Assessment of coupled Zn concentration and natural stable isotope analyses of urine as a novel probe of Zn status

Moore, Rebekah E. T.; Rehkämper, Mark; Maret, Wolfgang; Larner, Fiona

doi:10.1039/c9mt00160c

Cited by 12 publications

(6 citation statements)

References 74 publications

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“…We report urine Zn concentration data adjusted for hydration status using the specific gravity (sg) method, as in Phiri et al (2020) where sg was a suitable adjustment method for urine Se concentration for both WRA and SAC. Other studies have also used sg to adjust urine Zn concentration (Moore et al 2017(Moore et al , 2019Middleton et al 2019). The sg was measured using a handheld temperature-corrected refractometer (PAL-10S, Atago, Japan), on 1 to 2 drops of urine.…”

Section: Specific Gravity Adjustment For Hydration Statusmentioning

confidence: 99%

Spatial analysis of urine zinc (Zn) concentration for women of reproductive age and school age children in Malawi

Phiri

Ander

Lark

et al. 2020

Environ Geochem Health

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Zinc (Zn) is an essential micronutrient, and Zn deficiency remains a major global public health challenge. Recognised biomarkers of population Zn status include blood plasma or serum Zn concentration and proxy data such as dietary Zn intake and prevalence of stunting. Urine Zn concentration is rarely used to assess population Zn status. This study assessed the value of urine Zn concentration as a biomarker of population Zn status using a nationally representative sample of non-pregnant women of reproductive age (WRA) and school-aged children (SAC) in Malawi. Spot (casual) urine samples were collected from 741 WRA and 665 SAC. Urine Zn concentration was measured by inductively coupled plasma mass spectrometry with specific gravity adjustment for hydration status. Data were analysed using a linear mixed model with a spatially correlated random effect for between-cluster variation. The effect of time of sample collection (morning or afternoon), and gender (for SAC), on urine Zn concentration were examined. There was spatial dependence in urine Zn concentration between clusters among SAC but not WRA, which indicates that food system or environmental factors can influence Electronic supplementary material The online version of this article (

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Section: Specific Gravity Adjustment For Hydration Statusmentioning

confidence: 99%

Spatial analysis of urine zinc (Zn) concentration for women of reproductive age and school age children in Malawi

Phiri

Ander

Lark

et al. 2020

Environ Geochem Health

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“…Zinc isotopes are also fractionated between the organs of animals [37,38]. In humans, the blood and urine Zn isotopic composition have been suggested to reveal dietary habits [39] and more genrally, the Zn status in human [40]. The blood Zn isotopic composition has been shown to become heavier during ageing in a remote human Yakut population [25], but experiments on a worm model [26] and on a rodent model [41] did not confirm this finding.…”

Section: Introductionmentioning

confidence: 99%

Inter-comparison of stable iron, copper and zinc isotopic compositions in six reference materials of biological origin

Sauzéat

Costas‐Rodríguez

Albalat

et al. 2021

Talanta

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There is a lack of certified reference materials with an organic matrix for which metal isotope ratios have been certified. Here, we have determined the iron, copper and zinc stable isotopic compositions for six reference materials of biological origin with diverse matrices, i.e. BCR-380R (whole milk), BCR-383 (beans), ERM-CE464 (tuna fish), SRM-1577c (bovine liver), DORM-4 (fish protein) and TORT-3 (lobster hepatopancreas) in three different labs. The concentrations for six major and sixteen trace elements, spanning almost four orders of magnitude, were also measured and the results obtained show an excellent agreement with certified values, demonstrating that the dissolution step was quantitative for all the standards. By taking literature data into account, 39 possible pair-wise comparisons of mean iron, copper and zinc isotopic values (δ values) could be made. Results of Tukey multiple comparisons of means yielded 11 significantly different pairs. Most of these differences are of the same order of magnitude as the estimated mean expanded uncertainties (U, k = 2) (±0.10‰, ±0.05‰, and ±0.05‰ for the δ 56 Fe, δ 65 Cu and δ 66 Zn values, respectively). The present intercomparison study finally proposes nineteen new preferred values for the Cu, Zn and Fe isotopic compositions of six reference materials of biological origin.

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“…This may explain the enrichment of heavier Sb in urine. In addition, according to a study of Zn isotopes, 54 the difference between the isotope compositions of blood and urine may be due to the fact that low molecular weight molecules-Sb with a preferential enrichment of the light Sb isotope is filtered by the glomerulus during urination, resulting in heavier Sb isotopic composition in urine. Further studies on the mechanisms of adsorption/desorption, redox, methylation and human physiology are needed to verify these hypotheses.…”

Section: Resultsmentioning

confidence: 99%

Sampling and determination of antimony isotopes in airborne particles: an assessment of membrane filter materials

Zhang

Sun

et al. 2022

J. Anal. At. Spectrom.

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Assessment of coupled Zn concentration and natural stable isotope analyses of urine as a novel probe of Zn status

Abstract: Heavier Zn isotope compositions in urine compared to blood serum and an accompanying isotope-concentration trend likely reflects Zn processing in the kidneys in response to bodily Zn requirements.

Cited by 12 publications

References 74 publications

Spatial analysis of urine zinc (Zn) concentration for women of reproductive age and school age children in Malawi

Spatial analysis of urine zinc (Zn) concentration for women of reproductive age and school age children in Malawi

Inter-comparison of stable iron, copper and zinc isotopic compositions in six reference materials of biological origin

Sampling and determination of antimony isotopes in airborne particles: an assessment of membrane filter materials

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