Assessment of axillary lymph nodes involvement in patients with breast cancer depending on the tumor size and its histological and nuclear grades

Bojić, Toplica; Djordjevic, N.; Karanikolić, Aleksandar; Filipovic, Sladjana; Granić, Miroslav; Poultsidi, Antigoni

doi:10.2298/vsp1205414b

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…It was also observed that 71.5% of the patients with tumors < 1.0 cm presented with morphologically altered lymph nodes, with US-FNA sensitivity being calculated to be 80% in this subgroup. Even with only 10-30% of the patients with tumors < 2.0 cm presenting with axillary involvement ( 25 - 27 ) , the above described results suggest that the most important predictive factors for malignancy and US-FNA positiveness are morphological lymph node alterations, independently of primary tumor size. A study with a larger sample in this population (stage T1) is required, as the need for axillary emptying has been under discussion for patients with invasive carcinoma even in cases where sentinel lymphadenectomy is positive in this specific subgroup ( 28 ) .…”

Section: Discussionmentioning

confidence: 87%

Axillary ultrasound and fine-needle aspiration in preoperative staging of axillary lymph nodes in patients with invasive breast cancer

et al. 2015

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ObjectiveTo propose an algorithm to determine the necessity for ultrasonography-guided fine-needle aspiration (US-FNA) in preoperative axillary lymph node staging of patients with invasive breast cancer.Materials and MethodsProspective study developed at National Cancer Institute. The study sample included 100 female patients with breast cancer referred for axillary staging by US-FNA.ResultsThe overall US-FNA sensitivity was set at 79.4%. The positive predictive value was calculated to be 100%, and the negative predictive value, 69.5%. The US-FNA sensitivity for lymph nodes with normal sonographic features was 0%, while for indeterminate lymph nodes it was 80% and, for suspicious lymph nodes, 90.5%. In the assessment of invasive breast tumors stages T1, T2 and T3, the sensitivity was respectively 69.6%, 83.7% and 100%. US-FNA could avoid sentinel node biopsy in 54% of cases.ConclusionAxillary ultrasonography should be included in the preoperative staging of all patients with invasive breast cancer. The addition of US-FNA in cases of lymph nodes suspicious for malignancy may prevent more than 50% of sentinel lymphadenectomies, significantly shortening the time interval to definitive therapy.

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Section: Discussionmentioning

confidence: 87%

Axillary ultrasound and fine-needle aspiration in preoperative staging of axillary lymph nodes in patients with invasive breast cancer

et al. 2015

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Biopsia selectiva del ganglio centinela posneoadyuvancia como herramienta en la valoración de la axila

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Tajahuerce

et al. 2014

Revista de Senología y Patología Mamaria

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Assessment of axillary lymph nodes involvement in patients with breast cancer depending on the tumor size and its histological and nuclear grades

Abstract: In breast cancer patients, there is a strong correlation between tumor size, its histological and nuclear grades and the risk of axillary lymph nodes involvement.

Cited by 2 publications

References 25 publications

Axillary ultrasound and fine-needle aspiration in preoperative staging of axillary lymph nodes in patients with invasive breast cancer

Axillary ultrasound and fine-needle aspiration in preoperative staging of axillary lymph nodes in patients with invasive breast cancer

Biopsia selectiva del ganglio centinela posneoadyuvancia como herramienta en la valoración de la axila

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