Hematological and biochemical parameters for Chinese rhesus macaque

Abstract

Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.

Retrospective Evaluation of a Minor Dietary Change in Non-Diabetic Group-Housed Long-Tailed Macaques (Macaca fascicularis)

“…In the present study, higher triglyceride levels were found in older individuals compared to younger monkeys both before and after the dietary change. Similar age-effects have been reported in other studies with both long-tailed macaques and rhesus macaques [ 42 , 43 , 59 , 60 ]. Possibly, no significant effect of dietary change on triglyceride levels was found because the effect of dietary change was counteracted by an age-effect.…”

Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques

“…5 E– 5 K), indicating that 25HC will not cause additional toxicity to the kidney and heart. Compared to the ART-only group, the ratio of AST/ALT in RMs of 25HC+ART group was within the normal range (Yu et al 2019 ), although there was a higher concentration of aspartate aminotransferase (AST) in the 25HC+ART group (Fig. 5 F), suggesting that 25HC will not cause additional toxicity to liver.…”

Blood Analysis of LaboratoryMacaca mulattaUsed for Neuroscience Research: Investigation of Long-Term and Cumulative Effects of Implants, Fluid Control, and Laboratory Procedures

“…H , Comparison of red blood cell counts to corresponding reports from the literature. Labeling of x -axis (SC68, …, KL19) refers to Stanley and Cramer (1968) , Rosenblum and Coulston (1981) , Kessler and Rawlins (1983) , Bennett et al (1992) , Fernie et al (1994) , Buchl and Howard (1997) , Hom et al (1999) , Smucny et al (2001) , Andrade et al (2004) , Chen et al (2009) , Didier et al (2012) , Koo et al (2019) , and Yu et al (2019) , in that order. “Own” refers to data from present study, as shown in G .…”

“…For testing effects over the entirety of blood values, false positives were controlled by setting the FDR criterion to α = 0.1. Literature values for comparison were obtained from Stanley and Cramer (1968) , Rosenblum and Coulston (1981) , Kessler and Rawlins (1983) , Bennett et al (1992) , Fernie et al (1994) , Buchl and Howard (1997) , Hom et al (1999) , Smucny et al (2001) , Andrade et al (2004) , Chen et al (2009) , Didier et al (2012) , Koo et al (2019) , and Yu et al (2019) . If a given paper reported blood values separately for male and female animals, we only considered males.…”