Assessment of Anterior Chamber by Ultrasound Biomicroscopy and Anterior Segment Optical Coherence Tomography in Patients with Inflammatory Glaucoma

Abstract

Objective To investigate the clinical indications of ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT) in eyes with inflammatory glaucoma. Methods Sixteen patients (16 eyes) with inflammatory glaucoma were analysed retrospectively. All of the subjects underwent UBM and AS-OCT scans, measuring the following parameters: central corneal thickness (CCT), central anterior chamber depth (ACD), angle-opening distance (AOD500), and trabecular-iris angle (TIA500) in four quadrants. Results Both the UBM and AS-OCT generated detailed, high-resolution images of the anterior segments of the eyes with inflammatory glaucoma. Moreover, the UBM and AS-OCT exhibited statistically similar measurement results for all of the indices. A Bland–Altman analysis showed a high level of agreement between the two imaging techniques. Additionally, the UBM was able to visualize the ciliary body and pars plana, while the cells and the flare in the anterior chamber appeared more pronounced in the UBM images. Conclusions Both the UBM and AS-OCT are useful tools for anterior segment imaging and taking measurements needed for evaluating inflammatory glaucoma. The AS-OCT has the advantages of being noninvasive and fast, whereas the UBM is presently unparalleled in the visualization of the ciliary body and pars plana.

Anterior Chamber Angle Assessment Techniques: A Review

“…In pigment dispersion syndrome, UBM has been used to show iris concavity and the changes of anterior lens surface during accommodation [43]. UBM also allows a better visualization of flare and cells into the anterior chamber, defining the severity and the extension of intraocular inflammation associated with glaucoma [44]. Moreover, Wang et al used UBM for ciliary body measurements, in eyes developing malignant glaucoma after trabeculectomy, and discovered that patients had on average thinner and anteriorly rotated ciliary body in both eyes, a potential predisposing factor to the disease [45].…”

In vivo analysis of ciliary muscle in myopic Chinese young adults using ArcScan Insight® 100

“…Additionally, the position of the iris makes imaging of the CM difficult 8 . Although AS‐OCT is a simple, noncontact alternative for imaging the anterior chamber angle, opaque tissues such as the pigmented posterior layer of the iris or sclera may prevent light transmission and thus limit the visualisation of the iris and CM 9,10 …”

“…8 Although AS-OCT is a simple, noncontact alternative for imaging the anterior chamber angle, opaque tissues such as the pigmented posterior layer of the iris or sclera may prevent light transmission and thus limit the visualisation of the iris and CM. 9,10 ArcScan Insight ® 100 (ArcScan, arcscan.com) is a precision ultrasound device for imaging and obtaining biometric measurements of the eye. It uses a 20-60 MHz transducer that scans the eye in an arc, the curvature of which approximates the anterior ocular surfaces.…”

A novel approach for forensic identification of automotive paints using optical coherence tomography and multivariate statistical methods

“…Here, we propose an emerging technique called optical coherence tomography (OCT), which allows for a nondestructive, high resolution, high speed and cross‐sectional imaging. Currently, OCT has been widely used in medicine, materials science, biology and other fields [21–24], but very few in forensic science. In recent years, researchers at home and abroad have gradually begun to explore the potential of OCT technology in forensic science.…”