Assessment of arterial stiffness in chronic obstructive pulmonary disease by a novel method

Aykan, Ahmet Çağrı; Gökdeniz, Tayyar; Boyacı, Faruk; Gül, İlker; Hatem, Engin; Kalaycıoğlu, Ezgi; Turhan, Turan; Bektaş, H.; Çilingir, M.B.; Aykan, Duygun Altıntaş; Ayyildiz, Fatih Alper; Altun, Selma

doi:10.1007/s00059-013-3902-3

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…Many [ 4 – 10 ], but not all [ 11 , 12 ], of the studies showed that reduced pulmonary function was associated with a higher risk of vascular dysfunction. The discrepancy could be due to interaction, diffrences in study design and, study population (patients or relatively healthy subjects), sample size, and variation in confounding factors considered [ 5 , 7 , 8 , 10 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

Pan

Lam

et al. 2018

BMC Pulm Med

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BackgroundFindings describing the relationship between pulmonary function and peripheral vascular function have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular Subcohort (GBCS-CVD).MethodsBrachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were measured by a waveform analyser, and pulmonary function by turbine flowmeter spirometry. Predicted forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were derived using equations for Chinese. Regression analyses were used to investigate the association.ResultsOf 1528 older Chinese, 980 (64.1%) had arterial stiffness (baPWV ≥1400 cm/s), but only 29 (1.9%) had peripheral arterial disease (PAD) (ABI < 0.9). The mean (±standard deviation, SD) baPWV was 1547 (±298) cm/s and mean (±SD) ABI 1.09 (±0.09). Before and after adjusting for potential confounders, baPWV was negatively associated with FEV1 and FVC % predicted (% predicted = observed/predicted × 100%) (adjusted β: − 0.95 and − 1.16 respectively, p < 0.05), and ABI was marginally non-significantly positively associated with FEV1% predicted (adjusted β 0.02, p = 0.32) and FVC% predicted (adjusted β 0.02, p = 0.18). Compared to participants in the highest tertile of pulmonary function, those in the lowest had higher risk of arterial stiffness (adjusted odds ratio (AOR) 1.51, 95% CI 1.09–2.10 for FEV1 and AOR 1.69, 95% CI 1.22–2.33 for FVC), but the higher risk of PAD was marginally non-significant (AOR 1.64, p = 0.42 for FEV1 and AOR 1.65, p = 0.24 for FVC).ConclusionIn older relatively healthy normal weight Chinese, pulmonary function was inversely dose-dependently associated with arterial stiffness, while the association with PAD was much weaker.

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Section: Introductionmentioning

confidence: 99%

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

Pan

Lam

et al. 2018

BMC Pulm Med

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“…Аналогичные данные были получены в различных рабо тах у больных ХОБЛ без ССЗ. По данным A. C. Aykan и соавт., у больных ХОБЛ сердечнолодыжечнососуди стый индекс, отражающий истинную жесткость арте рий, не зависящую от АД, был значительно увеличен и коррелировал с ОФВ 1 , индексом Тиффно и стадией ХОБЛ [15]. В мультицентровом рандомизированном исследовании, как было представлено в публикации S. P. Bhatt и соавт., у больных ХОБЛ СПВ в аорте была взаимосвязана не только с возрастом, уровнем САД, статусом курения, индексом кальцификации аорты, но и с ОФВ 1 по данным спирометрии [16].…”

Section: Discussionunclassified

Contribution of chronic obstructive pulmonary disease to remodeling of target organs in patients with arterial hypertension and ischemic heart disease associated with chronic heart failure

Козиолова¹,

Masalkina²,

Козлова³

et al. 2017

RHFJ

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Arterial stiffness in chronic obstructive pulmonary disease

Balta¹,

Aykan²

2014

Herz

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Assessment of arterial stiffness in chronic obstructive pulmonary disease by a novel method

Abstract: In this study, we have shown that increased arterial stiffness assessed by CAVI is associated with the spirometric severity of COPD.

Cited by 10 publications

References 21 publications

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD

Contribution of chronic obstructive pulmonary disease to remodeling of target organs in patients with arterial hypertension and ischemic heart disease associated with chronic heart failure

Arterial stiffness in chronic obstructive pulmonary disease

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