Assessment of Atrophic Gastritis Using the OLGA System

Satoh, Kiichi; Osawa, Hiroyuki; Yoshizawa, Mitsuyo; Nakano, Hidetoshi; Hirasawa, Tomosuke; Kihira, Ken; Sugano, Kentaro

doi:10.1111/j.1523-5378.2008.00599.x

Cited by 60 publications

(67 citation statements)

References 17 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…35 In contrast, the consistent association of GC only with OLGA stages III ⁄ IV identifies this (low-prevalence) population as an elective target for endoscopic surveillance. 16,17 In this long-term follow-up study, the prognostic impact of OLGA-staging was tested in a consecutive series of dyspeptic outpatients. Both at enrolment (T1) and at the end of the follow-up (T2), a vast majority of the patients (89% and 86%, respectively) featured low-stage (0-I-II) gastritis.…”

Section: Discussionmentioning

confidence: 99%

Gastritis OLGA‐staging and gastric cancer risk: a twelve‐year clinico‐pathological follow‐up study

Rugge¹,

Boni²,

Pennelli³

et al. 2010

Aliment Pharmacol Ther

234

180

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Gastritis OLGA‐staging and gastric cancer risk: a twelve‐year clinico‐pathological follow‐up study

Rugge¹,

Boni²,

Pennelli³

et al. 2010

Aliment Pharmacol Ther

234

180

View full text Add to dashboard Cite

show abstract

“…24 High OLGA stages (III, IV) were reported to have an association with a high risk of GC. 25,26 Randomisation, surgery and follow-up Patients were randomly assigned to one of two parallel groups with an equal allocation ratio. H. pylori-positive GC patients who were scheduled to have subtotal or laparoscopy-assisted distal gastrectomy were randomised to receive a 7-day course of rabeprazole 10 mg, clarithromycin 500 mg and amoxicillin 1000 mg, all twice daily (n = 95); or placebo (n = 95) before surgery.…”

Section: Study Populationmentioning

confidence: 99%

Randomised clinical trial: the effects ofHelicobacter pylorieradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer

Cho

Choi

Kook

et al. 2013

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…However, the prediction of high gastric cancer risk cannot be done using this classification system. The OLGA staging system has the capability to differentiate the high-risk cancer population (stages III/IV) from low risk gastric cancer population (stages 0/I/II) [13,20,21]. The low reported inter-observer agreement of the gastric atrophy staging [11] conducted to the proposal of a new staging system based on the assessment of severity and extension of intestinal metaplasia [12].…”

Section: Discussionmentioning

confidence: 99%

The Orientation of Gastric Biopsy Samples Improves the Interobserver Agreement of the OLGA Staging System

Cotruta

Gheorghe

Iacob

et al. 2017

JGLD

View full text Add to dashboard Cite

Background & Aims: Evaluation of severity and extension of gastric atrophy and intestinal metaplasia is recommended to identify subjects with a high risk for gastric cancer. The inter-observer agreement for the assessment of gastric atrophy is reported to be low. The aim of the study was to evaluate the inter-observer agreement for the assessment of severity and extension of gastric atrophy using oriented and unoriented gastric biopsy samples. Furthermore, the quality of biopsy specimens in oriented and unoriented samples was analyzed.Methods: A total of 35 subjects with dyspeptic symptoms addressed for gastrointestinal endoscopy that agreed to enter the study were prospectively enrolled. The OLGA/OLGIM gastric biopsies protocol was used. From each subject two sets of biopsies were obtained (four from the antrum, two oriented and two unoriented, two from the gastric incisure, one oriented and one unoriented, four from the gastric body, two oriented and two unoriented). The orientation of the biopsy samples was completed using nitrocellulose filters (Endokit®, BioOptica, Milan, Italy). The samples were blindly examined by two experienced pathologists. Inter-observer agreement was evaluated using kappa statistic for inter-rater agreement. The quality of histopathology specimens taking into account the identification of lamina propria was analyzed in oriented vs. unoriented samples. The samples with detectable lamina propria mucosae were defined as good quality specimens. Categorical data was analyzed using chi-square test and a two-sided p value <0.05 was considered statistically significant.Results: A total of 350 biopsy samples were analyzed (175 oriented / 175 unoriented). The kappa index values for oriented/unoriented OLGA 0/I/II/III and IV stages have been 0.62/0.13, 0.70/0.20, 0.61/0.06, 0.62/0.46, and 0.77/0.50, respectively. For OLGIM 0/I/II/III stages the kappa index values for oriented/unoriented samples were 0.83/0.83, 0.88/0.89, 0.70/0.88 and 0.83/1, respectively. No case of OLGIM IV stage was found in the present case series. Good quality histopathology specimens were described in 95.43% of the oriented biopsy samples, and in 89.14% of the unoriented biopsy samples, respectively (p=0.0275).Conclusion: The orientation of gastric biopsies specimens improves the inter-observer agreement for the assessment of gastric atrophy.Key words: – – – .Abbreviations: H. pylori: Helicobacter pylori; OLGA: operative link for gastritis assessment; OLGIM: operative link on intestinal metaplasia assessment.

show abstract

Assessment of Atrophic Gastritis Using the OLGA System

Abstract: Our results indicate that higher stages are found in patients with GC using the OLGA staging system and that the high risk of GC can be recognized. It is simple to use and useful for the assessment of the severity of atrophic gastritis.

Cited by 60 publications

References 17 publications

Gastritis OLGA‐staging and gastric cancer risk: a twelve‐year clinico‐pathological follow‐up study

Gastritis OLGA‐staging and gastric cancer risk: a twelve‐year clinico‐pathological follow‐up study

Randomised clinical trial: the effects ofHelicobacter pylorieradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer

The Orientation of Gastric Biopsy Samples Improves the Interobserver Agreement of the OLGA Staging System

Contact Info

Product

Resources

About