Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging

Karan, Nazife Begüm; Arıcıoğlu, Banu

doi:10.1007/s00784-019-03003-x

Cited by 25 publications

(29 citation statements)

References 39 publications

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“…2010, Rohilla et al . 2017, Verma 2017, Genena 2019, Garg 2020, Karan & Aricioğlu 2020, Meschi et al . 2020), six had a follow‐up period of less than one year (Del Fabbro et al .…”

Section: Resultsmentioning

confidence: 99%

“…Parmar et al 2019,. Karan & Aricioğlu 2020). There is a need for clear and standard criteria for assessing 3D radiographic results.…”

Section: Discussionmentioning

confidence: 99%

“…The results reveal that the use of APCs promoted a better healing outcome after endodontic surgery, but no significant difference was achieved. In the excluded RCT (Karan & Aricioğlu 2020), although the radiographic outcomes were not evaluated following the criteria described by Rud et al . (1972) and Molven et al .…”

Section: Discussionmentioning

confidence: 99%

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Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

2020

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Background Regenerative techniques are increasingly applied in endodontic surgery, but different materials used in regenerative techniques may have varying impacts on wound healing. Objectives This study evaluated the effects of different regenerative techniques and materials on the outcome of endodontic surgery. Participants: patients with persistent periapical lesions, treated with root‐end surgery. Control: endodontic surgery without the use of regenerative techniques/materials. Intervention: endodontic surgery with the use of regenerative techniques/materials. Outcome: combined clinical and radiographic results. Methods PubMed, Web of Science, Embase, SinoMed and the CENTRAL Cochrane were searched up to 10th July 2020, followed by a manual search. Detailed eligibility criteria were applied. Cochrane’s risk‐of‐bias tool 2.0 was used to assess the risk of bias of the eligible studies. Meta‐analysis was conducted using RevMan software. Subgroup analyses were performed based on the regenerative materials used in endodontic surgery. Results Eleven eligible randomized controlled trials (RCTs) were included in the meta‐analysis: two had a low risk of overall bias, and nine had some concerns of overall bias. Generally, the use of regenerative techniques significantly improved the outcome of endodontic surgery (risk ratio [RR]: 0.42; 95% confidence interval [CI], 0.26–0.68; P < 0.001). On subgroup analysis, the use of expanded polytetrafluoroethylene (e‐PTFE) membranes alone had no added benefits (RR: 2.00; 95% CI, 0.22–18.33; P = 0.54). The application of collagen membranes or autologous platelet concentrates (APCs) alone was associated with a trend for better outcomes (RR: 0.51; 95% CI, 0.20–1.25; P = 0.14) (RR: 0.55; 95% CI, 0.18–1.71; P = 0.30). The combined use of collagen membranes and bovine‐derived hydroxyapatite significantly improved the outcome (RR: 0.35; 95% CI, 0.17–0.75; P = 0.007). Discussion This systematic review evaluated the effects of collagen membranes, e‐PTFE membranes, APCs and bone grafting materials, providing detailed information about the risks and benefits of using each regenerative technique/material or its combination in endodontic surgery. Conclusions Regenerative techniques improve periapical lesion healing after endodontic surgery. The combined use of collagen membranes and bovine‐derived hydroxyapatite may be beneficial as an adjunct to endodontic surgery. In contrast, the positive efficacy of e‐PTFE membranes or APCs alone remains doubtful.

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“…2010, Rohilla et al . 2017, Verma 2017, Genena 2019, Garg 2020, Karan & Aricioğlu 2020, Meschi et al . 2020), six had a follow‐up period of less than one year (Del Fabbro et al .…”

Section: Resultsmentioning

confidence: 99%

“…Parmar et al 2019,. Karan & Aricioğlu 2020). There is a need for clear and standard criteria for assessing 3D radiographic results.…”

Section: Discussionmentioning

confidence: 99%

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Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

2020

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“…The use of REPs, along with apical surgery, has been advocated as an alternative clinical strategy for complex clinical cases with large periapical lesions. [ 18 ] Personalized cell therapy is another exciting avenue that can be further explored. In their case report, Meza et al managed a mature tooth with pulpitis by using autologous cellular therapy with mesenchymal stem cells from inflamed dental pulp and leukocyte platelet-rich fibrin.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude, and Perception Among Endodontists Toward Regenerative Endodontics

Mayya¹,

Naik²,

Paul³

et al. 2021

Journal of International Society of Preventive and Community Dentistry

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“…The use of PRF to improve the healing of endodontic lesion was successfully documented in recent literature by Popowicz et al, with 2 case reports at 1-year follow up [ 13 ], and also by Goyal et al with 3 case reports in a study in March 2020 [ 14 ]. However, in larger studies where the use of PRP was added to endodontic surgery, the difference in terms of bone quality compared to that of the control group was not statistically significant [ 15 ]. Betancourt et al used other platelet derivatives for this purpose such as L-PRF on a case of severe endoperiodontal injury, in which there was an important improvement only from the periodontal point of view [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

B.P.F.C.® Bio-Plasma® with Pure Growth Factors (BioPlasma®) Used for the Treatment of a Persistent Great Periapical Lesion of an Endodontically Treated Tooth: A New Therapeutic Option

Viganò

Disconzi

Bertini

et al. 2020

Case Reports in Dentistry

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The aim of this case report was to evaluate the efficacy of a new platelet-rich plasma preparation and its regenerative capacity of bone periapical tissue for the treatment of a very compromised endodontic treated tooth, with a periapical lesion of 1.5 cm in diameter, using a pure platelet concentrate. This is made without the use of anticoagulant or any type of activator, e.g., bovine thrombin, calcium chloride. For this reason, it has been called “Pure”; it is the B.P.F.C.® Bio-Plasma® with Pure Growth Factors (BioPlasma®) designed and developed by Dr. Raffaello Viganò. The patient has read and signed a written consent form. The study protocol was approved by the Ethics Committee for Human Studies, University of Varese. X-ray at 2 and 6 months and 4 years after endodontic surgery demonstrated the success of the treatment.

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Assessment of bone healing after mineral trioxide aggregate and platelet-rich fibrin application in periapical lesions using cone-beam computed tomographic imaging

Cited by 25 publications

References 39 publications

Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

Knowledge, Attitude, and Perception Among Endodontists Toward Regenerative Endodontics

B.P.F.C.® Bio-Plasma® with Pure Growth Factors (BioPlasma®) Used for the Treatment of a Persistent Great Periapical Lesion of an Endodontically Treated Tooth: A New Therapeutic Option

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