Assessment of correlations between sildenafil use and comorbidities and lifestyle factors using wastewater-based epidemiology

Shao, Xianzhao; Zhang, Pei-Yao; Liu, Siyu; Lin, Johnson; Tan, Dali; Wang, Degao

doi:10.1016/j.watres.2022.118446

Cited by 10 publications

(3 citation statements)

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“…The detection frequency of oxypurinol and febuxostat in wastewater was 100%, while benzbromarone and colchicine were not detected at the sampling sites. The concentration of oxypurinol (59.2 μg/L) was much higher than that of febuxostat (4.05 ng/L) in this study . The mean value of oxypurinol was similar to that in Australia (51.1 μg/L in 2019) …”

Section: Resultssupporting

confidence: 56%

“…Unhealthy lifestyles, an aging population, economic development, and medical level are linked to the prevalence of disease in communities. Information on the lifestyle of the population, such as smoking and alcohol consumption, can be obtained by WBE. − In this study, alcohol and nicotine values in the same WWTPs were obtained from Shao et al (2021 and 2022). , Correlation analysis found that nicotine consumption was positively correlated with hydrochlorothiazide use ( r = 0.36; p < 0.05), and alcohol consumption was positively correlated with metformin ( r = 0.42; p < 0.05), allopurinol ( r = 0.65; p < 0.05), and hydrochlorothiazide ( r = 0.46; p < 0.05) use, indicating that nicotine and alcohol consumption would increase the prevalence of disease, which has been confirmed by some epidemiological studies. − In addition, it was found that metformin use was positively associated with allopurinol, caffeine, and venlafaxine use in Australia …”

Section: Resultsmentioning

confidence: 87%

“…The concentration of oxypurinol (59.2 μg/L) was much higher than that of febuxostat (4.05 ng/L) in this study. 41 The mean value of oxypurinol was similar to that in Australia (51.1 μg/L in 2019). 28 3.2.…”

Section: Concentrations Of Biomarkers 311 Hypertensionmentioning

confidence: 99%

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Evaluation of Three Chronic Diseases by Selected Biomarkers in Wastewater

et al. 2023

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Wastewater-based epidemiology has some advantages in assessing chronic diseases with high prevalence, but selecting appropriate biomarkers is difficult. The aim of this study was to screen biomarkers in wastewater to accurately assess the prevalence of hypertension (ten drugs), diabetes (eight drugs), and gout (four drugs). The concentrations of biomarkers in the influent from 37 wastewater treatment plants in 34 Chinese cities were assessed using LC/MS−MS combined with solid-phase extraction. Biomarkers with excretion rates above 5% and high stability (>80%) and detection frequency (>80%) were selected to evaluate the prevalence. Sartans, hydrochlorothiazide, sotalol, and nornifedipine have been identified as biomarkers for hypertension; metformin and glibenclamide for diabetes; and oxypurinol and febuxostat for gout. The prevalence rates of hypertension, diabetes, and gout in China assessed using these biomarkers were 26% (95CI %: 18.8−36.5), 9.58% (95CI %: 6.62−14.2), and 5.95% (95CI %: 4.22−6.74), respectively, which were consistent with government survey data. We found a cooccurrence of hypertension, diabetes, and gout prevalence, and they were associated with unhealthy lifestyle, economics, and medical level. The results suggested that wastewater-based epidemiology is an effective approach to accurately assess disease prevalence by selecting multiple biomarkers, providing valuable information for public health.

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Section: Resultssupporting

confidence: 56%