Perceived social support enhances well-being and prevents stress-related ill-being. A recent structural neuroimaging study reported that the amygdala volume is positively associated with perceived social support. However, it remains unknown how neural activity in this region and functional connectivity (FC) between this and other regions are related to perceived social support. To investigate these issues, resting-state functional magnetic resonance imaging was performed to analyze the fractional amplitude of low-frequency fluctuation (fALFF). Perceived social support was evaluated using the Multidimensional Scale of Perceived Social Support (MSPSS). Lower fALFF values in the bilateral amygdalae were associated with higher MSPSS scores. Additionally, stronger FC between the left amygdala and right orbitofrontal cortex and between the left amygdala and bilateral precuneus were associated with higher MSPSS scores. The present findings suggest that reduced amygdala activity and heightened connectivity between the amygdala and other regions underlie perceived social support and its positive functions.The subjective perception of social support (i.e., the feeling of being supported by other people) plays a crucial role in human resilience and well-being. A number of psychological studies have shown that perceived social support prevents ill-being, such as perceived stress, anxiety, and depression 1-5 and enhances well-being, such as subjective happiness 6-9 . To investigate this important psychological construct, psychometric studies have developed several questionnaires, including the Multidimensional Scale of Perceived Social Support (MSPSS 10 ), that reliably and validly measure perceived social support. Subjectively perceived social support is related to received social support, but at only moderate strength, whereas it is more consistently linked to the aforementioned positive effects 11,12 . Based on these findings, it has been proposed that perceived social support is a stable characteristic, similar to a trait or a personality feature 11,13 .To explore the neural mechanisms underlying perceived social support, a recent structural neuroimaging study has investigated the regional brain volumes associated with perceived social support as measured using the MSPSS 14 . The study reported that left amygdala volume is positively associated with MSPSS scores, which indicates that the amygdala plays an important role in the implementation of perceived social support.However, the type of amygdala activity (i.e., hyper-or hypoactivity) related to perceived social support remains unknown. This information would be valuable for understanding the functional role of the amygdala in perceived social support. Several functional magnetic resonance imaging (fMRI) studies have indicated that low-frequency (<0.1 Hz) resting-state neural activity in the absence of a task is a suitable measure for assessing brain activity related to stable psychological constructs, such as perceived social support 15,16 . It has been proposed that t...