Assessment of cellular and humoral immunity of myasthenics.

Huang, Shih Wen; Rose, John; Mayer, Richard F.

doi:10.1136/jnnp.40.11.1053

Cited by 20 publications

(6 citation statements)

References 42 publications

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“…We could not demonstrate thymocyte staining, although other authors have described antibodies to the thymocyte membrane in MG sera (24,25). Nor were lhe antibodies to the myoid cells absorbed with thymocytes in our study.…”

Section: Discussioncontrasting

confidence: 84%

Myasthenia gravis: the specificities of skeletal muscle and thymus antibodies

Gilhus

Aarli

Matre

1983

Acta Neurologica Scandinavica

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Antibodies against skeletal muscle antigens and against thymic myoid cells were examined in sera from 40 patients with myasthenia gravis (MG). Using an indirect immunofluorescence technique, antibodies against the surface of muscle cells were found in 23 sera, and antibodies against muscle cell cross-striations in 28 sera. Antibodies against thymic myoid cells were found in 27 sera, stained cells also occurring in fetal thymus from 14 weeks of gestation and in hyperplastic thymus from MG patients. Sera which stained myoid cells also stained muscle cell cross-striations. Sera from all the 20 patients with thymoma contained antibodies to a citric acid extract of skeletal muscle (CAE) as detected by indirect haemagglutination, whereas sera from 20 comparable patients without thymoma did not contain CAE antibodies. The myoid cell antibodies could be absorbed by homogenized muscle, but not by CAE-coated sheep erythrocytes. Different antibody patterns are seen among different MG patients; close associations were found between cross-striational and myoid cell antibodies, and between CAE-antibodies and a thymoma.

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Section: Discussioncontrasting

confidence: 84%

Myasthenia gravis: the specificities of skeletal muscle and thymus antibodies

Gilhus

Aarli

Matre

1983

Acta Neurologica Scandinavica

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“…Some investigators have found depressed responses to phytomitogens in non-thymectomized MG patients [41,45,105] whereas others [30,40,97] including ourselves [63] did not confirm this abnormality. The response to standard mitogens has been tested using indirect macrophage migration [9] and indirect leukocyte migration inhibition [35].…”

Section: Cell-mediated Immunity (Cmi)mentioning

confidence: 76%

Phenotypic and functional analysis of lymphocytes in myasthenia gravis

Levinson

Lisak

Zweiman

et al. 1985

Springer Semin Immunopathol

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“…T cells and B cells, as part of the acquired arm of immunity, have long been known as key inducers of a variety of autoimmune diseases. T cells and B cells have been implicated in uveitis, hemolytic anemia, colitis, myasthenia gravis, lupus, and rheumatoid arthritis among other diseases (7)(8)(9)(10)(11)(12). NK cells, being part of the innate immune system, have been implicated in such autoimmune diseases as diabetes and insulitis, as well as rheumatoid arthritis (13)(14)(15).…”

mentioning

confidence: 99%

In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses

Winkler‐Pickett

Young

Cherry³

et al. 2008

The Journal of Immunology

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Innate immune responses provide the host with its first line of defense against infections. Signals generated by subsets of lymphocytes, including NK cells, NKT cells, and APC during this early host response determine the nature of downstream adaptive immune responses. In the present study, we have examined the role of innate NK cells in an autoimmune model through the use of primary immunization with the myelin oligodendrocyte glycoprotein peptide to induce experimental autoimmune encephalomyelitis (EAE). Our studies have shown that in vivo depletion of NK cells can affect the adaptive immune responses, because NK cells were found to regulate the degree of clinical paralysis and to alter immune adaptive responses to the myelin oligodendrocyte glycoprotein peptide. The requirement for NK cells was reflected by changes in the T cell responses and diminished clinical disease seen in mice treated with anti-NK1.1, anti-asialo GM1, and selected Ly49 subtype-depleted mice. In addition to alteration in T cell responses, the maturational status of dendritic cells in lymph nodes was altered both quantitatively and qualitatively. Finally, examination of TCR Vβ usage of the brain lymphocytes from EAE mice indicated a spectra-type change in receptor expression in NK- depleted mice as compared with non-NK-depleted EAE mice. These findings further establish a recently postulated link between NK cells and the generation of autoreactive T cells.

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Assessment of cellular and humoral immunity of myasthenics.

Cited by 20 publications

References 42 publications

Myasthenia gravis: the specificities of skeletal muscle and thymus antibodies

Myasthenia gravis: the specificities of skeletal muscle and thymus antibodies

Phenotypic and functional analysis of lymphocytes in myasthenia gravis

In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses

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