Assessment of a Point-of-Care Lactate Monitor in Emergency Admissions of Adult Horses to a Referral Hospital

Tennent-Brown, Brett S.; Wilkins, Pamela A.; Lindborg, S.; Russell, Gail E.; Boston, Raymond C.

doi:10.1892/0891-6640(2007)21[1090:aoaplm]2.0.co;2

Cited by 25 publications

(47 citation statements)

References 39 publications

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“…24,25 Urine creatinine concentration and GGT activity were measured (-24 and 24 hours) by use of an automated chemistry analyzer j with commercially available reagents and standards. Urine GGT (U/L)-to-creatinine (mmol/L) ratio was calculated.…”

Section: Administration Of Lps and Polymyxin B-mentioning

confidence: 99%

“…Although a significant increase in neutrophil counts in the study reported here was detected in the polymyxin B group at 8 hours, compared with the control foals, significantly lower neutrophil counts were reported at 24 and 48 hours. Considering the time (8,24, and 48 hours) at which these differences were detected, it is likely that the differences in neutrophil counts were associated with varying degrees of rebound neutrophilia commonly observed after a severe neutropenic episode. 15,39 Thus, it is unlikely that polymyxin B administration had any clinically beneficial effect on the WBC or neutrophil count in this study.…”

Section: 33mentioning

confidence: 99%

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Effects of intravenous administration of polymyxin B in neonatal foals with experimental endotoxemia

Wong¹,

Sponseller²,

Alcott³

et al. 2013

javma

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Objective—To evaluate the effect of IV administration of polymyxin B on clinical and serum biochemical variables in foals with experimental endotoxemia. Design—Prospective experimental study. Animals—14 healthy neonatal foals. Procedures—Foals were randomly assigned to a treatment or control group and were administered a single dose of lipopolysaccharide (0.5 μg/kg [0.23 μg/lb]) IV over 30 minutes. The treatment group received polymyxin B (6,000 U/kg [2,727 U/lb], IV) immediately after completion of lipopolysaccharide infusion; the control group was administered an equal volume of saline (0.9% NaCl) solution. Subsequent doses of polymyxin B or saline solution were administered IV at 8 and 16 hours. Blood was collected at various time points, and outcome variables, including heart rate, respiratory rate, rectal temperature, attitude score, WBC count, neutrophil count, lymphocyte count, monocyte count, platelet count, Hct, blood lactate concentration, blood glucose concentration, serum tumor necrosis factor-α concentration, and plasma thromboxane B2 concentration, were measured. Urine was collected prior to and after experimentation to determine whether nephrotoxicosis was associated with treatment. Results—The treatment group had significantly lower blood lactate concentration and serum tumor necrosis factor-α and plasma thromboxane B2 concentrations and had higher blood glucose concentrations and better attitude scores, compared with the control group, at various time points during the study. No other significant differences and no evidence of overt nephrotoxicosis were detected. Conclusions and Clinical Relevance—Administration of polymyxin B IV in healthy neonatal foals challenged with lipopolysaccharide attenuated some clinical and serum biochemical derangements associated with endotoxemia.

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Section: Administration Of Lps and Polymyxin B-mentioning

confidence: 99%

Section: 33mentioning

confidence: 99%

Effects of intravenous administration of polymyxin B in neonatal foals with experimental endotoxemia

Wong¹,

Sponseller²,

Alcott³

et al. 2013

javma

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“…It is particularly important to evaluate POC monitors in the population in which they will be used because underlying pathophysiology may introduce unexpected, and unmeasurable, bias. This problem was demonstrated in a recent study evaluating the performance of a POC lactate meter in which performance of the meter was different at PCV < 40% when compared with patients with PCV ≥ 40%, although PCV itself did not have significant impact on meter function when investigated singly 7 . Additionally, POC glucose monitors may perform differently at extremes of blood glucose concentration, such as reported in adult horses with acute abdominal disease, 6 than in the normal range.…”

mentioning

confidence: 99%

Comparison of the Accu‐Chek Aviva Point‐of‐Care Glucometer with Blood Gas and Laboratory Methods of Analysis of Glucose Measurement in Equine Emergency Patients

Hollis

Schaer

Boston

et al. 2008

Veterinary Internal Medicne

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Background: More information is needed regarding accuracy of commonly used methods of glucose measurement in the critically ill horse.Hypothesis: Glucometry will have good agreement with a laboratory standard. Glucometry with plasma will have better agreement than when performed with whole blood.Animals: Fifty sequentially admitted equine emergency patients, aged 41year. Methods: Venous blood was collected at admission and immediately analyzed by point-of-care glucometry on both whole blood (POC/WB) and plasma (POC/PL), a multielectrode blood gas analyzer with whole blood (BLG), and a standard laboratory method with plasma (CHEM). Paired data were compared using Lin's concordance correlation, Pearson's correlation, and robust regression. Bias and limits of agreement were tested by the Bland-Altman technique. Bivariate regression analysis was used to explore confounding factors.Results: Concordance was significant for all comparisons, and was strongest for CHEM-POC/PL (0.977) and weakest for POC/WB-POC/PL (0.668). Pearson's correlation was excellent for all comparisons except those with POC/WB. All comparisons had excellent robust regression coefficients except those with POC/WB.Conclusions and Clinical Importance: POC glucometry with plasma had excellent agreement with a laboratory standard, as did blood gas analysis. POC glucometry with whole blood correlated poorly with a laboratory standard. These differences may be clinically important, and could affect decisions based on glucose concentrations.

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“…The lactate function has been validated for use in horses (Tennent-Brown and others 2007) while the triglyceride function has been validated for use in dogs and cats (Kluger and others 2010a, b). The device costs approximately £250 and each test around £2.40.…”

mentioning

confidence: 99%

Use of the Accutrend Plus point‐of‐care monitor for blood triglyceride measurement in horses

Naylor

Durward‐Akhurst

2012

Veterinary Record

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ELEVATED triglyceride concentrations are a common consequence of negative energy balance in equids (Naylor and others 1980). They are most often observed in overweight ponies, miniature horses and donkeys experiencing an increased energy demand, anorexia or subsequent to an underlying disease promoting the release of inflammatory mediators, which promote lipid catabolism. Clinical signs of equine dyslipidaemias are non specific, and can be masked by, or attributed to, any underlying disease process if present (Mogg and Palmer 1995); therefore, clinically significant increases in triglyceride concentrations may go undetected. Rapid diagnosis of elevated triglyceride concentration is important to allow prompt initiation of therapy, which is important for a successful outcome (Burden and others 2011). The Accutrend Plus (Roche Diagnostics; AP) is a handheld monitor marketed for the measurement of blood cholesterol, glucose, lactate and triglyceride concentrations in human beings (Moses and others 1996, Luley and others 2000). The lactate function has been validated for use in horses (Tennent-Brown and others 2007) while the triglyceride function has been validated for use in dogs and cats (Kluger and others 2010a, b). The device costs approximately £250 and each test around £2.40. Currently, no point-of-care monitors are validated to measure blood triglyceride concentrations in horses. A point-of-care monitor with the facility to measure triglyceride concentrations would be useful in diagnosing dyslipidaemias and monitoring the response to treatment in situations where laboratory access is unavailable. The objective of this study was to evaluate the AP in comparison to a laboratory gold standard for the measurement of equine blood triglyceride concentration. During this prospective cohort study, any horse, pony or donkey admitted to the Royal Veterinary College Equine Referral Hospital between April and December 2010, where the serum triglyceride concentration was measured, was included in the study. A sample of 2 ml of venous blood was collected via direct venepuncture from the jugular vein, and transferred into lithium

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Assessment of a Point-of-Care Lactate Monitor in Emergency Admissions of Adult Horses to a Referral Hospital

Cited by 25 publications

References 39 publications

Effects of intravenous administration of polymyxin B in neonatal foals with experimental endotoxemia

Effects of intravenous administration of polymyxin B in neonatal foals with experimental endotoxemia

Comparison of the Accu‐Chek Aviva Point‐of‐Care Glucometer with Blood Gas and Laboratory Methods of Analysis of Glucose Measurement in Equine Emergency Patients

Use of the Accutrend Plus point‐of‐care monitor for blood triglyceride measurement in horses

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