Assessment of bone morphogenic protein and hydroxyapatite–titanium dioxide composites for bone implant materials

Chen, Hsien‐Te; Shu, Hui-Ying; Chung, Chi-Jen; He, Ju-Liang

doi:10.1016/j.surfcoat.2015.06.056

Cited by 20 publications

(3 citation statements)

References 43 publications

(48 reference statements)

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“…Among all metal materials, titanium (Ti) and its alloys exhibit the best biological compatibility, excellent corrosion resistance, non-toxicity and a much lower elastic modulus compared to stainless steel and cobalt-chromium alloys (the elastic modulus of stainless steel is 200 GPa, cobalt-chromium alloys – 210 GPa, titanium – 110 GPa) [[13], [14], [15]]. Although Ti and its alloys are biocompatible, unfortunately, they are bioinert materials [16,17], hence they do not create conditions for osteointegration with bone tissue.…”

Section: Introductionmentioning

confidence: 99%

Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating

Sedelnikova

Комарова

Sharkeev

et al. 2019

Bioactive Materials

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The current research is devoted to the study of the modification of the titanium implants by the micro-arc oxidation with bioactive calcium phosphate coatings containing Ag or Sr and Si elements. The coatings’ microstructure, phase composition, morphology, physicochemical and biological properties were examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). Ag-containing and Sr-Si-incorporated coatings were formed in alkaline and acid electrolytes, respectively. The formation of the coatings occurred at different ranges of the applied voltages, which led to the significant difference in the coatings properties. The trace elements Ag, Sr and Si participated intensively in the plasma-chemical reactions of the micro-arc coatings formation. Ag-containing coatings demonstrated strong antibacterial effect against Staphylococcus aureus AТСС 6538-P. MTT in vitro test with 3T3-L1 fibroblasts showed no cytotoxicity appearance on Sr-Si-incorporated coatings.

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Section: Introductionmentioning

confidence: 99%

Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating

Sedelnikova

Комарова

Sharkeev

et al. 2019

Bioactive Materials

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“…All of these features lead to a reduction in bone healing time at a bone-implant surface. 90 Mohammadi et al completed an experiment to compare the impact of SiO 2 , TiO 2 and SiC on enhancement of setting time, mechanical strength and hydraulic reaction of calcium phosphate bone cement. Their results indicated that TiO 2 NPs are an excellent addition to enhance mechanical strength of calcium phosphate cement in the short-term.…”

Section: Bone Implantsmentioning

confidence: 99%

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Jafari¹,

Mahyad²,

Hashemzadeh³

et al. 2020

IJN

251

116

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Titanium dioxide (TiO 2) nanostructures are one of the most plentiful compounds that have emerged in various fields of technology such as medicine, energy and biosensing. Various TiO 2 nanostructures (nanotubes [NTs] and nanowires) have been employed in photoelectrochemical (PEC) biosensing applications, greatly enhancing the detection of targets. TiO 2 nanostructures, used as reinforced material or coatings for the bare surface of titanium implants, are excellent additive materials to compensate titanium implants deficiencies-like poor surface interaction with surrounding tissues-by providing nanoporous surfaces and hierarchical structures. These nanostructures can also be loaded by diversified drugs-like osteoporosis drugs, anticancer and antibiotics-and used as local drug delivery systems. Furthermore, TiO 2 nanostructures and their derivatives are new emerging antimicrobial agents to overcome human pathogenic microorganisms. However, like all other nanomaterials, toxicity and biocompatibility of TiO 2 nanostructures must be considered. This review highlights recent advances, along with the properties and numerous applications of TiO 2-based nanostructure compounds in nano biosensing, medical implants, drug delivery and antibacterial fields. Moreover, in the present study, some recent advances accomplished on the pharmaceutical applications of TiO 2 nanostructures, as well as its toxicity and biocompatibility, are presented.

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“…Introduction Titanium dioxide (TiO 2 ) has been widely studied in the last few decades because of its potential applications including photocatalysis, structural ceramics, dye-sensitized solar cells, sensors, biocompatible materials, etc. [1][2][3][4][5]. Many efforts have been made to explore TiO 2 based phosphors doped with various rare earth ions as luminescence materials, because of their excellent luminescence characteristics with sharp emission bands originating from the electronic transition between f levels [6][7][8][9][10][11][12].…”

mentioning

confidence: 99%

Structural, photoluminescent and photocatalytic properties of TiO2:Eu3+ coatings formed by plasma electrolytic oxidation

Stojadinović

Radić

Grbić

et al. 2016

Applied Surface Science

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Assessment of bone morphogenic protein and hydroxyapatite–titanium dioxide composites for bone implant materials

Cited by 20 publications

References 43 publications

Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating

Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating

<p>Biomedical Applications of TiO<sub>2</sub> Nanostructures: Recent Advances</p>

Structural, photoluminescent and photocatalytic properties of TiO2:Eu3+ coatings formed by plasma electrolytic oxidation

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