Layering vaccination with antibiotic therapy results in protection and clearance of
Burkholderia pseudomallei
in Balb/c mice
Kay B. Barnes,
Paul Brett,
Mary Burtnick
et al.
Abstract:Melioidosis is a disease that is difficult to treat due to the causative organism,
Burkholderia pseudomallei
being inherently antibiotic resistant and it having the ability to invade, survive, and replicate in an intracellular environment. Combination therapy approaches are routinely being evaluated in animal models with the aim of improving the level of protection and clearance of colonizing bacteria detected. In this study, a subunit vaccine layered with the antibiotic finafloxacin wa… Show more
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