Assessment of dry eye signs and symptoms and ocular tolerance of a preservative-free lacrimal substitute (Hylabak®) versus a preserved lacrimal substitute (Systane®) used for 3 months in patients after LASIK

Abstract

Laser-assisted in situ keratomileusis (LASIK) is commonly used to correct refractive defects. The procedure frequently results in dry eye symptoms, usually of short but sometimes longer duration. This study was designed to assess dry eye and ocular tolerability after LASIK in patients treated with a preservative-free lacrimal substitute (Hylabak®) or preserved lacrimal substitute (Systane®). In a single-center, investigator-masked, prospective, noninferiority, clinical study, patients undergoing LASIK surgery were randomized to receive Hylabak or Systane eye drops (one drop in each eye four times daily for 3 months). Fluorescein test scores were the primary efficacy variable and were similar on day 1 (mean 0.26 and 0.28 for Hylabak and Systane, respectively). At the final visit (day 84 ± 3) the fluorescein scores had improved to 0.11 and 0.04, respectively. The difference was not significant and thus noninferiority was established. A trend of more rapid improvement in the Hylabak group was evident. Both treatments were well tolerated and there were no serious adverse events, discontinuations for adverse events or other safety-related reasons, and no systemic adverse events. The results suggest that Hylabak is not less effective than Systane in reducing the symptoms of dry eye after LASIK surgery.

Management of post-LASIK dry eye: a multicenter randomized comparison of a new multi-ingredient artificial tear to carboxymethylcellulose

“…Artificial tear formulations consisting of CMC or HA alone have been shown to be effective in reducing signs and symptoms of post-LASIK dry eye. 6 – 8 A combination of diquafosol tetrasodium and HA has also been reported to potentially benefit vision and improve dry eye symptoms after LASIK. 35 The benefit of osmoprotectants in lubricant drops used to treat dry eye post-LASIK has also been demonstrated, with a significant improvement in symptoms reported following treatment with HA and adjuvant trehalose compared with HA alone.…”

“…7 A preservative-free hyaluronic acid (HA) 0.15% eye drop (Hylabak ® or Hyabak ® , Thea Pharmaceuticals, Clermond-Ferrand, France) has also been shown to effectively reduce signs of dry eye post-LASIK. 8 With its intrinsic properties of water retention, viscoelasticity, and promotion of corneal epithelial wound healing, 9 HA increases viscosity, and hydrates and lubricates the ocular surface.…”

<p>The use of preservatives in dry eye drops</p>

“…The tolerability of a preservative-free dry eye drop (Hylabak ® , Laboratoires Théa, Clermont Ferrand, France) was compared to a PQ-1-preserved drop (Systane ® , Alcon Inc., Fort Worth TX) in patients for a period of three months post LASIK surgery. As assessed by the primary outcome measure of fluorescein test score, there was no significant difference between the drops, with both being well tolerated, with no serious adverse events 122…”

Experience in Gilan Comfort eye drops use of in patients after excimer laser surgery

“…Так как LASIK является эффективной процедурой, используемой для коррекции мио-ОФТАЛЬМОФАРМАКОЛОГИЯ / OPHTHALMOPHARMACOLOGY пии, гиперметропии и астигматизма, с каждым годом всё больше пациентов во всём мире пере-носят данную операцию. Как правило, ослож-нения встречаются редко, но ССГ развивает-ся практически у всех пациентов после LASIK [3,10]. У большинства пациентов ССГ, возника-ющий после операции, вызывает много жалоб, хотя и временных.…”

“…У большинства пациентов ССГ, возника-ющий после операции, вызывает много жалоб, хотя и временных. Поэтому целесообразно обя-зательное включение в схему послеоперацион-ного лечения, кроме противовоспалительных ка-пель и местного назначения антибиотиков, ещё и увлажняющих глазных капель на длительное время [3].…”