Assessment of adrenocortical activity in term newborn infants using salivary cortisol determinations

Francis, SE; Walker, Richard F.; Riad-Fahmy, D; Hughes, D; Murphy, J F; Gray, O.P.

doi:10.1016/s0022-3476(87)80359-1

Cited by 77 publications

(65 citation statements)

References 15 publications

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“…4,5 There is no doubt that at 45 days of life the circadian rhythm is present, however, it attains complete maturity, guaranteeing a similar response to adult behavior, from 1 year onwards, as observations of this sample have shown.…”

Section: Resultssupporting

confidence: 51%

“…Faced with the immaturity of children, there are doubts about the age at which circadian rhythms begin; the most up-to-date literature puts the start of this synchronization at 8 to 12 weeks. 4,14,15 Other authors state that children may present differences in cortisol levels at different times of day, but that this difference will only attain an amplitude similar to that of adults when the rhythms have matured. Zurbrügg 27 suggested that circadian maturity is possible from 2 years on.…”

Section: Resultsmentioning

confidence: 99%

“…It is an alternative test and is more sensitive than plasma and urine-based techniques, in addition to offering repeated collections with no stress or blood letting. 1,[3][4][5][6][7][8][9][10][11] There is work in the literature that demonstrates the applicability of salivary cortisol assay to the study of circadian rhythms, [12][13][14][15] to cognitive function disorders and to the influence of stress on the axis, triggered by anxiety, depression, panic syndrome and sleep deprivation. 1 The most recent application for the method is for the diagnosis of Cushing's syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Cortisol salivar na avaliação do eixo hipotálamo-hipofisário-adrenal em crianças saudáveis menores de 3 anos

Silva¹,

Mallozi²,

Ferrari³

2007

J. Pediatr. (Rio J.)

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Objective: To establish reference concentration intervals for salivary cortisol in healthy children, in the morning and in the afternoon, investigating factors that interfere with the concentration measured and the possibility that circadian rhythms are present.Methods: A controlled observational study was carried out with 91 children aged 45 days to 36 months, selected at random and living in Santo André, state of São Paulo, Brazil. Inclusion criteria were: healthy, well-nourished, free from fever and corticoid use, subdivided by age group (five subsets) at 6-month intervals. Saliva was collected during home visits in the morning and afternoon. Cortisol was radioimmunoassayed with cortisol 3-oxime-bovine albumin antiserum. Results:The five subsets exhibited higher cortisol concentration during the morning than in the afternoon (p < 0.001), and this difference passed 30% from 1 year of age onwards. Mean concentrations, in nmol/L, were 557.86 (morning) and 346.36 (afternoon). A negative linear correlation was observed between morning concentrations and hours' sleep and frequency of meals (p < 0.05), and in the afternoon with anthropometric measurements (p < 0.05). Conclusions:Reference values for normal salivary cortisol in healthy children were established. At 45 days it was possible to observe circadian rhythms, which reached maturity at 12 months of life. Sleep and food deprivation increased morning cortisol levels.J Pediatr (Rio J). 2007;83(2):121-126: Saliva, circadian rhythm, pituitary-adrenal axis, suppression.

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Section: Resultssupporting

confidence: 51%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cortisol salivar na avaliação do eixo hipotálamo-hipofisário-adrenal em crianças saudáveis menores de 3 anos

Silva¹,

Mallozi²,

Ferrari³

2007

J. Pediatr. (Rio J.)

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“…However, it has been described that free hormone fraction level tends to be similar to that observed among adults, apparently secondary to a low serum cortisol-binding globulin (CBG) concentration. 4,5 Cortisol in saliva is a reliable marker of the hypothalamicpituitary-adrenal axis activity; it correlates with plasma cortisol and reflects plasma free cortisol levels. 6 Saliva specimens are relatively easy to collect with a non-invasive technique 6,7 and they can be successfully collected in newborn infants by using different stimulating agents like citric acid 4,7,8 or lemon juice.…”

Section: Introductionmentioning

confidence: 99%

Salivary and serum cortisol levels in newborn infants

et al. 2017

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Introduction.Given that serum cortisol level interpretation in newborn infants (NBIs) is hard, the objective of this study was to correlate baseline salivary and serum cortisol levels and to describe salivary cortisol levels in the first month of life. Population and Methods. Descriptive, prospective, longitudinal, and correlational study. Term NBIs were selected from the Division of Neonatology of Hospital Nacional Profesor Alejandro Posadas in 2014. Cortisol was measured in saliva specimens while cortisol, cortisol-binding globulin, and albumin were measured in blood specimens. A linear correlation was performed to relate serum and salivary cortisol levels; Friedman test was conducted to compare cortisol levels during the first month of life, and the difference was used to analyze the performance of values equal to or lower than the first quartile. Results. Fifty-five NBIs were studied. Serum cortisol: 7.65 (1.0-18.1 µg/dL); salivary cortisol: 35.88 (5.52-107.64 mmol/L); cortisol-binding globulin: 22.07 (16.5-33.0 µg/mL), expressed as median and range. The correlation coefficient between serum and salivary cortisol was 0.54, P = 0.001. Cortisol performance during the first month of life showed no statistically significant differences, and the difference between the second and the first specimen of values equal to or lower than the first quartile increased in 10 out of 12 patients. Conclusion. The measurement of cortisol in saliva reflects serum cortisol levels in normal NBIs. Some patients had low levels of cortisol at 36 hours of life and showed a trend towards a spontaneous increase during the first month of life.

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“…非人灵长类观赏旅游，不仅能够提高公众的自然保护意识 (Newsome et al, 2005;Fennell, 2008)，获得稳定的资金以促进保护区和国家公园的基础设施建设及物种保护，同时也可以提供给当地居民更多的就业机会，最终促进社区经济发展 (Horwich, 1990;Brandon, 1996;Horwich, 1998;Zinner et al, 1998;Xiang et al, 2011)。然而，与游客的长期接触将不可避免地给动物带来一些负面影响。一般来说，对动物行为格局 (Zhao, 1991;Treves & Brandon, 2005;Hsu et al, 2009;Maréchal et al, 2011)、生理状态 (Behie et al, 2010;Maréchal et al, 2011)以及人兽共患疾病传播 (Wallis & Lee 1999;Vié 1999;Lafferty et al, 2002)等方面的干扰将影响种群健康和繁殖以及种群结构和数量等 (Jiang et al，1994;Takahata et al, 1998;Torre et al, 2000;Berman et al, 2007) (Francis et al, 1987;Sapolsky, 1993;Elder, 2001;Cross et al, 2004;Maréchal et al, 2011)，其粪便皮质醇浓度已被广泛应用于个体急、慢性压力研究 (Sapolsky, 1993;Crockett, 2000;Cross et al, 2004;Barbosa & Mota, 2009;Maréchal et al, 2011) …”

unclassified

Ecotourism disturbances to non-human primates

Fan¹,

Xiang²

2013

Zoological Research

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Assessment of adrenocortical activity in term newborn infants using salivary cortisol determinations

Cited by 77 publications

References 15 publications

Cortisol salivar na avaliação do eixo hipotálamo-hipofisário-adrenal em crianças saudáveis menores de 3 anos

Cortisol salivar na avaliação do eixo hipotálamo-hipofisário-adrenal em crianças saudáveis menores de 3 anos

Salivary and serum cortisol levels in newborn infants

Ecotourism disturbances to non-human primates

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