Assessment of bony resection margins in oral cancer using elastic scattering spectroscopy: a study on archival material

Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus

“…[29][30][31][32][33] We have also successfully used ESS in the assessment of breast tissue and axillary nodes, 34 head and neck lymph nodes, 35 and bony resection margins in oral cancer. 36 As scattering is induced by gradients of the optical index of refraction, ESS spectral signatures will also be altered if the refractive index of nuclei or organelles changes, for example due to changes in the amount of granularity of the chromatin. 21 37 As aneuploidy is of prognostic importance in the development of oesophageal adenocarcinoma, it is interesting to speculate whether ESS could be used to detect it in vivo.…”

Evaluation of intraoperative cytological assessment of bone resection margins in patients with oral squamous cell carcinoma

“…A technically advanced approach described elastic scattering spectroscopy to identify positive bone margins. The study analyzed 341 elastic scattering spectroscopy spectra of mandibular specimens from 21 patients with a sensitivity of 87% and a specificity of 80% reported . However, even though promising and advanced solutions to overcome technical problems have been presented, to the best of our knowledge none of the previous studies provided a second cohort to validate their approach as an established application for routine clinical use (Table ).…”

“…The study analyzed 341 elastic scattering spectroscopy spectra of mandibular specimens from 21 patients with a sensitivity of 87% and a specificity of 80% reported. 28 However, even though promising and advanced solutions to overcome technical problems have been presented, to the best of our knowledge none of the previous studies provided a second cohort to validate their approach as an established application for routine clinical use ( Table 1). In contrast, we established and validated the ICAB to routinely assess cancellous bone specimens, including soft tissue, such as the inferior alveolar nerve.…”

“…Promising approaches have been presented to address this demand, including cytology . However, to our knowledge to date none of the approaches has obtained general acceptance, mostly due to the lack of practicability and reliability (Table 1) …”

“…[21][22][23][24][25][26][27] However, to our knowledge to date none of the approaches has obtained general acceptance, mostly due to the lack of practicability and reliability (Table 1). [21][22][23][24][25][26][27][28] The objective of the current study was to introduce the intraoperative cytological assessment of the bone resection margins (ICAB) in patients with OSCC and evaluate its practicability and diagnostic value for routine clinical use. The ICAB is intended to facilitate intraoperative decision-making for adequate bone resection to optimize therapeutic concepts.…”