Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating

Sedelnikova, M. B.; Комарова, Е. Г.; Sharkeev, Yurii P.; Ugodchikova, A. V.; Толкачева, Т. В.; Rau, Julietta V.; Buyko, E. E.; Иванов, В. В.; Sheikin, Vladimir V.

doi:10.1016/j.bioactmat.2019.07.001

Cited by 62 publications

(27 citation statements)

References 53 publications

(64 reference statements)

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“…However, the residual discharges affected the particles so a partial change in the structure of calcium phosphates have taken place. Similar mechanism of microarc coating formation was confirmed in other previous researches [33,34].…”

Section: Discussionsupporting

confidence: 90%

“…As a result, the roughness (Ra) of samples reached 0.3-0.6 µm. Micro-Arc 3.0 installation was used to realize the MAO method for deposition of coatings as reported in the previous papers [33,34]. The electrolyte solution consisted of the following components: Na 2 HPO 4 , 10-30 g/L; NaOH, 3-5 g/L; NaF, 1.5-3.0 g/L; and Sr-HA (Ca 7.5 Sr 2.5 (PO 4 ) 6 (OH) 2 ) or Sr-TCP (Ca 2 Sr(PO 4 ) 2 ), 40-60 g/L.…”

Section: Sample Preparationmentioning

confidence: 99%

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Comparative Study of the Structure, Properties, and Corrosion Behavior of Sr-Containing Biocoatings on Mg0.8Ca

et al. 2020

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A comparative analysis of the structure, properties and the corrosion behavior of the micro-arc coatings based on Sr-substituted hydroxyapatite (Sr-HA) and Sr-substituted tricalcium phosphate (Sr-TCP) deposited on Mg0.8Ca alloy substrates was performed. The current density during the formation of the Sr-HA coatings was higher than that for the Sr-TCP coatings. As a result, the Sr-HA coatings were thicker and had a greater surface roughness Ra than the Sr-TCP coatings. In addition, pore sizes of the Sr-HA were almost two times larger. The ratio (Ca + Sr + Mg)/P were equal 1.64 and 1.47 for Sr-HA and Sr-TCP coatings, respectively. Thus, it can be assumed that the composition of Sr-HA and Sr-TCP coatings was predominantly presented by (Sr,Mg)-substituted hydroxyapatite and (Sr,Mg)-substituted tricalcium phosphate. However, the average content of Sr was approximately the same for both types of the coatings and was equal to 1.8 at.%. The Sr-HA coatings were less soluble and had higher corrosion resistance than the Sr-TCP coatings. Cytotoxic tests in vitro demonstrated a higher cell viability after cultivation with extracts of the Sr-HA coatings.

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Section: Discussionsupporting

confidence: 90%

Section: Sample Preparationmentioning

confidence: 99%

Comparative Study of the Structure, Properties, and Corrosion Behavior of Sr-Containing Biocoatings on Mg0.8Ca

et al. 2020

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“…Nevertheless, the histological score of the Porous group revealed less severe changes in comparison to the Infection group. The long-term silver nanoparticle release may have prevented the progress of the osteomyelitis as the antibacterial characteristics of silver are well known [ [61] , [62] , [63] ]. Our previous study demonstrated a silver release in vitro and detected 14% release within the first day and 16% after 28 days [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections

Ständert

Borcherding

Bormann

et al. 2021

Bioactive Materials

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Artificial prostheses for joint replacement are indispensable in orthopedic surgery. Unfortunately, the implanted surface is attractive to not only host cells but also bacteria. To enable better osteointegration, a mechanically stable porous structure was created on a titanium surface using laser treatment and metallic silver particles were embedded in a hydrophilic titanium oxide layer on top. The laser structuring resulted in unique amphora-shaped pores. Due to their hydrophilic surface conditions and capillary forces, the pores can be loaded preoperative with the antibiotic of choice/need, such as gentamicin. Cytotoxicity and differentiation assays with primary human osteoblast-like cells revealed no negative effect of the surface modification with or without gentamicin loading. An in vivo biocompatibility study showed significantly enhanced osteointegration as measured by push-out testing and histomorphometry 56 days after the implantation of the K-wires into rat femora. Using a S. aureus infection model, the porous, silver-coated K-wires slightly reduced the signs of bone destruction, while the wires were still colonized after 28 days. Loading the amphora-shaped pores with gentamicin significantly reduced the histopathological signs of bone destruction and no bacteria were detected on the wires. Taken together, this novel surface modification can be applied to new or established orthopedic implants. It enables preoperative loading with the antibiotic of choice/need without further equipment or post-coating, and supports osteointegration without a negative effect of the released dug, such as gentamicin.

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“…Plasma deposition has a wide application as a coating technology for intraosseous implants due to the advantage of obtaining coatings with a required porosity and microrelief of the surface [ 5 ]. Among the calcium phosphate coatings, the most promising are those based on tricalcium phosphate (Ca 3 (PO 4 ) 2 , TCP), characterized by good biocompatibility and resorbability in body fluids [ 6 , 7 , 8 ]. Indeed, the solubility of TCPs in water is higher than that of hydroxyapatite (HA) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Properties of Manganese-Substituted Tricalcium Phosphate Coatings for Titanium Biomedical Implants Deposited by Arc Plasma

et al. 2020

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Bioactive manganese (Mn)-doped ceramic coatings for intraosseous titanium (Ti) implants are developed. Arc plasma deposition procedure is used for coatings preparation. X-ray Diffraction, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy, and Electron Paramagnetic Resonance (EPR) methods are applied for coatings characterization. The coatings are homogeneous, composed of the main phase α-tricalcium phosphate (α-TCP) (about 67%) and the minor phase hydroxyapatite (about 33%), and the Mn content is 2.3 wt%. EPR spectroscopy demonstrates that the Mn ions are incorporated in the TCP structure and are present in the coating in Mn2+ and Mn3+ oxidation states, being aggregated in clusters. The wetting contact angle of the deposited coatings is suitable for cells’ adhesion and proliferation. In vitro soaking in physiological solution for 90 days leads to a drastic change in phase composition; the transformation into calcium carbonate and octacalcium phosphate takes place, and no more Mn is present. The absence of antibacterial activity against Escherichia coli, Enterococcus faecalis, and Pseudomonas aeruginosa bacteria strains is observed. A study of the metabolic activity of mouse fibroblasts of the NCTC L929 cell line on the coatings using the MTT (dye compound 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test demonstrates that there is no toxic effect on the cell culture. Moreover, the coating material supports the adhesion and proliferation of the cells. A good adhesion, spreading, and proliferative activity of the human tooth postnatal dental pulp stem cells (DPSC) is demonstrated. The developed coatings are promising for implant application in orthopedics and dentistry.

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Modification of titanium surface via Ag-, Sr- and Si-containing micro-arc calcium phosphate coating

Cited by 62 publications

References 53 publications

Comparative Study of the Structure, Properties, and Corrosion Behavior of Sr-Containing Biocoatings on Mg0.8Ca

Comparative Study of the Structure, Properties, and Corrosion Behavior of Sr-Containing Biocoatings on Mg0.8Ca

Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections

In Vitro Properties of Manganese-Substituted Tricalcium Phosphate Coatings for Titanium Biomedical Implants Deposited by Arc Plasma

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