non‐GM reference varieties. In the case of accidental release of viable grains of the six‐event stack maize into the environment, this would not raise environmental safety concerns. The GMO Panel assessed the likelihood of interactions among the single events in the 39 maize subcombinations not previously assessed and concludes that these are expected to be as safe as the single events, the previously assessed subcombinations and the six–event stack maize. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of the six‐event stack maize. Post‐market monitoring of food/feed is not considered necessary. The GMO Panel concludes that the six‐event stack maize and its subcombinations are as safe as the non‐GM comparator and the selected non‐GM reference varieties with respect to potential effects on human and animal health and the environment.

Assessment of genetically modified maize DP4114 × MON 89034 × MON 87411 × DAS‐40278‐9 and subcombinations, for food and feed uses, under Regulation (EC) No 1829/2003 (application EFSA GMO‐NL‐2020‐171)

“…The updated bioinformatic analyses for maize events DP4114, MON 89034, MON 87411 and DAS-40278-9 confirm the assessments provided in the context of previous Scientific Opinions ( EFSA GMO Panel, 2021b, 2022a.…”

Assessment of genetically modified maize MON 89034 × 1507 × MIR162 × NK603 × DAS‐40278‐9 for food and feed uses, under regulation (EC) No 1829/2003 (application EFSA‐GMO‐NL‐2018‐151)

“…In accordance to Regulation (EU) No 503/2013, the applicant provided a 90‐day oral repeated‐dose toxicity study in rats on whole food and feed from each of the maize single event composing the five‐event stack maize. The GMO Panel had previously concluded that these studies are in line with Regulation (EU) No 503/2013 and do not show adverse effects related to diets incorporating the single‐event maize MON 89034 (EFSA GMO Panel, 2019e ), 1507 (EFSA GMO Panel, 2021a , b ), MIR162 (EFSA GMO Panel, 2019c ), NK603 (EFSA GMO Panel, 2019c ) and DAS‐40278‐9 (EFSA GMO Panel, 2021c ).…”

“…The applicant clarified that the maize 1507 sequence reported for the five‐event stack maize contained one silent nucleotide change in the insert sequence compared to the corrected original sequence (EFSA GMO Panel, 2017b ), that has already been assessed in the frame of previous applications (EFSA GMO Panel, 2018a , b , 2019b , c , 2021b ). Analysis of the new sequencing data and bioinformatic analyses performed on the new sequence does not identify any need for further safety assessment (EFSA GMO Panel, 2017b ).…”

Facultative symbionts are potential agents of symbiont-mediated RNAi in aphids

“…In 2018–2021, EFSA evaluated the safety of MON87411 with other GM corns for food and feed uses. EFSA concluded that MON87411 was safe, and no safety concern was identified ( EFSA Panel on Genetically Modified Organisms (GMO) et al, 2018 , 2019 , 2021 ). In 2021, the GMO safety certificate of MON87411 was approved by Ministry of Agriculture and Rural Affairs, PRC.…”