Assessment of cytogenic damage in chronic periodontitis and type 2 diabetes mellitus subjects through micronucleus test

Rathod, Surekha; Raj, Anubha; Jadhav, Padmaja; Sarda, Trupti

doi:10.4103/1658-6816.188075

Cited by 3 publications

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“…Periodontal disease is an inflammatory process involving a set of changes that directly affect tissues that hold the teeth. There are few studies that assessed the occurrence of genetic damage associated with periodontal disease 6,[20][21][22][23][24][25][26] . Genotoxic damage of periodontal disease was followed by the micronucleus assay in peripheral lymphocytes 21,24, gingival 6,20 and buccal cells 22,26 , and by sister chromatid exchange method in peripheral blood lymphocytes 25 .…”

Section: Fig 1 Multiple Regression Analysis Resultsmentioning

confidence: 99%

“…There are few studies that assessed the occurrence of genetic damage associated with periodontal disease 6,[20][21][22][23][24][25][26] . Genotoxic damage of periodontal disease was followed by the micronucleus assay in peripheral lymphocytes 21,24, gingival 6,20 and buccal cells 22,26 , and by sister chromatid exchange method in peripheral blood lymphocytes 25 .…”

Section: Fig 1 Multiple Regression Analysis Resultsmentioning

confidence: 99%

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Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

Tadin

Gavić

Roguljić

et al. 2021

ACC

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Section: Fig 1 Multiple Regression Analysis Resultsmentioning

confidence: 99%

Section: Fig 1 Multiple Regression Analysis Resultsmentioning

confidence: 99%

Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

Tadin

Gavić

Roguljić

et al. 2021

ACC

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“…First, elimination of carbohydrate by the flow of saliva which could be metabolized by bacteria and hence the acid produced by the bacteria is removed and secondly, saliva has a buffering activity which can neutralize the acidity formed from foods and drinks as well as from the microbial activity. (('Expression of VEGF in Periodontal Tissues of Type II Diabetes Mellitus Patients with Chronic Periodontitis -an Immunohistochemical Study', 2014; Rathod et al, 2016). In the present study, unstimulated saliva samples were collected from normal healthy patients and diabetic patients with periodontitis and without periodontitis as the pH may alter in stimulated salivary samples for determining salivary pH.…”

Section: Discussionmentioning

confidence: 96%

A COMPARATIVE STUDY ON SALIVARY pH IN DIABETIC PATIENTS WITH PERIODONTITIS AND WITHOUT PERIODONTITIS

2022

pnr

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Introduction: Diabetes mellitus is a common chronic disease that has emerged as a major health-care problem currently Diabetes mellitus affects 240 million people worldwide.Periodontal infections are persistent, gram-negative infections that damage not just the tissues around the tooth but also pose a systematic threat to immunocompetent cells and cells involved in the inflammatory cascade. Aim: The study aims to assess the comparison on salivary pH in diabetic patients with periodontitis and without periodontitis Materials and methods: The participants were explained about the procedure and were able to sign on the informed consent. 5 saliva samples were collected from patients with diabetes and periodontitis and 5 samples were collected from patients with diabetes and without periodontitis. The samples were collected in an Eppendorf tube passively. The samples were stored in -20 until needed. Statistics statistical analysis was performed using the SPSS (IBM SPSS Statistics for Windows, version 23.0, Armonk, NY: IBM Corp.Released 2015). The one-way ANOVA with the Tukey HSD post hoc test was used. The test was done to compare the groups and p>0.05 was considered significant. Results:The salivary pH values of subjects in group 1 ranged from 7.0 to 7.5 with a mean of 7.3±0.08. Similarly, salivary pH values of subjects in group 2 ranged from 5.5 to 7.0 with a mean of 6.0±0.43, and salivary pH values of subjects in group 3 ranged from 6.5 to 7.5 with a mean of 6.9±0.27 . The difference in mean ph value between group 1, group 2, group 3 was highly significant (p>0.05) Conclusion: The present study concludes that diabetic patients with periodontitis have reduced pH when compared to patients without periodontitis. Diabetic Mellitus has been consistently documented to be associated with altered salivary composition and function which disrupts the homeostasis of the oral cavity. This predisposes them to various oral ailments including dental caries and periodontitis.

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Nuclear morphological changes in gingival epithelial cells of patients with periodontitis

et al. 2019

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Assessment of cytogenic damage in chronic periodontitis and type 2 diabetes mellitus subjects through micronucleus test

Cited by 3 publications

References 0 publications

Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

Assessment of Cytogenetic Damage to Exfoliated Gingival Cells in Patients with Chronic Generalized Periodontitis

A COMPARATIVE STUDY ON SALIVARY pH IN DIABETIC PATIENTS WITH PERIODONTITIS AND WITHOUT PERIODONTITIS

Nuclear morphological changes in gingival epithelial cells of patients with periodontitis

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