Assessment of antibacterial and anti-biofilm effects of zinc ferrite nanoparticles against Klebsiella pneumoniae

Sharma, Rashmi P.; Raut, Siddheshwar D.; Jadhav, Vijaykumar V.; Mulani, Ramjan M.; Kadam, Ambadas S.; Mane, Rajaram S.

doi:10.1007/s12223-022-00969-2

Cited by 7 publications

(8 citation statements)

References 53 publications

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“…There are studies that invitro zinc has the effect of inhibiting the formation of biofilms from K.pneumoniae. The results of this study are the same as the study which also shows that the greater the dose of zinc given, the inhibitory effect on the biofilm is also greater as evidenced by the the percentage of reduction in biofilm formation is getting bigger as the dose of zinc administered increases (Sharma et al, 2022).…”

Section: Results Discussionsupporting

confidence: 79%

Comparison dose effects of vitamin C and zinc administration to inhibit klebsiella pneumoniae biofilms formation

Setiawan

Agung

Muhammad

2022

ijhs

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Background: Klebsiella pneumoniae is a Gram-negative bacterium that form biofilm and causes various infections. Biofilms have important role in resistance to antibiotics. Alternative agents that can inhibit biofilms formation with minimal side effects is required. This study show effects of vitamin C and zinc to inhibit Klebsiella pneumoniae biofilms formation. Method: This experiment used clinically stored Klebsiella pneumoniae isolates using controls. Isolates other than control are exposed with vitamin C and zinc oral preparations with various doses invitro then Optical Density and percentage reduction in biofilm is calculated and compared. Results: Vitamin C and zinc had invitro-inhibiting effect on biofilms formation of Klebsiella pneumoniae at all doses. The differences in decrease of Optical Density biofilm from the doses used after statistical testing was significant (P < 0.05). The smallest Optical Density and the largest percentage of Optical Density reduction of biofilms is found in vitamin C 1000 mg and zinc 50 mg. Conclusion: There are differences in inhibition of biofilm formation Klebsiella pneumoniae in the administration of vitamin C and zinc, with higher dose of vitamin C and zinc, the inhibition of biofilms formation is greater.

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Section: Results Discussionsupporting

confidence: 79%

Comparison dose effects of vitamin C and zinc administration to inhibit klebsiella pneumoniae biofilms formation

Setiawan

Agung

Muhammad

2022

ijhs

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“…[24][25][26]29,30,36 Additionally, IONPs doped with transition metals shown significant antimicrobial activity based on the synthesis process, size, concentrations, and application. 25,30,50 Doped-IONPs were synthesized by using CP, CPA, MAP, GC, SGP, HDA, and solvothermal approach. However, the CP method was the most approached one due to its less complexity.…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…Doped-IONPs are composed of modified iron oxides by introducing foreign metals or elements into their structure. ,,,− Introduction of foreign metals, also known as dopants, into an empty crystal lattice alters the physicochemical, biological, electrical, as well as optical properties of the nanoparticles . Doped-IONPs can be synthesized by coprecipitation (CP), green combustion (GC), sol–gel process (SGP), chemical polymerization approach (CPA), microwave-assisted process (MAP), hydrothermal approach (HDA). ,,,,,− Multiple types of dopants, e.g. , cobalt, nickel, copper, zinc, and rare-earth elements are broadly applied for doping purposes. ,,,, At present, doped-IONPs have found widespread applications in drug delivery, antimicrobial and anticancer activities, MRI imaging agent. − Moreover, when doped-IONPs are employed as antimicrobial agents, transition metals are mainly utilized due to their antimicrobial characteristics in their bulk form …”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

“…One of the notable modifications is the enhancement of antimicrobial activity through different doping methods . Doped-IONPs sized around 20–200 nm have shown significant antimicrobial activity on different bacteria, where size less than 20 nm. ,, While doped-IONPs larger than 200 nm demonstrated comparatively poor antimicrobial activity. − ,,, Additionally, IONPs doped with transition metals shown significant antimicrobial activity based on the synthesis process, size, concentrations, and application. ,, Doped-IONPs were synthesized by using CP, CPA, MAP, GC, SGP, HDA, and solvothermal approach. However, the CP method was the most approached one due to its less complexity. ,,,, Moreover, the core advantage of the CP method over other synthesis methods is generating a large scale of nanoparticles.…”

Section: Doped-iron Oxide Nanoparticles (Doped-ionps)mentioning

confidence: 99%

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The Promise of Metal-Doped Iron Oxide Nanoparticles as Antimicrobial Agent

Tasnim,

Ferdous,

Rumon

et al. 2023

ACS Omega

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Antibiotic resistance (AMR) is one of the pressing global public health concerns and projections indicate a potential 10 million fatalities by the year 2050. The decreasing effectiveness of commercially available antibiotics due to the drug resistance phenomenon has spurred research efforts to develop potent and safe antimicrobial agents. Iron oxide nanoparticles (IONPs), especially when doped with metals, have emerged as a promising avenue for combating microbial infections. Like IONPs, the antimicrobial activities of doped-IONPs are also linked to their surface charge, size, and shape. Doping metals on nanoparticles can alter the size and magnetic properties by reducing the energy band gap and combining electronic charges with spins. Furthermore, smaller metal-doped nanoparticles tend to exhibit enhanced antimicrobial activity due to their higher surface-to-volume ratio, facilitating greater interaction with bacterial cells. Moreover, metal doping can also lead to increased charge density in magnetic nanoparticles and thereby elevate reactive oxygen species (ROS) generation. These ROS play a vital role to disrupt bacterial cell membrane, proteins, or nucleic acids. In this review, we compared the antimicrobial activities of different doped-IONPs, elucidated their mechanism(s), and put forth opinions for improved biocompatibility.

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