Assessing the potential association between Epstein-Barr virus and oral squamous cell carcinoma: a systematic review and meta- analysis

Sivakumar, Shivaranjhany; Gupta, Archana; Rosdy, Nik Mohd Mazuan Nik Mohd; Venkiteswaran, Annapurny; Raj, A. Thirumal; Awan, Kamran Habib

doi:10.21037/tcr.2020.01.09

Cited by 5 publications

(15 citation statements)

References 30 publications

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“…A dichotomous score of 0 or 1 was given for each parameter assessed, and a composite score was calculated. A score of 7 and above was considered good and adequate (Moher et al, 2009; Shamseer et al, 2015; Sivakumar et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Melatonin levels in periodontitis vs. the healthy state: A systematic review and meta‐analysis

Madapusi¹,

Varadarajan²,

Jagannathan

et al. 2020

Oral Diseases

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The aim was to provide a comprehensive qualitative and quantitative assessment of any potential differences in melatonin levels in periodontitis vs. the healthy state.The keyword combination "melatonin" AND "periodontitis" was searched in Web of Science, PubMed, and Scopus. Qualitative analysis and quantitative analysis were | Inclusion criteriaOriginal research in English language assessing the melatonin levels in saliva, plasma, gingival crevicular fluid, or gingival tissue samples of humans with and without periodontitis was included in the study. | Exclusion criteriaReviews, letters, conference abstracts, articles in a language other than English, articles based on animal models, and articles wherein sufficient details on the melatonin level in periodontitis could not be elucidated were excluded from the study. | Focus question"Do the melatonin levels vary between healthy individuals and patients with periodontitis?" | Search strategyThe keyword combination "melatonin" AND "periodontitis" was searched on June 22nd, 2020, in Web of Science, PubMed, and Scopus. The identified articles were manually cross-referenced for potential articles. The search results in the databases are presented as Supporting information. | Study selection and data extraction1. The identified articles were screened using their titles and abstracts for potential duplicates and relevance to the topic Radioimmunoassay Mean melatonin levels in plasma Controls: 14.33 ± 4.05 picograms/ml Cases: 9.46 ± 3.18 picograms/ml A significant lowering of melatonin was observed in the plasma of cases compared with controls (p < .001) Negative correlation between age and plasma melatonin in controls observed (r = −0.672, p < .001). No correlation was observed in cases. Mean melatonin levels in saliva Controls: 4.22 ± 0.87 picograms/ml Cases: 2.55 ± 0.99 picograms/ml A significant lowering of melatonin was observed in the saliva of cases compared with controls (p < .001) Mean salivary to plasma melatonin ratio Controls: 0.30 ± 0.06 Cases: 0.31 ± 0.07 No significant difference in cases and controls (p > .05) Plasma melatonin levels increase in patients with CPI scores of 3 and 4 CD4 + counts in plasma had a negative correlation with both plasma and salivary melatonin levels in cases (p

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Section: Methodsmentioning

confidence: 99%

Melatonin levels in periodontitis vs. the healthy state: A systematic review and meta‐analysis

Madapusi¹,

Varadarajan²,

Jagannathan

et al. 2020

Oral Diseases

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“…Of the 32 studies included , 20 were systematic reviews with meta-analysis [36][37][38]41,44,46,49,50,53,54,56,57,[59][60][61][62][63][64][65][66] and 12 without meta-analysis [35,39,40,42,43,45,47,48,51,52,55,58]. The 32 systematic reviews included 642 studies that met the eligibility criteria of this umbrella review, in particular, 248 case-control studies, 29 cohort studies, 20 cross-sectional studies, 10 non-randomized studies, 2 retrospective cross-sectional studies, 1 cross-sectional cohort study, 1 prospective study, and 331 articles where the study design had not been defined.…”

Section: Study Selectionmentioning

confidence: 99%

Oral Bacteria, Virus and Fungi in Saliva and Tissue Samples from Adult Subjects with Oral Squamous Cell Carcinoma: An Umbrella Review

Di Spirito,

Di Palo,

Folliero

et al. 2023

Cancers

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Oral squamous cell carcinoma (OSCC) is the most common oral cavity malignancy associated with multiple risk factors. In the last 14 years, oral dysbiosis has attracted the scientific community’s attention as a potential oncogenic factor, in parallel with the development of omics technologies that have revolutionized microbiological research. The present umbrella review aimed to investigate the oral microbiological content (bacilli, viruses, and fungi) of tissue and saliva samples from adult (>18 years) patients with OSCC. The secondary objective was to compare the oral microbiome of OSCC subjects with non-OSCC subjects. The study protocol was under the PRISMA statement and registered on PROSPERO (CRD42023448153). Data from 32 systematic reviews were extracted, qualitatively summarized, and analyzed using AMSTAR-2. An increase in oral bacteria of the phylum Fusobacteria, Proteobacteria, and Bacteroidetes and a decrease in Firmicutes and Actinobacteria were observed in OSCC patients. The increased bacterial genera were periodontopathogens. The most common viruses were EBV and HPV, especially the high-risk genotypes. Candida was the most studied oral fungus and was always increased in OSCC subjects. Further studies should investigate the possible carcinogenic mechanisms of oral microorganisms found increased in tissue samples and saliva from adult subjects with OSCC.

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“…Apart from both quantitative and qualitative assessments of the Epstein-Barr virus (EBV) association with OSCC, the meta-analysis by Sivakumar et al affirmed the association between EBV and OSCC [14].…”

Section: Relationship Between Epstein-barr Virus and Osccmentioning

confidence: 99%

The Holistic Review on Occurrence, Biology, Diagnosis, and Treatment of Oral Squamous Cell Carcinoma

Alsaeedi¹,

Aggarwal²

2022

Cureus

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A prevalent head and neck cancer type is oral squamous cell carcinoma (OSCC). It is widespread and associated with a high death rate of around 50% in some regions of the world. We discuss the likelihood of developing OSCC and the impact of age in this review. Prior to examining the vast array of diagnostic indicators, a brief explanation of the biology of the disease is addressed. Finally, the therapeutic strategies for OSCC are listed. The complete literature for this study was compiled by searching Google Scholar and PubMed using the terms "OSCC," "oral squamous cell carcinoma," "diagnosis of OSCC," "oral cancer," and "biomarkers and OSCC." The research finds that OSCC has several critical parameters with a lot of room for additional in-depth study.

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Assessing the potential association between Epstein-Barr virus and oral squamous cell carcinoma: a systematic review and meta- analysis

Cited by 5 publications

References 30 publications

Melatonin levels in periodontitis vs. the healthy state: A systematic review and meta‐analysis

Melatonin levels in periodontitis vs. the healthy state: A systematic review and meta‐analysis

Oral Bacteria, Virus and Fungi in Saliva and Tissue Samples from Adult Subjects with Oral Squamous Cell Carcinoma: An Umbrella Review

The Holistic Review on Occurrence, Biology, Diagnosis, and Treatment of Oral Squamous Cell Carcinoma

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