Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders

Chen, Vincent Chin Hung; Shen, Chao; Liang, Sophie Hsin Yi; Li, Zhen Hui; Hsieh, Ming-Kai; Tyan, Yeu Sheng; Lu, Mong Liang; Lee, Yena; McIntyre, Roger S.; Weng, Jun

doi:10.7717/peerj.3147

Cited by 26 publications

(22 citation statements)

References 57 publications

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“…The results revealed that MSPSS scores and state anxiety scores were independently associated with fALFF activity of the amygdala with opposite effects, positively and negatively, respectively. The positive association between anxiety and the amygdala is consistent with previous findings that heightened activity in the amygdala was associated with anxiety and depression 24,47,48 as well as perceived stress level 22 . Collectively, these antagonistic relationships between perceived social support and ill-being on amygdala activity may underlie the well-validated relationship between perceived social support and ill-being, including perceived stress, anxiety, and depression 4 .…”

Section: Discussionsupporting

confidence: 91%

“…www.nature.com/scientificreports www.nature.com/scientificreports/ high anxiety and depression exhibit a lower volume and heightened resting-state activity in the amygdala 23,24 . Based on these findings, and in conjunction with ample evidence showing that people with high perceived social support generally have low levels of perceived stress or psychiatric problems 4 , we hypothesized that perceived social support would be negatively associated with fALFF values in the amygdala.…”

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confidence: 99%

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Amygdala activity related to perceived social support

Sato

Kochiyama²,

Uono

et al. 2020

Sci Rep

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Perceived social support enhances well-being and prevents stress-related ill-being. A recent structural neuroimaging study reported that the amygdala volume is positively associated with perceived social support. However, it remains unknown how neural activity in this region and functional connectivity (FC) between this and other regions are related to perceived social support. To investigate these issues, resting-state functional magnetic resonance imaging was performed to analyze the fractional amplitude of low-frequency fluctuation (fALFF). Perceived social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Lower fALFF values in the bilateral amygdalae were associated with higher MSPSS scores. Additionally, stronger FC between the left amygdala and right orbitofrontal cortex and between the left amygdala and bilateral precuneus were associated with higher MSPSS scores. The present findings suggest that reduced amygdala activity and heightened connectivity between the amygdala and other regions underlie perceived social support and its positive functions.The subjective perception of social support (i.e., the feeling of being supported by other people) plays a crucial role in human resilience and well-being. A number of psychological studies have shown that perceived social support prevents ill-being, such as perceived stress, anxiety, and depression 1-5 and enhances well-being, such as subjective happiness 6-9 . To investigate this important psychological construct, psychometric studies have developed several questionnaires, including the Multidimensional Scale of Perceived Social Support (MSPSS 10 ), that reliably and validly measure perceived social support. Subjectively perceived social support is related to received social support, but at only moderate strength, whereas it is more consistently linked to the aforementioned positive effects 11,12 . Based on these findings, it has been proposed that perceived social support is a stable characteristic, similar to a trait or a personality feature 11,13 .To explore the neural mechanisms underlying perceived social support, a recent structural neuroimaging study has investigated the regional brain volumes associated with perceived social support as measured using the MSPSS 14 . The study reported that left amygdala volume is positively associated with MSPSS scores, which indicates that the amygdala plays an important role in the implementation of perceived social support.However, the type of amygdala activity (i.e., hyper-or hypoactivity) related to perceived social support remains unknown. This information would be valuable for understanding the functional role of the amygdala in perceived social support. Several functional magnetic resonance imaging (fMRI) studies have indicated that low-frequency (<0.1 Hz) resting-state neural activity in the absence of a task is a suitable measure for assessing brain activity related to stable psychological constructs, such as perceived social support 15,16 . It has been proposed that t...

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Section: Discussionsupporting

confidence: 91%

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confidence: 99%

Amygdala activity related to perceived social support

Sato

Kochiyama²,

Uono

et al. 2020

Sci Rep

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“…Changes in the local cliques can also be affected by mood. People diagnosed as having major depressive disorders demonstrated significant decreases in local connections [48]. The decreased local cliques could have been related to higher depression scores in the C-group than in the HC group.…”

Section: Changes Of Network Measurementmentioning

confidence: 93%

Connectome analysis of brain functional network alterations in breast cancer survivors with and without chemotherapy

et al. 2020

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Treatment modalities for breast cancer, the leading cause of cancer-related deaths in women worldwide, include surgery, radiotherapy, adjuvant chemotherapy, targeted therapy, and hormonal therapy. The advancement in medical technology has facilitated substantial reduction in breast cancer mortality. However, patients may experience cognitive impairment after chemotherapy. This phenomenon called chemotherapy-induced cognitive impairment (i.e., "chemobrain") is common among breast cancer survivors. However, cognitive function deficits may exist before chemotherapy initiation. This study examined the functional network alterations in breast survivors by using resting-state functional magnetic resonance imaging (fMRI). Methods We recruited 172 female participants and separated them into three groups: C+ (57 breast cancer survivors who had finished 3-12-month-long chemotherapy), C-(45 breast cancer survivors who had not undergone chemotherapy), and HC (70 participants with no breast cancer history). We analyzed mean fractional amplitudes of low-frequency fluctuation and graph theoretical topologies from resting-state fMRI and applied network-based analysis to portray functional changes among the three groups. Results Among the three groups, the C-group demonstrated hyperactivity in the prefrontal cortex, bilateral middle temporal gyrus, right inferior temporal gyrus and right angular gyrus. Only the left caudate demonstrated significantly more hypoactivity in the C-group than in the C+ group. Graph theoretical analysis demonstrated that the brains of the C+ group became

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“…Because of basic differences between task‐based fMRI and rs‐fMRI, there are some advantages and disadvantages to these 2 methods. The 4 main advantages of rs‐fMRI are as follows: (1) simplifying and facilitating the examination; (2) standardized and reproducible; (3) no task requirement; and (4) wider use in clinical applications . For diffusion MRI, we adopted generalized q‐sampling imaging (GQI) as our feature set.…”

Section: Introductionmentioning

confidence: 99%

“…(3) no task requirement; and (4) wider use in clinical applications. 6 For diffusion MRI, we adopted generalized q-sampling imaging (GQI) as our feature set. GQI, 7 which is commonly used in diffusion MRI, is a nontensor tractographic method 8 based on the Fourier transform relation between diffusion signals and diffusion displacement.…”

Section: Introductionmentioning

confidence: 99%

Predicting chemo‐brain in breast cancer survivors using multiple MRI features and machine‐learning

Chen

Lin

Yeh

et al. 2018

Magnetic Resonance in Med

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Purpose Breast cancer (BC) is the most common cancer in women worldwide. There exist various advanced chemotherapy drugs for BC; however, chemotherapy drugs may result in brain damage during treatment. When a patient's brain is changed in response to chemo drugs, it is termed chemo‐brain. In this study, we aimed to construct machine‐learning models to detect the subtle alternations of the brain in postchemotherapy BC patients. Methods Nineteen BC patients undergoing chemotherapy and 20 healthy controls (HCs) were recruited for this study. Both groups underwent resting‐state functional MRI and generalized q‐sampling imaging (GQI). Results Logistic regression (LR) with GQI indices in standardized voxel‐wise analysis, LR with mean regional homogeneity in regional summation analysis, decision tree classifier (CART) with generalized fractional anisotropy in voxel‐wise analysis, and XGBoost (XGB) with normalized quantitative anisotropy had formidable performances in classifying subjects into a chemo‐brain group or an HC group. Classifying the brain MRIs of HC and postchemotherapy patients by conducting leave‐one‐out cross‐validation resulted in the highest accuracy of 84%, which was attained by LR, CART, and XGB with multiple feature sets. Conclusions In our study, we constructed the machine‐learning models that were able to identify chemo‐brains from normal brains. We are hopeful that these results will be helpful in clinically tracking chemo‐brains in the future.

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Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders

Cited by 26 publications

References 57 publications

Amygdala activity related to perceived social support

Amygdala activity related to perceived social support

Connectome analysis of brain functional network alterations in breast cancer survivors with and without chemotherapy

Predicting chemo‐brain in breast cancer survivors using multiple MRI features and machine‐learning

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