Assessment of circulating FCεRIa in Chronic Spontaneous Urticaria patients and its correlation with clinical and immunological variables

Baioumy, Shereen A.; Esawy, Marwa M.; Shabana, Marwa A.

doi:10.1016/j.imbio.2018.08.009

Cited by 13 publications

(16 citation statements)

References 36 publications

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“…Generally, a positive reaction indicates the presence of IgG antibodies against either the high-affinity IgE receptor (FcεRI) on both mast cells and basophils (in most cases) or membrane-bound IgE (in a minority of patients), with the capacity of inducing basophils or mast cells activation and mediator release. In agreement with a recent Egyptian evaluation and a revision on the pathogenesis of CSU, we found that ASST was positive only in about half of the patients evaluated, despite its severity or length of disease 15, 16. Not only IgG but also IgE autoantibodies could play a hypothetical role both in the etiology and in pathogenesis of CSU in a subset of patients, such as those having autoimmune thyroid disease, a situation that besides its autoimmune nature, has been termed as “auto-allergic” 15, 17, 18.…”

Section: Discussionsupporting

confidence: 91%

Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region

Gómez

Járes

Borges

et al. 2019

World Allergy Organization Journal

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Chronic urticaria (CU) has a widespread spectrum on causal or exacerbating factors, clinical manifestations, therapeutic response and quality of life affectation. Registries are useful tools in several real-life diagnosis and management approach. We aimed to evaluate the characteristics of CU patients living in Latin America through an original cross-sectional registry with data entered by regional allergologists. Results Three hundred patients were included, being 72% female, with median age of 36 years (1–85) and 20 months of CU median evolution time. The cause of CU was reported as unknown in 72% of them. Thirty-nine percent of suspected cases presented positive serology for Mycoplasma, positive autologous serum skin test (ASST) was reported in 47%, and occasional presence of thyroid or antinuclear autoantibodies and parasites. The impact of pruritus in their quality of life was moderate to severe in 60% of patients, with almost 3 out of four patients having partial or lack of urticaria control with anti-histamines. Conclusions Our registry provides retrospective data on the real-life assistance of a large number of patients from the region. Continuous search for associated conditions and better treatment possibilities are needed, in order to control the significant impact on quality of life and the length of disease.

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Section: Discussionsupporting

confidence: 91%

Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region

Gómez

Járes

Borges

et al. 2019

World Allergy Organization Journal

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“…This finding is somewhat contradictory those of other groups, who reported up to sixfold higher rates of IgG autoantibodies to FcɛRIαin ASSTpositive patients compared to ASST-negative CSU patients. 29,33 However, our cohort had overall small numbers, especially in the ASST-negative CSU patient group, which limits the interpretation of our results. Furthermore, other studies used different methods for FcɛRIα is not only expressed on mast cells, but also on basophils 39 and in some inflammatory diseases, also on eosinophils.…”

Section: In Patients With Csu Igm Against Fcɛriα But Not Igg or Imentioning

confidence: 84%

“…18,19,[29][30][31][32][33] More interestingly, the majority of our analyzed sera also con- The ASST is a well-established test to investigate serum autoreactivity in patients with CSU 35 and has been associated with IgG antibodies against the FcɛRIα or against IgE (Type IIb autoimmunity). 7,33 Also, basophil activation tests and basophil histamine release tests have been shown to be a good surrogate marker for autoimmunity in CSU, 7 but are not commonly available as routine analysis and had not been assessed in this study cohort. Surprisingly, in our cohort, ASST-positive patients did not show a higher rate of elevated levels of IgG to FcɛRIα compared with ASST-negative patients.…”

Section: In Patients With Csu Igm Against Fcɛriα But Not Igg or Imentioning

confidence: 85%

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IgM and IgA in addition to IgG autoantibodies against FcɛRIα are frequent and associated with disease markers of chronic spontaneous urticaria

Altrichter

Zampeli

Ellrich

et al. 2020

Allergy

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Background: IgG autoantibodies against the high-affinity IgE receptor, FcɛRIα, contribute the pathogenesis of autoimmune chronic spontaneous urticaria (CSU). However, it is not known whether such patients also exhibit IgM or IgA autoantibodies against FcɛRIα. To address this question we developed an ELISA to assess serum levels of IgG, IgM, and IgA autoantibodies against FcɛRIα and investigated whether their presence is linked to clinical features of CSU including the response to autologous serum skin testing (ASST). Methods: Serum samples of 35 CSU patients (25 ASST-positive) and 52 healthy control individuals were analyzed using a newly developed competitive ELISA for IgG, IgM, and IgA autoantibodies to FcɛRIα. Results: One in four CSU patients (8/35, 24%) had elevated serum levels of IgGanti-FcɛRIα compared with (3/52, 6%) healthy controls. More than half of patients had IgM (21/35, 60%) and IgA (20/35, 57%) vs (3/52, 5%) each in healthy controls. Elevated IgM, but not IgG or IgA, autoantibodies were significantly more frequent in ASST-positive CSU patients (18/25, 72%) compared with ASSTnegative patients

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“…Case control studies indicate that total IgE levels are higher in CSU patients as compared with healthy individuals. [12][13][14][15][16] On the other hand, total IgE levels in patients with CSU are not so high as in patients with allergies or atopic diseases. In atopic dermatitis, for example, IgE levels often reach 1,000 IU/mL or more.…”

Section: Are Total Serum Ige Levels Elevated In Csu?mentioning

confidence: 99%

Total IgE as a Marker for Chronic Spontaneous Urticaria

Altrichter

Fok

Jiao

et al. 2021

Allergy Asthma Immunol Res

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Objective: Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and responses to treatment. The evidence in support of total IgE included in the diagnostic workup of patients with CSU has not yet been reviewed. Methods: Publications were searched via PubMed. The search terms used were "chronic urticaria" and "total IgE." Studies were screened by titles and abstracts, and 141 were used in the review. Results: CSU patients frequently had elevated total IgE serum levels (up to 50%), but normal or very low total IgE levels also occurred. High total IgE may represent high disease activity, longer disease duration, high chance of responding to omalizumab treatment, quick relapse after stopping omalizumab, and lower chance of responding to cyclosporine. Low IgE, in contrast, may suggest Type IIb autoimmune CSU, poor response to treatment with omalizumab and a better chance to benefits from cyclosporine treatment. Furthermore, IgE in different CSU cohorts may have different physicochemical properties that could explain differences in treatment responses to IgE-directed therapies. Conclusion: The results of our review suggest that total IgE is a valuable marker for CSU, and we recommend its assessment in the routine diagnostic workup of CSU patients.

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Assessment of circulating FCεRIa in Chronic Spontaneous Urticaria patients and its correlation with clinical and immunological variables

Cited by 13 publications

References 36 publications

Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region

Latin American chronic urticaria registry (CUR) contribution to the understanding and knowledge of the disease in the region

IgM and IgA in addition to IgG autoantibodies against FcɛRIα are frequent and associated with disease markers of chronic spontaneous urticaria

Total IgE as a Marker for Chronic Spontaneous Urticaria

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