Assessment of equine fecal microbial profiles during and after a colic episode using pyrosequencing

Venable, E. B.; Kerley, M. S.; Raub, R. J. T

doi:10.1016/j.jevs.2013.03.066

Cited by 13 publications

(11 citation statements)

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“…At the genus level, overgrowth of Lactobacillus or Streptococcus was observed in horses with colic with large or small intestinal origin, respectively. Similar to the current findings, an increased abundance of lactic acid bacteria was reported to be a major cause of intestinal dysbiosis and colic [ 11 , 43 , 46 ]. Moreover, a decrease in pH may decrease the abundance of methanogens in intestinal disease horses [ 47 ].…”

Section: Discussionsupporting

confidence: 89%

Comparison of the Fecal Microbiota of Horses with Intestinal Disease and Their Healthy Counterparts

Park

Cheong

Yoon³

et al. 2021

Veterinary Sciences

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(1) Background: The intestinal microbiota plays an essential role in maintaining the host’s health. Dysbiosis of the equine hindgut microbiota can alter the fermentation patterns and cause metabolic disorders. (2) Methods: This study compared the fecal microbiota composition of horses with intestinal disease and their healthy counterparts living in Korea using 16S rRNA sequencing from fecal samples. A total of 52 fecal samples were collected and divided into three groups: horses with large intestinal disease (n = 20), horses with small intestinal disease (n = 8), and healthy horses (n = 24). (3) Results: Horses with intestinal diseases had fewer species and a less diverse bacterial population than healthy horses. Lactic acid bacteria, Lachnospiraceae, and Lactobacillaceae were overgrown in horses with large intestinal colic. The Firmicutes to Bacteroidetes ratio (F/B), which is a relevant marker of gut dysbiosis, was 1.94, 2.37, and 1.74 for horses with large intestinal colic, small intestinal colic, and healthy horses, respectively. (4) Conclusions: The overgrowth of two lactic acid bacteria families, Lachnospiraceae and Lactobacillaceae, led to a decrease in hindgut pH that interfered with normal fermentation, which might cause large intestinal colic. The overgrowth of Streptococcus also led to a decrease in pH in the hindgut, which suppressed the proliferation of the methanogen and reduced methanogenesis in horses with small intestinal colic.

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Section: Discussionsupporting

confidence: 89%

Comparison of the Fecal Microbiota of Horses with Intestinal Disease and Their Healthy Counterparts

Park

Cheong

Yoon³

et al. 2021

Veterinary Sciences

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“…Venable et al . characterised shifts in microbial populations during and after an episode of colic; nine unique taxa were identified in colic samples and 19 unique taxa were identified in post‐colic samples . Results of this study were the first to elucidate specific and rapid changes within the equine faecal microbiota associated with occurrence of and recovery from colic.…”

Section: Introductionmentioning

confidence: 86%

“…These findings further stimulate questions regarding whether these changes in the microbiota are a principle cause of colic or whether they indicate a subacute condition that later results in a clinical episode of GI disease. Venable et al characterised shifts in microbial populations during and after an episode of colic; nine unique taxa were identified in colic samples and 19 unique taxa were identified in post-colic samples [8].…”

Section: Introductionmentioning

confidence: 99%

Differences in the equine faecal microbiota between horses presenting to a tertiary referral hospital for colic compared with an elective surgical procedure

Stewart

Southwood

Indugu

et al. 2018

Equine Veterinary Journal

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Changes in bacterial populations in the faecal microbiota of horses presenting for colic observed in this study concurs with previous studies in veterinary and human patients with gastrointestinal disease. Future studies focusing on different causes of colic, chronic or recurrent disease, and the association with histological changes within the intestine are needed. This article is protected by copyright. All rights reserved.

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“…Currently only a few studies evaluating the effect of colic on equine gut microbiota exist. Venable, Kerley [145] reported increased Clostridium phytofermentans and Bacteroidetes in all samples from horses during the colic state compared to those post-colic (30-90 days following discharge). Weese, Holcombe [123] suggested an association exists between Firmicutes (particularly Lachnospiraceae and Ruminococcaceae family members)/Proteobacteria ratio and the onset of colic (the higher the ratio, the less likely colic is to develop), which can be potentially used to predict and prevent colic.…”

Section: Colicmentioning

confidence: 94%

Factors Influencing Equine Gut Microbiota: Current Knowledge

Garber

Hastie

Murray

2020

Journal of Equine Veterinary Science

105

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Gastrointestinal microbiota play a crucial role in nutrient digestion, maintaining animal health and welfare. Various factors may affect microbial balance often leading to disturbances that may result in debilitating conditions such as colic and laminitis. The invention of next generation sequencing technologies and bioinformatics has provided valuable information on the effects of factors influencing equine gut microbiota. Among those factors are nutrition and management (e.g. diet, supplements, exercise), medical substances (e.g. antimicrobials, anthelmintics, anaesthetics), animal-related factors (breed and age), various pathological conditions (colitis, diarrhoea, colic, laminitis, equine gastric ulcer syndrome) as well as stress-related factors (transportation and weaning). The aim of this review is to assimilate current knowledge on equine microbiome studies, focusing on the effect of factors influencing equine gastrointestinal microbiota. Decrease in microbial diversity and richness leading to decrease in stability; decrease in Lachnospiraceae and Ruminococcaceae family members, which contribute to gut homeostasis; increase in Lactobacillus and Streptococcus; decrease in lactic acid utilising bacteria; decrease in butyrate-producing bacteria that have anti-inflammatory properties may all be considered as a negative change in equine gut microbiota. Shifts in Firmicutes and Bacteroidetes have often been observed in the literature in response to certain treatments or when describing healthy and unhealthy animals; however, these shifts are inconsistent. It is time to move forward and use the knowledge now acquired to start manipulating the microbiota of horses.

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Assessment of equine fecal microbial profiles during and after a colic episode using pyrosequencing

Cited by 13 publications

References 0 publications

Comparison of the Fecal Microbiota of Horses with Intestinal Disease and Their Healthy Counterparts

Comparison of the Fecal Microbiota of Horses with Intestinal Disease and Their Healthy Counterparts

Differences in the equine faecal microbiota between horses presenting to a tertiary referral hospital for colic compared with an elective surgical procedure

Factors Influencing Equine Gut Microbiota: Current Knowledge

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