Assessment of CD200R Activation in Combination with Doxycycline in a Model of Melioidosis

Thom, Ruth; Williamson, E. Diane; Casulli, Joshua; Butcher, Wendy; Burgess, Gary; Laws, Thomas R.; Huxley, Paul; Ashfield, Rebecca; Travis, Mark A.; D’Elia, Riccardo V.

doi:10.1128/spectrum.04016-22

Microbiol Spectr

2023

DOI: 10.1128/spectrum.04016-22

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Assessment of CD200R Activation in Combination with Doxycycline in a Model of Melioidosis

Ruth Thom

E. Diane Williamson

Joshua Casulli

et al.

Abstract: Traditional treatments for infectious disease have focused on the use of antimicrobial compounds (e.g. antibiotics) that target the infecting organism. However, timely diagnosis and administration of antibiotics remain crucial to ensure efficacy of these treatments especially for the highly virulent biothreat organisms.

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2024

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Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

Barnes,

Brett,

Burtnick

et al. 2024

Infect Immun

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Melioidosis is a disease that is difficult to treat due to the causative organism, Burkholderia pseudomallei being inherently antibiotic resistant and it having the ability to invade, survive, and replicate in an intracellular environment. Combination therapy approaches are routinely being evaluated in animal models with the aim of improving the level of protection and clearance of colonizing bacteria detected. In this study, a subunit vaccine layered with the antibiotic finafloxacin was evaluated in vivo against an inhalational infection with B. pseudomallei in Balb/c mice. Groups of mice vaccinated, infected, and euthanized at antibiotic initiation had a reduced bacterial load compared to those that had not been immunized. In addition, the subunit vaccine provided a synergistic effect when it was delivered with a CpG ODN and finafloxacin was initiated at 48 h post-challenge. Vaccination was also shown to improve the outcome, in a composite measure of survival and clearance. In summary, layering a subunit vaccine with the antibiotic finafloxacin is a promising therapeutic alternative for use in the treatment of B. pseudomallei infections.

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Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

Barnes,

Brett,

Burtnick

et al. 2024

Infect Immun

View full text Add to dashboard Cite

show abstract

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Assessment of CD200R Activation in Combination with Doxycycline in a Model of Melioidosis

Cited by 1 publication

References 23 publications

Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

Layering vaccination with antibiotic therapy results in protection and clearance of Burkholderia pseudomallei in Balb/c mice

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