2015
DOI: 10.1590/0100-3984.2014.0121
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Abstract: ObjectiveTo propose an algorithm to determine the necessity for ultrasonography-guided fine-needle aspiration (US-FNA) in preoperative axillary lymph node staging of patients with invasive breast cancer.Materials and MethodsProspective study developed at National Cancer Institute. The study sample included 100 female patients with breast cancer referred for axillary staging by US-FNA.ResultsThe overall US-FNA sensitivity was set at 79.4%. The positive predictive value was calculated to be 100%, and the negativ… Show more

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Cited by 31 publications
(19 citation statements)
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“…The results of this study confirm, with a positive predictive value of 99.6%, the clinical utility of FNAC to direct treatment when the patient has a positive C5 FNAC. Other studies report a similarly low false‐positive rate of FNAC (0%‐1.6%) . Potential explanations for false‐positive FNACs include cytologic misinterpretation (eg, misreading myoepithelial cells or lymphocytes as breast epithelial cells) or inadequate sampling of the lymph nodes at the time of surgical dissection .…”
Section: Discussionsupporting
confidence: 66%
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“…The results of this study confirm, with a positive predictive value of 99.6%, the clinical utility of FNAC to direct treatment when the patient has a positive C5 FNAC. Other studies report a similarly low false‐positive rate of FNAC (0%‐1.6%) . Potential explanations for false‐positive FNACs include cytologic misinterpretation (eg, misreading myoepithelial cells or lymphocytes as breast epithelial cells) or inadequate sampling of the lymph nodes at the time of surgical dissection .…”
Section: Discussionsupporting
confidence: 66%
“…In patients with axillary nodal metastases confirmed on FNAC, the management options are axillary nodal clearance or neo‐adjuvant therapy to downstage disease prior to definitive surgery . FNAC has been shown to avoid an unnecessary SLNB in up to 50% of cases and may reduce healthcare costs . The results of this study confirm, with a positive predictive value of 99.6%, the clinical utility of FNAC to direct treatment when the patient has a positive C5 FNAC.…”
Section: Discussionmentioning
confidence: 97%
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“…In patients with clinically positive nodes, to determine whether ALND is needed, the panel recommends pathologic confirmation of malignancy using ultrasound-guided fine-needle aspiration (FNA) 14 or core biopsy of suspicious nodes. According to the NCCN panel, the recommendation for axillary dissection of level I and II nodes is limited to patients with biopsy-proven axillary metastases.…”
Section: Nccn Recommendationsmentioning
confidence: 99%
“…Lymph node biopsy may be performed using FNAC or CB [1]. The addition of US -FNAC in cases of suspicious for malignancy may prevent more than 50% of sentinel lymphadenectomies, significantly shortening the time interval to definitive surgery [2].…”
Section: Introductionmentioning
confidence: 99%