Assessment of chemotherapy on various biochemical markers in breast cancer patients

Abstract

Chemotherapy is a standard treatment method for the patients with locally advanced breast cancer. Lately, cyclophosphamide (CYP) and doxorubicin (DOX) are used as the major chemotherapeutic agents especially for the treatment of breast cancer. Till date, no serum biomarker has been able to provide an early diagnosis of breast cancer. This study aimed to assess inflammatory, cardiac, renal and hematological markers in 56 breast cancer patients (BCP) before, during and after termination of chemotherapy with CYP and DOX. Blood samples were collected from the patients at the each treatment stages mentioned above. These samples were assessed for interleukin 6 (IL-6), interleukin 10 (IL-10), lactate dehydrogenase (LDH), creatine kinase (CK), creatinine, hemoglobin (Hb), leukocyte, platelet and Na /K -ATPase levels either by ELISA or colorimetric methods. The results suggest a significant increase in IL-6 level at all the stages in BCP as compared to control group. On the other hand, IL-10, CK and Na /K -ATPase levels were found to be significantly declined during all the stages. Moreover, the majority of hematological parameters remained unchanged throughout the treatment period with the exception of creatinine and Hb which showed slight modulation in their level at different stages. Based on the results, we conclude that breast cancer and co-treatment with CYP and DOX, interfere arious biological markers, thereby, showing the physiological imbalance.

Low Sucrose, Omega-3 Enriched Diet Has Region-Specific Effects on Neuroinflammation and Synaptic Function Markers in a Mouse Model of Doxorubicin-Based Chemotherapy

“…By day 14, the mean for the chemotherapy group was significantly higher than the vehicle group ( p < 0.05). IL-6 was significantly higher among the chemotherapy than vehicle groups at all time points (Figure 1D; p < 0.0001), suggesting a sustained effect of chemotherapy on this cytokine, as has been noted in breast cancer patients undergoing doxorubicin plus cyclophosphamide treatment [31]. Altogether, these findings suggest that chemotherapy leads to systemic inflammation, an effect that can be partly moderated by n-3 PUFAs.…”

Hematological and biochemical parameters for Chinese rhesus macaque

“…Hematological and biochemical parameters are important indicators in biology and medical research. They are used to judge the health status of animals and thus provide important references in the study of pathology and toxicology and directly and indirectly reflect organ functions [21, 27, 52]. In recent years, as an important animal model, Chinese rhesus macaques have been increasingly used for biomedical research, including disease development, establishment of transgenic animals and stem cells, construction of animal models of diseases, and pre-clinical investigations [53–56].…”

Effect of chemotherapy and aromatase inhibitors in the adjuvant treatment of breast cancer on glucose and insulin metabolism—A systematic review

“…Low levels of adiponectin have been linked to increased BC mortality. 40 Interleukins has been shown by Paz et al 41 to be affected by chemotherapy, as they found that despite IL-6 being increased and IL-10 being decreased compared to controls before treatment; chemotherapy further enhanced this tendency. Another study found no change in interleukins, including IL-6, during adjuvant chemotherapy and/or treatment with aromatase inhibitors.…”