Assessment of Cortical Sulci Formations and Diagnosis of Lissencephaly in Three Dogs Using Transcranial Ultrasound

Lissencephaly in an adult Australian Kelpie

“…Recently, the use of transcranial ultrasound for investigation of central neurological conditions and for the assessment of cortical sulci formation in dogs has been described . Using this technique, 4 of 55 (7.3%) dogs with neurological signs were identified to have an absence of gyri and therefore suspected to be lissencephalic .…”

“…18 Recently, the use of transcranial ultrasound for investigation of central neurological conditions and for the assessment of cortical sulci formation in dogs has been described. 19,20 Using this technique, 4 of 55 (7.3%) dogs with neurological signs were identified to have an absence of gyri and therefore suspected to be lissencephalic. 19 Although the diagnosis was not confirmed with MRI or at postmortem, electroencephalography was performed and rhythm asynchrony between symmetric leads was reported.…”

“…That was consistent with findings reported by Greene et al in two dogs with lissencephaly. In a second study, 3 of 104 (2.9%) dogs were identified to be lissencephalic, two of which were confirmed at postmortem and one with MRI . With the increasing availability of MRI and the potential use of transcranial ultrasound, the diagnosis of lissencephaly may become more frequent.…”