In this study, the effects of certain cleaning chemicals on the surface properties of a specific marble sample (Bilecik beige) were investigated as a function of chemical type, chemical concentration, and contact time. Descaler, diluted HCl (spirits of salt), soft soap, surface cleaner, bleach, diluted nitric acid, liquid scouring cream, dish soap, grease cleaner and synthetic thinner were used in the tests as cleaning chemicals. It was observed that the contact of highly acidic chemicals (nitric acid, salt of sipits, and descaler) on the marble surfaces for 840 h increased the surface roughness to unmeasurable point. In addition, surface glossiness of the marble was completely disappeared, loss in mass of marble was more than 1%, and surface color was changed. Neutral and alkaline chemicals, however, changed marble surface properties slightly compared to acidic chemicals.