Assessing the Prevalence of Latent Tuberculosis among Health Care Providers in Zagazig City, Egypt Using Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Test

El-Sokkary, Rehab H.; Abutaleb, Ashwak M. F.; Seifi, Omnia S. El; Zidan, Haidy E.; Mortada, Eman M.; El-Hossary, Dalia; Farag, Salama E.

doi:10.21101/cejph.a4101

Cited by 15 publications

(12 citation statements)

References 30 publications

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“…In the subgroup analysis by study location, the pooled effect was significantly higher in studies carried out in Africa and North America, compared with studies carried out in Asia and Europe. HCW was the main population in the Africa group ( 35 ), which was the only study and led a high odds ratio of this group. Population of group North America consisted of refugees ( 33 , 36 ), community residents ( 18 , 22 ), elderly or patients with other chronic diseases ( 40 ) and household contacts ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Yan

et al. 2022

Front. Med.

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BackgroundThe estimated global latent tuberculosis infection (LTBI) burden indicates a large reservoir of population at risk of developing active tuberculosis (TB). Previous studies suggested diabetes mellitus (DM) might associate with LTBI, though still controversial. We aimed to systematically assess the association between DM and LTBI.MethodsWe searched PubMed, Embase, Cochrane Library and Web of Science. Observational studies reporting the number of LTBI and non-LTBI individuals with and without DM were included. Random-effects or fixed-effects models were used to estimate the pooled effect by risk ratios (RRs) and odds ratios (ORs) and its 95% confidence interval (CI), using the original number of participants involved.Results20 studies involving 4,055,082 participants were included. The pooled effect showed a significant association between DM and LTBI (for cohort studies, RR = 1.62, 95% CI: 1.02–2.56; for cross-sectional studies, OR = 1.55, 95% CI: 1.30–1.84). The pooled OR was high in studies with healthcare workers (5.27, 95% CI: 1.52–8.20), refugees (2.88, 95% CI: 1.93–4.29), sample size of 1,000–5,000 (1.99, 95% CI: 1.49–2.66), and male participants accounted for less than 40% (2.28, 95% CI: 1.28–4.06). Prediabetes also associated with LTBI (OR = 1.36, 95% CI: 1.01–1.84).ConclusionThe risk of LTBI was found to be a 60% increase in DM patients, compared with non-DM patients. LTBI screening among DM patients could be of vital importance. More studies are needed to explore appropriate strategies for targeted LTBI screening among DM patients.

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Section: Discussionmentioning

confidence: 99%

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Yan

et al. 2022

Front. Med.

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“…The global prevalence of LTBI was estimated at 23.0% in 2014. The South-East Asia Region had the highest prevalence of 30.8% 19 . The current lifetime risk of progression from LTBI to active TB disease is 5–15% 20 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of latent tuberculosis among Korean healthcare workers using whole-blood interferon-γ release assay

Yeon

Seong

Hur

et al. 2018

Sci Rep

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Because healthcare workers (HCWs) are at high risk for tuberculosis (TB) infection, it is essential to research the prevalence of latent TB infection (LTBI) and to implement health interventions including early treatment of LTBI and TB infection control measures. The purpose of the study was to determine the prevalence and risk factors for LTBI using interferon-γ release assay (IGRA) among HCWs in South Korea. The cross-sectional study was carried in the National Health Insurance Service Ilsan Hospital, which is a 740-bed general hospital, South Korea. HCWs who participated in this survey were required to complete a questionnaire and IGRA was performed. Of the 1,655 HCWs, 271 results were positive and the prevalence of LTBI was 16% (95% CI; 15–18%). In the multivariate analysis, age (OR; 2.201, 95% CI; 1.911–2.536, P < 0.001), male sex (OR; 1.523, 95% CI; 1.133–2.046, P = 0.005), contact active TB patients (OR; 1.461, 95% CI; 1.061–2.010, P = 0.02) and diabetes (OR; 2.837, 95% CI; 1.001–8.044, P = 0.05) were significant risk factors for LTBI. LTBI among HCWs in Korea, although prevalent, might not exceed the background level of the general population. Because contact with active TB patients has been identified as a risk factor for LTBI, more effective TB infection control measures are essential in healthcare facilities and congregate settings.

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“…There is a demand for more specific detection of human and bovine TB, which are caused by Mycobacterium tuberculosis and Mycobacterium bovis, respectively, − infecting the lungs and other organs. The 2015 global TB report estimated that 3.6 million cases of human TB were missed by health systems, and inaccurate diagnosis was considered to be one of the main factors causing this omission. , Therefore, a more effective and accurate diagnostic test is important for control of TB infection and transmission worldwide. ,,, Tuberculin skin testing (TST) is a primary diagnostic tool for both human and bovine TB and is used in programs for eradication of the disease in cattle throughout the world. However, false positive results can be obtained if humans or animals are exposed to nonpathogenic environmental mycobacteria or vaccinated with BCG. − Therefore, a new, highly accurate diagnostic reagent containing specific TB antigens is required to overcome the low specificity of TST .…”

Section: Biomedical Applications Of Pha–protein Assembliesmentioning

confidence: 99%

“…128,130 Therefore, a more effective and accurate diagnostic test is important for control of TB infection and transmission worldwide. 114,115,131,132 Tuberculin skin testing (TST) is a primary diagnostic tool for both human and bovine TB and is used in programs for eradication of the disease in cattle throughout the world. However, false positive results can be obtained if humans or animals are exposed to nonpathogenic environmental mycobacteria or vaccinated with BCG.…”

Section: Diagnostic Applications Of Engineered Phamentioning

confidence: 99%

Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications

Parlane

Gupta

Reyes

et al. 2016

ACS Biomater. Sci. Eng.

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Polyhydroxyalkanoates (PHAs) are biological polyesters that can be naturally produced by a range of bacteria as water-insoluble inclusions composed of a PHA core coated with PHA synthesis, structural, and regulatory proteins. These naturally self-assembling shell–core particles have been recently conceived as biomaterials that can be bioengineered as biologically active beads for medical applications. Protein engineering of PHA-associated proteins enabled the production of PHA–protein assemblies exhibiting biologically active protein-based functions relevant for applications as vaccines or diagnostics. Here we provide an overview of the recent advances in bioengineering of PHA particles toward the display of biomedically relevant protein functions such as selected disease-specific antigens as diagnostic tools or for the design of particulate subunit vaccines against infectious diseases such as tuberculosis, meningitis, pneumonia, and hepatitis C.

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Assessing the Prevalence of Latent Tuberculosis among Health Care Providers in Zagazig City, Egypt Using Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Test

Cited by 15 publications

References 30 publications

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

The Association Between Diabetes Mellitus and the Risk of Latent Tuberculosis Infection: A Systematic Review and Meta-Analysis

Prevalence and risk factors of latent tuberculosis among Korean healthcare workers using whole-blood interferon-γ release assay

Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications

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