Assessment of Antibiotic Treatment of Cellulitis and Erysipelas

Brindle, Richard; Williams, O. Martin; Barton, Edward; Featherstone, Peter I.

doi:10.1001/jamadermatol.2019.0884

Cited by 59 publications

(35 citation statements)

References 61 publications

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“…The treatment should be directed against typical Gram-positive pathogens—specifically streptococcus species. A 5-day course of antibiotics may actually be as effective as 10 days’ worth [ 3 , 13 , 14 , 25 ]. To avoid recurrence, tissue maceration, edema, eczema, and venous insufficiency should be treated, though this may be difficult, especially in an ambulatory context [ 2 ].…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting

Silverberg

2021

Clinics and Practice

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The skin is the largest, and arguably, the most vulnerable organ in the human body. Scratches and scrapes, bites and puncture wounds, impetigo and erysipelas—all these disruptions can lead to pain, swelling, and/or systemic symptoms. In this article, which is based on the Infectious Diseases Society of America’s 2014 guidelines and the World Society of Emergency Surgery and Surgical Infection Society of Europe’s 2018 consensus statement, a structured approach to skin and soft tissue infections (SSTIs) is reviewed, comparing treatment for suppurative and non-suppurative infections, and then discussing specific conditions commonly seen in Primary Care and Urgent Care facilities.

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Section: Diagnosis and Treatmentmentioning

confidence: 99%

A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting

Silverberg

2021

Clinics and Practice

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“…Eine neue Metaanalyse auf der Basis von 43 Studien aus dem Jahr 2019 [6] kommt zu dem Schluss, dass es keine Evidenz dafür gibt, dass ein Antibiotikum in der Therapie überlegen ist und dass die intravenöse Applikation der oralen Gabe des Antibiotikums überlegen ist.…”

Section: Antibiotische Therapieunclassified

Diagnostik und Therapie des Erysipels: Ein Positionspapier der Initiative Chronische Wunden (ICW) e. V.

Kröger

Schwarzkopf²,

Eder

et al. 2021

Dtsch Med Wochenschr

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ZusammenfassungDas Erysipel ist eine bakterielle Weichgewebeinfektion, die durch β-hämolysierende Streptokokken verursacht wird und sich entlang der Lymphspalten der Haut nach proximal ausbreitet. Die Eintrittspforten der Erreger können kleinere Verletzungen oder auch chronische Wunden sein. Die Diagnose Erysipel wird klinisch durch die sich ausbreitende Rötung und Überwärmung der Haut, den reduzierten Allgemeinzustand mit Fieber und Schüttelfrost sowie mittels serologischer Entzündungsparameter gestellt und muss von zahlreichen Differenzialdiagnosen abgegrenzt werden. Die systemische Therapie erfolgt meist mit Penicillin. In der Lokaltherapie ist der Stellenwert der Maßnahmen wie Kompressionstherapie oder Kühlung derzeit noch umstritten. Insbesondere für die Rezidivprophylaxe sind die langfristige Therapie des Lymphödems sowie die konsequente Vermeidung und Therapie von Eintrittspforten essenziell.

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“…Detection of genetic tumour predisposition syndromes using electronic health records DOI: 10.1111/bjd.19215 DEAR EDITOR, The restricted tumour repertoire of certain genetic skin tumour syndromes, such as CYLD cutaneous syndrome (CCS), is well recognized. 1 Patients with CCS develop multiple benign cylindromas and spiradenomas, a presentation of skin appendageal tumours recognized to be exclusively associated with loss of CYLD function. 2 Consequently, pathology coding records, which capture tumourlevel data, can be interrogated to detect patients who may have undiagnosed CCS based on the presentation of multiple CCS-specific tumours over time.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…DEAR EDITOR, There is no evidence to support using an antibiotic for longer than 5 days in cellulitis. 1 The National Institute for Health and Care Excellence recommends specialist review if cellulitis has not improved after 14 days despite antibiotics. 2 The 2017 Cellulitis Priority Setting Partnership prioritized research into diagnosis and treatment of cellulitis.…”

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confidence: 99%

Longer duration of lower‐limb symptoms makes cellulitis diagnosis less likely in secondary care

Mistry

Levell

2020

Br J Dermatol

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Prior studies on other inflammatory diseases such as rheumatoid arthritis and systemic lupus erythematosus have shown that the disease influences rates of preterm birth and pregnancy loss. 2 No statistically significant differences were detected when comparing our study cohort with the general population of women in the US in terms of the rates of miscarriage, 3 C-section, 4 premature baby, 4 stillbirth 5 and perinatal mortality. 5 In addition, baseline HS disease severity was not significantly associated with poorer pregnancy or neonatal outcomes. Thus, our findings on pregnancy outcomes can help providers counsel and reassure concerned pregnant patients with HS regarding pregnancy outcomes. In contrast, compared with rates of gestational diabetes mellitus, 6 gestational hypertension 7 and pre-eclampsia 8 in the US general population, our study cohort had a higher than average rate for each condition, with statistical significance detected for gestational hypertension (P = 0Á022) and pre-eclampsia (P = 0Á017). Therefore, screening for these conditions among pregnant patients with HS is essential. Study limitations include: that it took place at a single academic centre, was retrospective and contained missing data. Lack of systematic follow-up of neonatal charts could have resulted in underestimation of the perinatal mortality rate. Only univariate analysis was conducted; thus, potential confounders have not been controlled for. In summary, our study suggests that HS does not portend an increased risk of poor pregnancy or neonatal outcomes. Large, prospective pregnancy registries are needed to collect data on maternal and neonatal outcomes in patients with HS.

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Assessment of Antibiotic Treatment of Cellulitis and Erysipelas

Cited by 59 publications

References 61 publications

A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting

A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting

Diagnostik und Therapie des Erysipels: Ein Positionspapier der Initiative Chronische Wunden (ICW) e. V.

Longer duration of lower‐limb symptoms makes cellulitis diagnosis less likely in secondary care

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