Assessment of ER, PR &amp; HER2-neu in carcinoma breast.

Tiwari, Neema; Gupta, Parul; Lal, Nirupma; Verma, Vidhi; Musa, Osman

doi:10.18535/ijmsci/v4i5.22

Cited by 4 publications

(6 citation statements)

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“…Authors (Year) Azizun-Nisa et al [5,7] (2008) Rao et al [6,7] (2020) Thiygarajan M et al [7] (2015) In the present study, grade of tumour is significantly associated with PR status. PR positivity is higher in grade I tumour (83.3%) as compared to grade II (66.7%) and grade III (48.6%) p = 0.03.…”

Section: Grade Hormonal Receptors Statusmentioning

confidence: 55%

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Comparison of ER, PR and HER-2/NEU reactivity pattern with histological grade, type, tumour size, Lymphovascular invasion, mitotic index and lymph node status in breast cancer

Payal¹,

Kirti²

2021

Int. J. Clin. Diagn. Pathol.

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Breast cancer prognosis is related to a variety of clinical, pathologic and molecular features which include classical prognostic factors viz. Histological grade, morphological type, tumour size, mitotic index, Lymphovascular invasion and lymph node metastases. Estrogen and progesterone receptors (ER, PR) and more recently, HER-2/neu have with increasing importance influenced the management of the malignancy. The presence of hormone receptors (ER and PR) in the tumour tissue correlates well with the response to hormone therapy and chemotherapy. Aims: To assess ER, PR and Her2neu status in breast cancer and to compare ER, PR and Her2neu status with other prognostic factors like tumour size, pathological type, histological grade, lymph node status, mitotic index and Lymphovascular invasion in breast cancer. Methods and materials: A total of 100 cases of breast cancer reported at pathology department during a period from January 2019 to August 2020 are enrolled in the study. Representative sections with tumour and the adjacent normal breast tissue (internal control) are processed for ER, PR and HER-2/neu immuno-histochemical staining. Tumour size, morphological type, Histological grading, Mitotic index, Lymphovascular invasion, Lymph Node status were studied. Results: Occurrence of breast carcinoma is higher in older women (> 50 years of age). The prevalence of ER, PR, HER-2/neu expression are high (ER-73.0%, PR -65.0% and HER-2/neu -28.0%). About 14.0% tumour are triple negative. Increased HER2/neu positivity is noticed in ER and PR negative tumours. Two third (66.0%) tumour's size is from 2 to 5 cm. Proportion of Grade II (39.0%) and Grade III tumour (37.0%) are high. Most common pathologic type of carcinoma is Infiltrating duct carcinoma, not otherwise specified (85.0%) followed by Mucinous carcinoma (5.0%), Invasive papillary carcinoma (4.0%) and Invasive lobular carcinoma (2.0%). PR positivity is increased with increasing tumour size. (p value = 0.01). PR positivity decreases with the increase in grade. (p value = 0.03). HER/ 2neu expression decreased with rising age. (p value = 0.03). Conclusion:The findings suggest that women in our population more often have histologically less aggressive breast carcinoma with a smaller number of triple negative tumours (14%), so they are likely to be more susceptible to conventional hormonal and targeted antibody treatment.

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Section: Grade Hormonal Receptors Statusmentioning

confidence: 55%

“…Its amplification and overexpression are associated with a poor prognosis in axillary lymph node ~ 109 ~ metastases, but there is no association with negative lymph nodes. HER2-neu may also be a predictive marker [6] .…”

Section: Introductionmentioning

confidence: 99%

Comparison of ER, PR and HER-2/NEU reactivity pattern with histological grade, type, tumour size, Lymphovascular invasion, mitotic index and lymph node status in breast cancer

Payal¹,

Kirti²

2021

Int. J. Clin. Diagn. Pathol.

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“…The most common histological type of breast carcinoma diagnosed in the present study was invasive ductal carcinoma (no special type) in 51 cases (92.72%). It was also reported as the predominant histological type in the studies by Bhagat et al 3 , Thiygarajan et al 16 , Tiwari et al 17 and Verma et al 14 as 94.82%, 84.3%, 81.17% and 87.5% respectively. In our study, majority of the cases presented with grade II tumors (61.82%), followed by grade I (21.82%) while least number of the patients belonged to grade III (16.36%).…”

Section: Discussionmentioning

confidence: 75%

“…In our study, majority of the cases presented with grade II tumors (61.82%), followed by grade I (21.82%) while least number of the patients belonged to grade III (16.36%). Grade II had also been observed as the most common grade by the studies of Nisa et al 18 (55.33%), Ahmed et al 19 (55.2%), Bhagat et al 3 (43.1%), Geethmala et al 20 (54.0%) and Tiwari et al 17 (68.7%).…”

Section: Discussionmentioning

confidence: 82%

Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

Juneja¹,

Agarwal²,

Agarwal³

et al. 2019

IJCMR

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Introduction: Breast carcinoma is the most common cancer among women in both developing and developed countries. It needs alarming attention because it causes high morbidity and mortality. There is a need to understand the initiation and progression of breast cancer on hormonal, cellular and molecular basis which forms the platform for designing of targeted therapy. This study was intended to find correlation between the expression of Estrogen receptor, Progesterone receptor and Human Epidermal Growth Factor Receptor-2 with histological grade in cases of carcinoma breast.

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“…The most common histological type of breast carcinoma diagnosed in the present study was invasive ductal carcinoma (not otherwise specified) in 46 cases (82.14%). It was also reported as the predominant histological type in the studies by Bhagat et al [6] , Thiygarajan et al [10] , Tiwari et al [8] and Verma et al [5] as 94.82%, 84.3%, 81.17% and 87.5% respectively.…”

Section: Methodsmentioning

confidence: 80%

Correlation of immunohistochemistry markers in breast carcinoma with biological characteristics and tumor grade as histopathological prognostic parameters

Sukhadia¹,

Banerji²,

Dobariya³

2021

Int. J. Clin. Diagn. Pathol.

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Background: Prognosis of breast cancer and success of therapeutic interventions largely rely on clinico-pathologic and biological characteristics of tumor and vary due to the heterogenous nature of breast cancers. This study was intended to find correlation between the expression of Estrogen receptor (ER), Progesterone receptor (PR) and Human Epidermal Growth Factor Receptor-2 (HER-2/neu) with histological grade in case of carcinoma of breast. Material and Method: This study was conducted on 56 histologically confirmed specimens of breast

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Assessment of ER, PR & HER2-neu in carcinoma breast.

Cited by 4 publications

References 0 publications

Comparison of ER, PR and HER-2/NEU reactivity pattern with histological grade, type, tumour size, Lymphovascular invasion, mitotic index and lymph node status in breast cancer

Comparison of ER, PR and HER-2/NEU reactivity pattern with histological grade, type, tumour size, Lymphovascular invasion, mitotic index and lymph node status in breast cancer

Correlation of Expression of Estrogen Receptor, Progesterone Receptor and Human Epidermal Growth Factor Receptor-2 with Histopathological Grade in Cases of Carcinoma Breast

Correlation of immunohistochemistry markers in breast carcinoma with biological characteristics and tumor grade as histopathological prognostic parameters

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