Assessment of Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, and Pb Concentrations in Gluten-free Foods From Saudi Arabia by Inductively Coupled Plasma Mass Spectrometry

Mehder, A.O.; Soylak, Mustafa

doi:10.46770/as.2015.06.003

Cited by 11 publications

(1 citation statement)

References 27 publications

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“…The toxicological aspect of drugs is also important because of the elemental impurities they contain as well as the benefits it provide to the living metabolism. For this reason, various analytical methods such as inductively coupled plasma-optical emission spectroscopy (ICP-OES) [9][10][11][12][13], inductively coupled plasma-mass spectroscopy (ICP-MS) [14][15][16][17][18][19][20], atomic absorption spectroscopy (AAS) [21,22], graphite furnace atomic absorption spectroscopy (GFAAS) [23] and flame atomic absorption spectroscopy (FAAS) [24], which are extremely important in the determination of elemental impurities in drugs, have been developed. When these analytical methods in the literature are examined from a scientific point of view, ICP-MS and microwave-assisted digestion, which is one of the sample pre-processing methods, come to the fore when compared to other methods mentioned.…”

Section: Introductionmentioning

confidence: 99%

Oral Yol ile Alınan Alerji ve Kanser İlaçlarında Ağır Metallerin Tayini için Mikrodalga Çözünürleştirme Sistemi ile ICP-MS Analizi ve Validasyonu

KÖSE,

DALMAZ,

SİVRİKAYA ÖZAK

2023

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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The drug, one of the most important products that cannot be replaced in the field of health, prevents all threats to human health when used in place and dosage. Therefore, it has an important place in public health. Determination of the amounts and impurities of various elements used in drug production is an important parameter. According to the ICH Q3D(R1) international compliance conference guide, methods by which limit concentrations can be determined for elemental impurities by applying inductively coupled plasma (ICP) analysis to drugs are specified. In this study, the sample preparation step in the analysis of 23 elements in cancer and allergy drugs in tablet form was optimized by microwave digestion, and method development and validation studies were carried out for these drugs with inductively coupled plasma-mass spectrometry (ICP-MS). When the analysis results were evaluated, it was seen that the data obtained were by the limit values specified in the ICH. Detection and quantification limits of the developed method, and relative standard deviation values were determined, and recovery studies were carried out by adding standards at 4 different concentrations to determine the method's precision. The correlation coefficients obtained for heavy metals in this study ranged from 0.9993 to 1.000, while the detection limit was found to be between 0.001 and 1.756 µg/L. Thus, the reliability and precision of the validation study developed has been determined and it has been shown that this method can be used in similar drug samples.

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Section: Introductionmentioning

confidence: 99%

Oral Yol ile Alınan Alerji ve Kanser İlaçlarında Ağır Metallerin Tayini için Mikrodalga Çözünürleştirme Sistemi ile ICP-MS Analizi ve Validasyonu

KÖSE,

DALMAZ,

SİVRİKAYA ÖZAK

2023

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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Deciphering of Ligand‐to‐Metal Charge‐Transfer Process: Synthesis, Spectroscopic and Theoretical Study

et al. 2019

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Many reports on metal ion sensing applications are available in literature but the mechanism of selectivity is not clear. Here the synthesis and characterization of a Schiff base Furan‐2‐carboxylic acid pyren‐1‐ylmethylene‐hydrazide (PYFH) has been described with selective detection of copper(II) metal ion among different metal ions by UV–vis, fluorescence and HRMS spectroscopic methods. The S2− ion (Na2S) was added to the PYFH:Cu2+ complex for checking reversibility of PYFH by fluorescence, fluorescence microscopic imaging and molecular logic gate construction (combination of NOT and OR gate). From the experimental findings the reason for selectivity of Cu2+ metal ion among a series of metal ions is not clear. So, to explore the causes of selectivity of Cu2+ metal ion by PYFH, Density Functional Theory (DFT) calculation was conducted for free PYFH and various sets of metal ions individually with PYFH. From DFT calculation it was understandable that selectivity of PYFH towards Cu2+ ions occurred due to lowering of HOMO‐LUMO energy of PYFH:Cu2+ composites (‐8.46 & −5.80 eV) compared to free PYFH (‐5.56 & −2.15 eV). Whereas energy of HOMO and LUMO with other metals ions (PYFH:Mn+) are ∼‐5.50 and ∼‐2.24 eV respectively, as a result PYFH does not get any extra stability.

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Investigation of Trace Elements in Vegan Foods by ICP-MS After Microwave Digestion

Köprü

Çadır

Soylak

2022

Biol Trace Elem Res

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Assessment of Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, and Pb Concentrations in Gluten-free Foods From Saudi Arabia by Inductively Coupled Plasma Mass Spectrometry

Cited by 11 publications

References 27 publications

Oral Yol ile Alınan Alerji ve Kanser İlaçlarında Ağır Metallerin Tayini için Mikrodalga Çözünürleştirme Sistemi ile ICP-MS Analizi ve Validasyonu

Oral Yol ile Alınan Alerji ve Kanser İlaçlarında Ağır Metallerin Tayini için Mikrodalga Çözünürleştirme Sistemi ile ICP-MS Analizi ve Validasyonu

Deciphering of Ligand‐to‐Metal Charge‐Transfer Process: Synthesis, Spectroscopic and Theoretical Study

Investigation of Trace Elements in Vegan Foods by ICP-MS After Microwave Digestion

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