Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus

Lovat, Laurence; Johnson, Kristie; Mackenzie, Gary D.; Clark, Benjamin R.; Novelli, Marco; Davies, Susan; O’Donovan, Maria; Selvasekar, Chelliah; Thorpe, Sally; Pickard, David Christopher O.; Fitzgerald, Rebecca; Fearn, Tom; Bigio, Irving J.; Bown, Stephen G.

doi:10.1136/gut.2005.081497

Cited by 125 publications

(78 citation statements)

References 35 publications

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“…An optical probe can be inserted through the instrument channel of the endoscope to give a measurement, which eliminates the problems of observer variability. This technique has been shown to have a high sensitivity (92%), but poor specificity (60%) (Lovat et al, 2006). However, prospective validation is awaited and elastic scattering spectroscopy does not circumvent the problem of sampling error, as it does not allow sampling of the entire segment.…”

Section: Elastic Scattering Spectroscopymentioning

confidence: 99%

Early diagnosis of oesophageal cancer

2009

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Squamous cell carcinoma and adenocarcinoma of the oesophagus are cancers that develop from distinct epithelial sub-types; however, they are both related to chronic inflammation of differing aetiologies. Inflammation leads to somatically inherited genetic mutations altering control of the cell cycle, DNA replication and apoptosis, which together result in autonomous and uncontrolled proliferation. These cancers have often metastasised to lymph nodes and distant organs before symptomatic presentation and therefore carry a poor prognosis. It is therefore vital to diagnose oesophageal cancer at an early stage, before the development of symptoms, when treatment can dramatically improve prognosis. Understanding the pathogenesis of these cancers is vital to guide early diagnostic strategies.

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Section: Elastic Scattering Spectroscopymentioning

confidence: 99%

Early diagnosis of oesophageal cancer

2009

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“…More advanced fibre optic probes for PLSS made use of gradient-index (GRIN) lens to implement depth selective measurement from a range of near surface depths (100-200 mm) to interrogate blood supply [66,67]. A great number of translational studies for diagnosis of breast cancer [68], prostate cancer [69], intraoperative determination of sentinel lymph node status in the breast [70], colonic lesions [71], oral premalignancy [72], high grade dysplasia and cancer in Barrett's oesophagus [73,74], cervix neoplasia [75,76], investigation of the nature of aceto-whitening in cervix cancer inspection [77][78][79][80][81][82], gold nanoparticle sizing [83], and monitoring apoptosis in cell cultures [84][85][86] have demonstrated that LSS provides a promising solution for cell culture monitoring, tissue surveillance and biopsy guidance in a relatively simple and cost effective configuration.…”

Section: Polarized Light and Biological Tissuementioning

confidence: 99%

Mueller polarimetric imaging for surgical and diagnostic applications: a review

2017

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Polarization is a fundamental property of light and a powerful sensing tool that has been applied to many areas. A Mueller matrix is a complete mathematical description of the polarization characteristics of objects that interact with light, and is known as a transfer function of Stokes vectors which characterise the state of polarization of light. Mueller polarimetric imaging measures Mueller matrices over a field of view and thus allows for visualising the polarization characteristics of the objects. It has emerged as a promising technique in recent years for tissue imaging, improving image contrast and providing a unique perspective to reveal additional information that cannot be resolved by other optical imaging modalities. This review introduces the basis of the Stokes-Mueller formulism, interpretation methods of Mueller matrices into fundamental polarization properties, polarization properties of biological tissues, and considerations in the construction of Mueller polarimetric imaging devices for surgical and diagnostic applications, including primary configurations, optimization procedures, calibration methods as well as the instrument polarization properties of several widelyused biomedical optical devices. The paper also reviews recent progress in Mueller polarimetric endoscopes and fibre Mueller polarimeters, followed by the future outlook in applying the technique to surgery and diagnostics. Tissue polarization properties convey morphological, micro-structural and compositional information of tissue with great potential for label free characterization of tissue pathological changes. Recent progress in tissue polarimetric imaging and polarization resolved endoscopy paved the way for translation of polarimetric imaging to surgery and tissue diagnosis.

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“…Three common spectroscopic techniques are Raman spectroscopy (RS), diffuse reflectance spectroscopy (DRS), and laser-induced fluorescence spectroscopy (LIFS). These techniques have been applied -either individually or in combinations -throughout the entire human body to investigate a wide range of pathologies including: atherosclerosis, 1, 2 osteoporosis, 3 brain edema, 4 cataract formation, 5 kidney stones, 6,7 and diabetes 8 and cancer of the breast, 9-11 cervix, 12 esophagus, 13,14 gastrointestinal tract, 15,16 brain, 17 lungs, 18,19 ovaries, 20 and bladder. 21 Here, we present a novel multimodal spectroscopy (MMS) device, combining RS, LIFS, and DRS, for the purpose of fast and non-invasive early detection of skin cancer which uses a variety of instrumentation and a custom contact probe capable of delivering and collecting light for all three modalities.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

Sharma

Marple²,

Reichenberg

et al. 2014

Review of Scientific Instruments

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The design and characterization of an instrument combining Raman, fluorescence, and reflectance spectroscopic modalities is presented. Instrument development has targeted skin cancer applications as a novel fiber-optic probe has been specially designed to interrogate cutaneous lesions. The instrument is modular and both its software and hardware components are described in depth. Characterization of the fiber-optic probe is also presented, which details the probe's ability to measure diagnostically important parameters such as intrinsic fluorescence and absorption and reduced scattering coefficients along with critical performance metrics such as high Raman signal-to-noise ratios at clinically practical exposure times. Validation results using liquid phantoms show that the probe and system can extract absorption and scattering coefficients with less than 10% error. As the goal is to use the instrument for the clinical early detection of skin cancer, preliminary clinical data are also presented, which indicates our system's ability to measure physiological quantities such as relative collagen and nicotinamide adenine dinucleotide concentration, oxygen saturation, blood volume fraction, and mean vessel diameter.

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Elastic scattering spectroscopy accurately detects high grade dysplasia and cancer in Barrett's oesophagus

Cited by 125 publications

References 35 publications

Early diagnosis of oesophageal cancer

Early diagnosis of oesophageal cancer

Mueller polarimetric imaging for surgical and diagnostic applications: a review

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

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