Assessment of Atrial Electromechanical Coupling and Influential Factors in Nonrheumatic Paroxysmal Atrial Fibrillation

Cui, Qiqiong; Zhang, Wei; Wang, Hu; Sun, Xing‐Guo; Wang, Rong; Yang, Huanyi; Meng, Xian-Qiang; Zhang, Yun; Wang, Hao

doi:10.1002/clc.20162

Cited by 125 publications

(168 citation statements)

References 15 publications

(15 reference statements)

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“…Interatrial electromechanical delay measured by TDI was well correlated with P dispersion calculated by surface ECG. These results are in accordance with Emiroglu et al (18) The prolongation of intraatrial and interatrial electromechanical delays and the inhomogeneous propagation of sinus impulses are well-known electrophysiologic characteristics of the atria prone to fibrillation (11,12). P wave dispersion is related to the inhomogenous and interrupted conduction of sinus impulses, intraatrially and interatrially (12).…”

Section: Discussionsupporting

confidence: 90%

“…Fibrosis and enlarged left atrial tissue prolong and divert the propagation of the action potential in left atrial tissue and cause multiple micro reentries resulting in AF (10). The prolongation of intraatrial and interatrial electromechanical delays (EMD) and the inhomogeneous propagation of sinus impulses are well-known electrophysiologic characteristics of the atria prone to fibrillation (11). P wave dispersion is related to the inhomogenous and interrupted conduction of sinus impulses, intraatrially and interatrially (12).…”

Section: Introductionmentioning

confidence: 99%

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Arterial Stiffness is Associated with Tissue Doppler Atrial Conduction Times and P Wave Dispersion in Hypertensive Patients

Elsherbiny

2012

Intern. Med.

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Background Arterial stiffness is strongly predictive for cardiovascular events in hypertensive individuals and it may increase the risk of stroke. This study was designed to evaluate the possible relationship between arterial stiffness and atrial electromechanical delay and P wave dispersion (PWD), as determinants of AF risk. Materials and MethodsThe study included 75 hypertensive patients and 45 healthy control subjects. Atrial electromechanical coupling (time interval from the onset of P wave on ECG to the beginning of A wave with tissue Doppler echocardiography [PA]), intraatrial and interatrial electromechanical delay (EMD) and PWD were measured. Stiffness index β & PWV was measured to assess the arterial stiffness. Results The interatrial EMD and PWD were prolonged in hypertensive patients compared to controls (p< 0.01 for both), There was increased arterial stiffness (PWV and stiffness index β) in hypertensive patients compared to controls (6.43 ± 1.73 vs. 4.8 ± 1.6 m/sec & 4.9 ± 2.8 vs. 2.63 ± 1.2, p<0.01 for both). By multivariate analysis; PWV and Stiffness index β were independently correlated with interatrial EMD (B ± SE= 0.42 ± 1.87, B ± SE=0.39 ± 0.21 p<0.01 for both) and PWD (B ± SE=0.37 ± 1.93, p<0.01, B ± SE=0.25 ± 0.18, p<0.05 respectively). Conclusion In hypertensive patients arterial stiffness indexes increased and showed a significant correlation with interatrial EMD and PWD independent of other variables. Further research is needed to determine whether interventions that reduce arterial stiffness will limit the growing incidence of AF.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Arterial Stiffness is Associated with Tissue Doppler Atrial Conduction Times and P Wave Dispersion in Hypertensive Patients

Elsherbiny

2012

Intern. Med.

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“…In some studies, a relationship between LA diameter and interatrial electromechanical delay has been found (20)(21)(22)(23)(24)(25). Such a relation was observed in our study.…”

Section: Discussionsupporting

confidence: 87%

Coronary artery ectasia is associated with atrial electrical and mechanical dysfunction: an observational study

Öztürk¹,

Özyaşar²,

Ayhan³

et al. 2012

Anadolu Kardiyol Derg

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Objective: The aim of our study was to investigate total atrial conduction time and left atrial (LA) mechanical function in patients with isolated coronary artery ectasia (ICAE). Methods: Sixty patients with ICAE without any visible coronary stenosis were enrolled to this cross-sectional observational study. The control group consisted of 40 age-and gender-matched patients. Left atrial mechanical functions were measured by the method of discs in the apicalfour chamber echocardiographic view. LA mechanical function parameters were calculated. P wave dispersion was measured on electrocardiography (ECG). The total atrial conduction time (PA-tissue Doppler imaging (TDI) duration) was assessed by measuring the time interval between the beginning of the P wave on the surface ECG and point of the peak A wave on TDI from LA lateral wall just over the mitral annulus. Student t, Mann-Whitney U, Pearson's, and Spearman's correlation analysis and multiple regression analysis were used for statistical analysis. Results: The clinical and laboratory characteristics were similar in two groups. Both groups were similar in terms of Vmax and LA total emptying volume (29.0±7.3 vs. 31.9±6.5 mL/m 2 , p=0.082 and 19.9±5.1 vs. 20.0±5.2 mL/m 2 , p=0.821). However, LA passive emptying volume and LA passive emptying fraction were significantly decreased with ICAE patients (11.1±3.2 vs. 13.5±3.8 ml/m 2 , p=0.005 and 35.2±7.2 vs. 47.8±9.4 mL/m 2 , p<0.001). But LA active emptying volume and LA active emptying fraction were significantly increased in ICAE patients (9.1±2.6 vs. 6.4±3.0 mL/m 2 , p<0.001 and 45.3±8.1 vs. 40.7±6.7 mL/m 2 , p=0.002). PA-TDI duration was measured significantly higher in patients with ICAE than control group (131.8±5.7 vs. 114.4±9.1 ms, p<0.001). Multiple linear regression analyses showed that ectatic segment number was an independent factor of PA-TDI duration (b=0.581, 95% CI=4. 046-6.295, p<0.001). Conclusion: Our study demonstrated presence of LA electrical and mechanical dysfunction in patients with ICAE. LA dysfunction may be associated with cardiac pathologies as arrhythmias, decrease in cardiac output and congestive failure. (Anadolu Kardiyol Derg 2012; 12: 637-43)

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“…This issue has been evaluated non-invasively by several alternative techniques such as P-wave dispersion and tissue Doppler imaging (TDI) [7,8]. However, data on the potential relationship between atrial EMD evaluated by TDI, atrial electrophysiological changes and AF promotion are sparse.…”

Section: Introductionmentioning

confidence: 99%

Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

Fu¹,

Liu²,

Li³

et al. 2013

Cardiol J.

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Assessment of Atrial Electromechanical Coupling and Influential Factors in Nonrheumatic Paroxysmal Atrial Fibrillation

Cited by 125 publications

References 15 publications

Arterial Stiffness is Associated with Tissue Doppler Atrial Conduction Times and P Wave Dispersion in Hypertensive Patients

Arterial Stiffness is Associated with Tissue Doppler Atrial Conduction Times and P Wave Dispersion in Hypertensive Patients

Coronary artery ectasia is associated with atrial electrical and mechanical dysfunction: an observational study

Impaired atrial electromechanical function and atrial fibrillation promotion in alloxan-induced diabetic rabbits

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