Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behavior

Cardoso, Sérgio Vitorino; Souza, Kelen Christine N.; Faria, Paulo Rogério de; Eisenberg, A.; Dias, Fernando Luiz; Loyola, Adriano Mota

doi:10.1186/1471-2407-9-391

Cited by 31 publications

(40 citation statements)

References 23 publications

(29 reference statements)

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“…In the study conducted by Cardoso and others, which was similar to our study, it was detected that there is a higher increase in development of blood vessels within the malignant tumors compared to benign tumors (Cardoso et al, 2009).…”

Section: Discussionsupporting

confidence: 90%

“…In the same study conducted by Costa and Cardoso, it was evidenced that there is an increased incidence of blood vessel in MEC compared to ACC (Costa et al, 2008;Cardoso et al, 2009).…”

Section: Discussionmentioning

confidence: 72%

“…Intratumoral microvessel density (IMD) was quantified according to a recent consensus statement (Cardoso et al, 2009). Briefly, in an optical microscope hot-spot areas for CD105 expression in discrete blood vessles were in itially identified by scaning the entire tumor of low power (X40).…”

Section: Methodsmentioning

confidence: 99%

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Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To investigate the association between CD105 and tumor cell proliferation in salivary gland tumors. Methods: In this study, 59 samples of salivary tumors from Khalili Hospital archive, including 20 cases of pleomorphic adenoma (PA), 20 cases of mucoepidermoid carcinoma (MEC) and 19 cases of adenoid cystic carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by immunohistochemistry (IHC) for CD105 and Ki67 staining. Results: CD105 positive vessels were absent in normal salivary gland tissue in the vicinity of tumors (51.6% of all tumors were positive). There was a statistically significant difference in frequency of CD105 staining between PA and malignant tumors and between four groups of different lesions (p<0.000) being highest in MEC. Intratumoral microvessel density was also elevated in malignant neoplasms (2.61±3.1) as compared to PA (0.46±0.6). Normal salivary glands did not express Ki67. There was a statistically significant difference in frequency and percentage of Ki67 immunoreactivity in malignant neoplasms (86.5% and 10.7±10.8 respectively) compared to PA (50% and 0.78±0.2) and among the four groups values were highest in MEC (p<0.000). Conclusion: n this study, it was observed a higher rate of angiogenesis and cellular proliferation was noted in malignant tumors compared to benign tumors, but no correlation was observed between these two markers.

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Section: Discussionsupporting

confidence: 90%

“…In the same study conducted by Costa and Cardoso, it was evidenced that there is an increased incidence of blood vessel in MEC compared to ACC (Costa et al, 2008;Cardoso et al, 2009).…”

Section: Discussionmentioning

confidence: 72%

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Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Andisheh-Tadbir¹,

Pardis²,

Ashkavandi³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…These findings are in line with previous observations of (Cardoso et al, 2009 andMoghadam et al, 2015) who reported that salivary gland carcinomas demonstrated higher increase in the formation of blood vessels than benign tumors. Thus, the present and the previous findings prove that the development of new blood vessels is essential for clonal expansion which reflects higher rate of neovascularization and invasiveness of malignant SGTs (Sharma et al, 2005).…”

Section: Results:-supporting

confidence: 93%

“…Discussion:-Malignant SGTs constitute a major challenge in head and neck oncology because of its low frequency, variation in histological types, difficult surgical approach and poor response to therapy. Therefore, the present study was conducted to evaluate the quantification of angiogenesis in SGTs by measuring the MVD, since it is considered as an important prognostic factor which significantly associates with overall survival and correlates with the grades of malignancy (Cardoso et al, 2009). …”

Section: Results:-mentioning

confidence: 99%

Expression of Cd105 and Cd31 in Benign and Malignant Salivary Gland Tumors With Myoepithelial Differentiation (A Comparative Study).

Hassabou¹,

Kasem²,

Farag³

et al. 2017

IJAR

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Background and Aim:One of the strongest prognostic factors in tumor grading is tumor neovasculature. Hence, angiogenesis is an important target to eliminate tumor growth and metastasis. This study was carried out with the aim of evaluating the angiogenesis in salivary gland tumors by assessing microvessel density (MVD) using CD105 and CD31. This work also compared and correlated the expressions of both markers in benign and malignant salivary gland tumors (SGTs) and in grades of malignant tumors with myoepithelial differentiation. Material and Methods: The material of this work consisted of 76 paraffin embedded specimens including 20 benign tumors and 48 malignant tumors with different grades and types and 8 non neoplastic salivary gland tissues. Immunohistochemical staining was performed using both primary mouse monoclonal CD31 and CD105 antibodies for assessment of angiogenesis. Results: All studied cases showed positive CD31 and CD105 immunoreactivity. The study revealed a highly significant increase of CD31-MVD and CD105-MVD in malignant SGTs compared to benign tumors. Also, high grade malignancy demonstrated an increase in MVD when compared to low grade malignancy. In addition, malignant SGTs without myoepithelial cell differentiation showed significantly higher values of CD31-MVD and non significant difference of CD105-MVD compared to those containing myoepithelial cells. CD31-MVD values were always higher than CD105 in all studied cases. Conclusion: CD105 was more accurate in the assessment of tumor angiogenesis compared to the most commonly used CD31 panendothelial marker.

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Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands

Souza

Oliveira

Nonaka

et al. 2017

Eur Arch Otorhinolaryngol

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This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Higher GLUT-1 immunoexpression was observed in the MECs compared to PAs and ACCs (p = 0.022). Mean number of microvessels was 66.5 in MECs, 40.4 in PAs, and 21.2 in ACCs (p < 0.001). GLUT-1 expression and angiogenic index showed no significant correlation in the tumors studied. Results suggest that differences in biological behavior of the studied tumors are related to GLUT-1. Benign and malignant salivary gland tumors differ in the angiogenic index; however, angiogenesis may be independent of the tumor cell's metabolic demand.

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Assessment of angiogenesis by CD105 antigen in epithelial salivary gland neoplasms with diverse metastatic behavior

Cited by 31 publications

References 23 publications

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Expression of Ki67 and CD105 as Proliferation and Angiogenesis Markers in Salivary Gland Tumors

Expression of Cd105 and Cd31 in Benign and Malignant Salivary Gland Tumors With Myoepithelial Differentiation (A Comparative Study).

Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands

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