Assessment of Cardiotoxic Side Effects in the Administration of Organotin Compounds at the Preclinical Stage of the Study

Metastasis is a complex multicomponent process that largely determines the effect of the tumor process on the body. The study of indicators of changes in the activity of metastasis under the influence of new antitumor agents is one of the most important tasks of experimental pharmacology and oncology. The effect of the organotin compounds (OOS) bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethylolol (Me3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenylolol (Me5) was studied at the maximum effective total doses of 375 mg/kg and 250 mg/kg, respectively, on a model of a spontaneously metastasizing transferable tumor melanoma B16. Both compounds showed a high antimeta- static effect, more pronounced for the dialkyl organic compound.

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Effect of Hybrid Organotin Compounds at the Maximum Effective Dose on the Growth and Metastasis Activity of B16 Melanoma in C57bl/6 Mice

Додохова

Котиева

Сафроненко

et al. 2022

Crimea Journal of Experimental and Clinical Medicine

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Impact of organotin compounds on the growth of epidermoid Lewis carcinoma

Додохова¹,

Сафроненко²,

Котиева³

et al. 2021

RRP

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Introduction: Search for new compounds with a broad antitumor and antimetastatic potency due to multiple targeting remains important in medicinal chemistry, pharmacology and oncology. We report the efficacy of hybrid organotin agents bis-(3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Ме3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Ме5). Materials and methods: The compounds were administered to mice bearing the spontaneously metastatic epidermoid Lewis lung carcinoma (LLC). The efficacy of the treatment was evaluated by mean life span, percentage of tumor growth inhibition, number of lung metastases, frequency of metastasis, tumor weight 21 days after tumor cell inoculation, and a degree of lung damage according to the method of D. Tarin and J.E. Price. Results and discussion: For new organotin compounds containing an antioxidant protective fragment of 2,6-di-tert-butylphenol, moderate antitumor and pronounced antimetastatic effects were revealed in the Lewis model of epidermoid lung carcinoma; more active for Me5. Some features of the development of the process of metastasis were recorded with the introduction of various doses of hybrid organotin compounds. Conclusion: Substances Ме3 and Ме5 possess specific activity on the model under investigation, which allows one to suggest these organotins as promising series of antitumor and antimetastatic agents with multiple targeting mode of action.

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Assessment of Cardiotoxic Side Effects in the Administration of Organotin Compounds at the Preclinical Stage of the Study

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Effect of Hybrid Organotin Compounds at the Maximum Effective Dose on the Growth and Metastasis Activity of B16 Melanoma in C57bl/6 Mice

Effect of Hybrid Organotin Compounds at the Maximum Effective Dose on the Growth and Metastasis Activity of B16 Melanoma in C57bl/6 Mice

Impact of organotin compounds on the growth of epidermoid Lewis carcinoma

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