Assessment of absolute Tc-99m tetrofosmin retention in the myocardium as an index of myocardial blood flow and coronary flow reserve by gated-SPECT/CT: a feasibility study

Abstract

Despite the low myocardial extraction fraction of Tc-99m tetrofosmin, an approximation of MBF and CFR is feasible with gated-SPECT/CT MPI. These flow indices together were able to discriminate CAD patients from controls and stratify different patient subgroups.

Visit to intensive care of 2050

“…For example, since heart disease remains a major determinant of life expectancy, most general ICUs have integrated cardiology services. Patients presenting with an acute cardiac event are evaluated by utilizing bedside computerized tomography, which provides not only structural but also physiological/ functional data [23,24]. These data are exported into a nanotechnology interventional system that performs cardiac procedures when required (e.g.…”

Diagnostic Utility of Quantifying Myocardial Flow Reserve with ^99mTc-Sestamibi Dynamic SPECT Using a Standard Dual-Head SPECT Camera

“…We did not examine normal healthy subject in this study, thus we could not confirm relevance of these risk factors and the MFR reduction. Earlier study showed the significant difference between the MFR of diabetic CAD patients and that of non-diabetics using a hybrid SPECT/CT camera (23). Moreover, they showed the association between age, sex, smoking habit, and reduced MBF.…”

Recent advances in cardiac SPECT instrumentation and imaging methods

“…In Apostolopoulos et al (2015), the MBF index was calculated for both rest and stress by combining 2-dimensional (2D) planar data with 3D SPECT. Immediately after tracer injection, the first-pass 2D planar images were acquired in early phases with high temporal resolution to obtain the integral of blood pool activity as input function.…”