Assessment of adiponectin level in obese and lean Nepalese population and its possible correlation with lipid profile: A cross-sectional study

Abstract

Objective:Adiponectin- one of the most important adipokines plays a pivotal role in carbohydrate and lipid metabolism and vascular biology. Changing food trend and lifestyle has tremendously affected the health status of Nepalese population. Studies have shown that between 1996 and 2006 obesity in Nepal has increased from 1.6% to 10%. Studies have been conducted in Nepal on the prevalence of obesity and its correlation with lipid profile. But based on our knowledge, this is the first study correlating adiponectin with obesity and lipid profile in Nepal. This piece of work will certainly help to assess the impact of obesity in Nepalese population.Materials and Methods:Fifty four obese and Thirty six normal/lean participants were included from different locations of Kathmandu Valley. Anthropometric measurements like age, BMI, Waist circumference, hip circumference, waist to hip ratio, mid thigh circumference and chest circumferences were taken from each participant. Blood glucose, lipid profile and serum adiponectin levels were measured from overnight fasting samples.Results:Significant differences were observed in BMI, Waist Circumference, Hip Circumference, Waist to Hip Ratio (WHR) and Chest circumference between obese and normal groups. Fasting Blood Glucose, Serum Triglyceride, HDL Cholesterol, LDL Cholesterol, Total Cholesterol/HDL ratio, Non-HDL Cholesterol and Adiponectin Levels were significant between the groups. Inverse correlations were observed between adiponectin level and BMI, Waist Circumference, Hip Circumference, Waist to Hip ratio, Chest Circumference, Fasting Blood Glucose, Triglyceride, Total Cholesterol/HDL ratio, LDL/HDL Cholesterol ratio and Non-HDL Cholesterol levels. Positive correlation was found between adiponectin and HDL Cholesterol levels.Conclusion:Our study showed significant inverse association of serum adiponectin with obesity and lipid profile parameters except for Serum HDL Cholesterol level in Nepalese population.

25-Hydroxy Vitamin D, Adiponectin Levels and Cardiometabolic Risk Factors in a Sample of Obese Children

“…In agreement with these findings, Tamang et al, [29] reported that serum adiponectin correlates positively with HDL-C levels in obese subjects. They suggested that the possible mechanisms may partially be explained with the activated receptor, which affects the genes, associated with HDL metabolism.…”

Decreased Serum HDL at Initial Diagnosis Correlates with Worse Outcomes for Triple-Negative Breast Cancer but Not Non-TNBCs

“…Another possible mechanism is that HDL cholesterol correlates negatively with ANG II, but ANG II is positively associated with VEGF in TNBC, while the VEGF signaling pathway plays a pivotal role in TNBC (2, 32, 33); therefore, low HDL may lead to more aggressive behavior of TNBC. Besides that, a positive correlation was found between adiponectin and HDL (34, 35), and in a Korean cohort study, serum adiponectin concentrations showed a significant inverse association with ER/PR-negative BC recurrence (p = 0.009) (9). These are just assumptions regarding the underlying mechanisms for the influence of HDL on TNBCs, however, and this is still far from explaining why low HDL acts differently between TNBC and non-TNBC patients.…”

Evaluation of proinflammatory cytokines in obese vs non-obese patients with metabolic syndrome

“…[46] In agreement with our study, no correlation was found between parameters of fatness and adiponectin level. [46] An inverse correlation was also found between adiponectin, TC and TG by Tamang et al [47] Another study revealed a significant negative correlation between adiponectin and weight, BMI, fat mass, adverse lipid levels like TC and TG and a positive correlation with serum HDL levels. [9] The study consisted of a small sample size of patients with more pronounced obesity.…”