Assessment of antioxidant and neuroprotective activities of methanol extract of Moringa oleifera Lam. leaves in subchronic chlorpyrifos-intoxicated rats

Idoga, E. S.; Ambali, Suleiman Folorunsho; Ayo, Joseph Olusegun; Mohammed, Aliyu

doi:10.1007/s00580-018-2682-9

Cited by 9 publications

(8 citation statements)

References 52 publications

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“…The dysregulated antioxidant mechanism in the current model was consistent with previous reports (Han et al 2019;Shal et al 2020) , where an elevated MDA and reduced antioxidant mechanism in different brain regions were observed after CCl 4 intoxication. MOLE pretreatment successfully restored the antioxidative power in HC and CC by reducing MDA and restoring antioxidative mechanisms, consistent with Idoga et al (2018) . The reversed alterations of antioxidant power in MOLE/CCl 4 treated mice demonstrate the neuroprotective effect of MOLE and its prominent antioxidant capacity protecting against LPO.…”

Section: Discussionsupporting

confidence: 76%

Protective effect of Moringa oleifera Lam. leaf extract against oxidative stress, inflammation, depression, and apoptosis in a mouse model of hepatic encephalopathy

Mahmoud

El‐kott

AlGwaiz

et al. 2022

Environ Sci Pollut Res

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The present study aimed to assess the antioxidative, anti-in ammatory, antiapoptotic, and antidepression impacts of Moringa oleifera Lam. leaf ethanolic extract (MOLE) in the hippocampus and cerebral cortex of CCl 4 -induced mouse model of hepatic encephalopathy. High-performance liquid chromatography was used to detect marker compounds; rutin and β-sitosterol. Animals were divided into four groups; vehicle group, CCl 4 treated group, MOLE treated group, and (CCl 4 + MOLE) group treated with MOLE for 14 days before CCl 4 -induced neurotoxicity. MOLE decreased alanine aminotransferase, aspartate aminotransferase, corticosterone, and ammonia levels in serum and improved the antioxidant status of CCl 4 treated mice in the hippocampus and cerebral cortex. It reduced the expression of toll-like receptor (TLR)4, TLR2, myeloid differentiation primary response 88 (MYD88), and nuclear factor-kappa B (NF-κB) genes and the protein levels of the pro-inflammatory cytokines. MOLE also attenuated apoptosis, as revealed by the reduced expression of caspase3, and prevented histological deterioration. Furthermore, MOLE attenuated CCl 4 -induced anxiety and depression-like behavioral changes. Collectively, MOLE modulates neuroin ammation, oxidative stress, TLR4/2-MyD88/NF-κB signaling, and apoptosis in the hippocampus and cerebral cortex of the hepatic encephalopathy experimental model.

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Section: Discussionsupporting

confidence: 76%

Protective effect of Moringa oleifera Lam. leaf extract against oxidative stress, inflammation, depression, and apoptosis in a mouse model of hepatic encephalopathy

Mahmoud

El‐kott

AlGwaiz

et al. 2022

Environ Sci Pollut Res

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show abstract

“…The dysregulated antioxidant mechanism in the current model was in line with previous reports 1,30 , in which an elevated MDA and reduced antioxidant mechanism in different brain regions were observed following CCl 4 intoxication. MOLE pretreatment successfully restored the antioxidative power in HC and CC through the reduction of MDA and restoration of antioxidative mechanisms which was in agreement with Idoga et al, (2018) 31 . The reversed alterations of antioxidant power in MOLE/CCl 4 treated mice indicate the neuroprotective effect of MOLE and its prominent antioxidant capacity protecting against LPO.…”

Section: Discussionsupporting

confidence: 90%

Protective effect of Moringa oleifera Lam. leaf extract against carbon tetrachloride-induced neuroinflammation in a mouse model of hepatic encephalopathy

Fathy

Mohammed

2021

Preprint

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Background Hepatic encephalopathy (HE) is a neuropsychiatric disorder associated with acute or chronic liver injury. Carbon tetrachloride (CCl4) is usually used as an experimental model for HE. The present study aimed to assess the neuroprotective impacts of Moringa oleifera Lam. leaf ethanolic extract (MOLE) against neurotoxicity in CCl4-induced mouse model of HE. Methods High-performance liquid chromatography (HPLC) analysis was used for the detection of marker compounds; rutin and β-sitosterol. Animals were divided into four groups; vehicle group, CCl4 treated group, MOLE treated group, and (CCl4 + MOLE) group treated with MOLE for 14 days before inducing neurotoxicity by CCl4. Results Pretreatment with MOLE decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), corticosterone, and ammonia levels in serum as well as it improved the antioxidant status of CCl4 treated mice in the tissue of hippocampus (HC) and cerebral cortex (CC). It reduced the expression of toll-like receptor (TLR)4, TLR2, myeloid differentiation primary response 88 (MYD88), and nuclear factor kappa B (NF-κB) genes and the protein levels of the pro-inflammatory cytokines in the selected brain regions. MOLE also exhibited anti-apoptotic effect as revealed by the reduced expression of caspase3, and prevented histological deteriorations caused by CCl4 treatment. Furthermore, CCl4-induced anxiety and depression-like behavioral changes were attenuated by MOLE preadministration. Conclusions Taken together, the current results suggest significant anxiolytic and antidepressant effects of MOLE via modulation of neuroinflammation, oxidative stress, TLR4/2-MyD88/NF-κB pathway, and apoptosis in HE experimental model.

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“…Besides that, the M. oleifera leaf methanol extract has been tested in sub-chronic chlorpyrifos (CPF)-intoxicated Wistar rats for its potential neuroprotective activities ( Idoga et al, 2018 ). CPF is a commonly used pesticide that is known to be a neurotoxicant as it stimulates oxidative damage to the tissues and leads to an increase in ROS.…”

Section: Neuroprotective and Anti-neuroinflammatory Effects Of ...mentioning

confidence: 99%

An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera

et al. 2023

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Neurodegenerative diseases (NDs) are sporadic maladies that affect patients’ lives with progressive neurological disabilities and reduced quality of life. Neuroinflammation and oxidative reaction are among the pivotal factors for neurodegenerative conditions, contributing to the progression of NDs, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), multiple sclerosis (MS) and Huntington’s disease (HD). Management of NDs is still less than optimum due to its wide range of causative factors and influences, such as lifestyle, genetic variants, and environmental aspects. The neuroprotective and anti-neuroinflammatory activities of Moringa oleifera have been documented in numerous studies due to its richness of phytochemicals with antioxidant and anti-inflammatory properties. This review highlights up-to-date research findings on the anti-neuroinflammatory and neuroprotective effects of M. oleifera, including mechanisms against NDs. The information was gathered from databases, which include Scopus, Science Direct, Ovid-MEDLINE, Springer, and Elsevier. Neuroprotective effects of M. oleifera were mainly assessed by using the crude extracts in vitro and in vivo experiments. Isolated compounds from M. oleifera such as moringin, astragalin, and isoquercitrin, and identified compounds of M. oleifera such as phenolic acids and flavonoids (chlorogenic acid, gallic acid, ferulic acid, caffeic acid, kaempferol, quercetin, myricetin, (-)-epicatechin, and isoquercitrin) have been reported to have neuropharmacological activities. Therefore, these compounds may potentially contribute to the neuroprotective and anti-neuroinflammatory effects. More in-depth studies using in vivo animal models of neurological-related disorders and extensive preclinical investigations, such as pharmacokinetics, toxicity, and bioavailability studies are necessary before clinical trials can be carried out to develop M. oleifera constituents into neuroprotective agents.

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Assessment of antioxidant and neuroprotective activities of methanol extract of Moringa oleifera Lam. leaves in subchronic chlorpyrifos-intoxicated rats

Cited by 9 publications

References 52 publications

Protective effect of Moringa oleifera Lam. leaf extract against oxidative stress, inflammation, depression, and apoptosis in a mouse model of hepatic encephalopathy

Protective effect of Moringa oleifera Lam. leaf extract against oxidative stress, inflammation, depression, and apoptosis in a mouse model of hepatic encephalopathy

Protective effect of Moringa oleifera Lam. leaf extract against carbon tetrachloride-induced neuroinflammation in a mouse model of hepatic encephalopathy

An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera

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