Assessment of anaerobic blood cultures in pediatric oncology patients

Cabedo, Manuel Monsonís; Rives, Susana; Noguera-Julián, Antoni; Ayala, Mireia Urrea; Cruz, Ofelia; Giralt, Amadeu Gené

doi:10.1016/j.eimc.2016.04.009

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…This low number supports previous findings that anaerobic bacteremia is extremely rare in children (2,18,23). Specifically, in a study from Spain on immunocompromised children under 18 years, only 3/90 bacterial organisms recovered were obligate anaerobes, and all were considered contaminants (19) study in a pediatric ED reported recovery of 595 bacterial organisms out of 2,675 paired blood cultures (11.1%; 595/5,350) over a 24-month period (18). In immunocompetent patients, almost all significant organisms were recovered from aerobic blood cultures.…”

Section: Discussionsupporting

confidence: 88%

“…Implementation of a blood culture set in the ED that includes the collection of both aerobic and anaerobic blood cultures was initiated on 1 February 2017, thus affording us the ability to study the effects of routinely collecting both cultures. Our positivity rate of 7.1% (635/8,978) in the postimplementation phase was slightly lower than the preimplementation rate (8.8%) as well as past studies that report positivity rates between 10.2 and 11.1% (18,19). This slight change may be attributed to a number of variables, including unnecessary blood culture collection and blood volume.…”

Section: Discussioncontrasting

confidence: 61%

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The Addition of Anaerobic Blood Cultures for Pediatric Patients with Concerns for Bloodstream Infections: Prevalence and Time to Positive Cultures

et al. 2020

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Anaerobes are an important but uncommon cause of bloodstream infections (BSIs). For pediatric patients, routine inclusion of an anaerobic blood culture alongside the aerobic remains controversial. We implemented automatic anaerobic blood culture alongside aerobic blood cultures in a pediatric emergency department (ED) and sought to determine changes in recovery of obligate and facultative anaerobes. This was a cohort study in a pediatric ED (August 2015 to July 2018) that began in February 2017. Blood culture positivity results for true pathogens and contaminants were assessed, along with a secondary outcome of time-to-positivity (TTP) of blood culture. A total of 14,180 blood cultures (5202-pre and 8978-post) were collected, with 8.8% (456) and 7.1% (635) positive cultures in the pre and post-implementation phases, respectively. Of 635 positive cultures in the post-implementation phase, aerobic blood cultures recovered 7.6% (349/4615), whereas anaerobic blood cultures recovered 6.6% (286/4363). In 211/421 (50.0%) paired blood cultures, an organism was recovered in both cultures. The number of cases where organisms were only recovered from an aerobic or an anaerobic bottle in the paired cultures were 126 (30.0%) and 84 (20.0%), respectively. The TTP was comparable regardless of bottle type. Recovery of true pathogens from blood cultures was approximately 7 hours faster than recovery of contaminants. Although inclusion of anaerobic blood cultures only recovered 2 (0.69%) obligate anaerobes it did allow for recovery of clinically significant pathogens that were negative in aerobic blood cultures and supports the routine collection of both bottles in pediatric patients with concern for bloodstream infections.

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Section: Discussionsupporting

confidence: 88%

Section: Discussioncontrasting

confidence: 61%

The Addition of Anaerobic Blood Cultures for Pediatric Patients with Concerns for Bloodstream Infections: Prevalence and Time to Positive Cultures

et al. 2020

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“…All blood cultures were processed with the BacT/Alert (bioMerieux; Marcy l'Etoile, France) automatic incubation system, and confirmed using standardized microbiological techniques. Given that anaerobic blood culture bottles offer no additional advantages over aerobic media, each blood specimen was collected into a pediatric aerobic bottle. A minimum of 1 mL blood volume was accepted.…”

Section: Methodsmentioning

confidence: 99%

Central line‐associated bloodstream infection in childhood malignancy: Single‐center experience

Miliaraki

Katzilakis

Chranioti

et al. 2017

Pediatrics International

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“…Клинически значимая бактериемия может возникать при распаде опухолей, вследствие повышения проницаемости слизистых оболочек и снижения иммунитета, особенно в случаях химиотерапии и лучевой терапии c нейтропенией; при инвазивных и эндоскопических медицинских процедурах, которые часто проводят при опухолевых заболеваниях [23,47,53]. При онкологических заболеваниях в зависимости от «входных ворот» инфекции и клинической ситуации наблюдается бактериемия как с типичными для ИЭ возбудителями (S. mitis, S. galolyticus, другие стрептококки группы D, энтерококки, Staphylococcus aureus), так и с редкими для ИЭ микроорганизмами, как, например, Lomentospora prolificans [15,28,43,48,[54][55][56][57][58][59][60]. Лучшая модель, иллюстрирующая эту гипотезу, как уже было отмечено выше, -ИЭ, вызванный S. gallolytocus, у больных с опухолями кишечника.…”

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Infective Endocarditis and Malignant Neoplasms: Facts and Hypotheses

Чипигина¹,

Карпова²,

Барсегян³

et al. 2018

Klinicist

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The problem of the association of infective endocarditis (IE) and oncological diseases has been discussed for more than 60 years, and is now becoming increasingly relevant because of observed increasing of number IE in elderly patients. The review of the literature presents both data on the incidence of oncological diseases diagnosed with IE and in the long-term follow-up of patients after IE, as well as current estimates of IE incidence in cancer patients, obtained in large population-based studies. The highest risk of IE development was found in patients with tumors of the colon and rectum, and the predominant etiological role of Streptococcus bovis/gallolyticus was proved in such cases. The frequency of concomitant oncological diseases is higher in elderly patients with IE. On the other hand, it is obvious that IE can be considered as a marker of latent oncological pathology, especially gastrointestinal tumors, malignant blood diseases and lymphoproliferative diseases that are most often detected during the period of active IE and in the first 1–2 years later. Therefore, mandatory colonoscopy is recommended for patients with IE caused by Streptococcus bovis/gallolyticus during the period of IE and annually in subsequent years, even if initially the colonoscopy did not reveal pathology. In elderly IE patients we should also be aware of the high likelihood of concomitant oncological pathology and carry out appropriate oncological search. Antimicrobial prophylaxis of IE in patients with gastrointestinal cancer remains unresolved.

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Assessment of anaerobic blood cultures in pediatric oncology patients

Cited by 6 publications

References 13 publications

The Addition of Anaerobic Blood Cultures for Pediatric Patients with Concerns for Bloodstream Infections: Prevalence and Time to Positive Cultures

The Addition of Anaerobic Blood Cultures for Pediatric Patients with Concerns for Bloodstream Infections: Prevalence and Time to Positive Cultures

Central line‐associated bloodstream infection in childhood malignancy: Single‐center experience

Infective Endocarditis and Malignant Neoplasms: Facts and Hypotheses

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