Assessment of Acute Toxicity of Cobalt Tetrasulfophthalocyaninate by Intravenous Injection on Wistar Rats

Криштоп, В. В.; Демидов, В. И.; Томилова, И К; Nikonorova, V.G.; Tarasuk, I. A.; Botnar, A. A.; Вашурин, А. С.; Marfin, Yuriy S.

doi:10.6060/mhc191179k

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“…Many studies have presented the use of specific carriers modifying the properties of porphyrinoids and allowing their application in stable suspensions in water. This method simultaneously increases their application in targeted therapy whilst reducing their intrinsic toxicity [ 13 , 14 , 15 ]. The delivery agents tested to the greatest extent are liposomes [ 16 , 17 ], metal and metal oxide nanoparticles [ 18 , 19 , 20 ], and polymeric nanomaterials [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Nipagin-Functionalized Porphyrazine and Phthalocyanine—Synthesis, Physicochemical Characterization and Toxicity Study after Deposition on Titanium Dioxide Nanoparticles P25

et al. 2021

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Aza-porphyrinoids exhibit distinct spectral properties in UV-Vis, and they are studied in applications such as photosensitizers in medicine and catalysts in technology. The use of appropriate peripheral substituents allows the modulation of their physicochemical properties. Phthalocyanine and sulfanyl porphyrazine octa-substituted with 4-(butoxycarbonyl)phenyloxy moieties were synthesized and characterized using UV-Vis and NMR spectroscopy, as well as mass spectrometry. A comparison of porphyrazine with phthalocyanine aza-porphyrinoids revealed that phthalocyanine macrocycle exhibits higher singlet oxygen generation quantum yields, reaching the value of 0.29 in DMF. After both macrocycles had been deposited on titanium dioxide nanoparticles P25, the cytotoxicities and photocytotoxicities of the prepared materials were studied using a Microtox® acute toxicity test. The highest cytotoxicity occurred after irradiation with a red light for the material composed of phthalocyanine deposited on titania nanoparticles.

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